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Portal hypertension: from bedside to bench.
J Clin Gastroenterol. 2005 Apr; 39(4 Suppl 2):S125-30.JC

Abstract

The initial factor leading to portal hypertension is an increase in hepatic resistance. Later, an increase in portal blood flow contributes to maintain and exacerbate portal hypertension despite the development of portosystemic collaterals. The critical step in the development and acceptance of these concepts, which proved crucial for the management of patients with portal hypertension, was the development of animal models. These allowed the full characterization of the profound hemodynamic abnormalities in the systemic and splanchnic circulation associated with portal hypertension, and the elucidation of the molecular mechanisms implicated in these disturbances. This review traces how seminal clinical observations in the 1950s raised meaningful questions that were subsequently answered at the bench, leading to our current understanding of the pathophysiology of portal hypertension and of the pathogenesis of severe complications of cirrhosis, such as variceal bleeding or ascites.

Authors+Show Affiliations

Groszmann RJ
Veterans Administration Medical Center, West Haven, CT 06516, USA. roberto.groszmann@yale.edu
Abraldes JG
No affiliation info available

MeSH

AnimalsHemodynamicsHumansHypertension, PortalLiver CirculationLiver CirrhosisNitric OxidePortal SystemSplanchnic CirculationVascular Resistance

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

15758647

Citation

Groszmann, Roberto J., and Juan G. Abraldes. "Portal Hypertension: From Bedside to Bench." Journal of Clinical Gastroenterology, vol. 39, no. 4 Suppl 2, 2005, pp. S125-30.
Groszmann RJ, Abraldes JG. Portal hypertension: from bedside to bench. J Clin Gastroenterol. 2005;39(4 Suppl 2):S125-30.
Groszmann, R. J., & Abraldes, J. G. (2005). Portal hypertension: from bedside to bench. Journal of Clinical Gastroenterology, 39(4 Suppl 2), S125-30.
Groszmann RJ, Abraldes JG. Portal Hypertension: From Bedside to Bench. J Clin Gastroenterol. 2005;39(4 Suppl 2):S125-30. PubMed PMID: 15758647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Portal hypertension: from bedside to bench. AU - Groszmann,Roberto J, AU - Abraldes,Juan G, PY - 2005/3/11/pubmed PY - 2005/7/12/medline PY - 2005/3/11/entrez SP - S125 EP - 30 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 39 IS - 4 Suppl 2 N2 - The initial factor leading to portal hypertension is an increase in hepatic resistance. Later, an increase in portal blood flow contributes to maintain and exacerbate portal hypertension despite the development of portosystemic collaterals. The critical step in the development and acceptance of these concepts, which proved crucial for the management of patients with portal hypertension, was the development of animal models. These allowed the full characterization of the profound hemodynamic abnormalities in the systemic and splanchnic circulation associated with portal hypertension, and the elucidation of the molecular mechanisms implicated in these disturbances. This review traces how seminal clinical observations in the 1950s raised meaningful questions that were subsequently answered at the bench, leading to our current understanding of the pathophysiology of portal hypertension and of the pathogenesis of severe complications of cirrhosis, such as variceal bleeding or ascites. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/15758647/Portal_hypertension:_from_bedside_to_bench_ DB - PRIME DP - Unbound Medicine ER -