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Characterization of localized seminal vesicle amyloidosis causing hemospermia: an analysis using immunohistochemistry and magnetic resonance imaging.
J Urol. 2005 Apr; 173(4):1273-7.JU

Abstract

PURPOSE

We evaluated the characteristics of seminal vesicle amyloidosis (SVA) associated with hemospermia by immunohistochemistry and magnetic resonance imaging (MRI) as well as the clinical course of hemospermia.

MATERIALS AND METHODS

Of 56 patients with hemospermia 12 underwent transperineal biopsy of the seminal vesicle under transrectal ultrasound monitoring. SVA was proved in 4 men 48 to 59 years old by histological and immunohistochemical examinations of specimens obtained by biopsy. Two men presented with the first episode of hemospermia and 2 presented with recurrent hemospermia. MRI at 1.5 Tesla was performed while hemospermia persisted and after its resolution. Patients were followed for 10 to 86 months with regard to the duration of hemospermia, the time of its resolution and its recurrence.

RESULTS

Amyloid deposits in the subepithelial tissue of the seminal vesicles were permanganate sensitive, and positive for lactoferrin and the amyloid P component but negative for amyloid A protein, lambda and kappa chains, and beta2-microglobulin. The seminal vesicles with obvious intravesicular hemorrhage on needle puncture were hyperintense on T1-weighted images. After hemospermia resolution T1-weighted images became diffusely hypointense. T2-weighted images were of low intensity, representing amyloid deposits. Hemospermia resolved spontaneously in all patients in an average of 14 months. Although disease recurred in 1 patient after 8 months of resolution, it disappeared after 11 months of recurrence.

CONCLUSIONS

Localized SVA with hemospermia shows hypointensity on T2-weighted MRI. Hemospermia is spontaneously resolved with the transition from hyperintense to hypointense T1-weighted MRI.

Authors+Show Affiliations

Department of Urology, Furuya Hospital, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15758775

Citation

Furuya, Seiji, et al. "Characterization of Localized Seminal Vesicle Amyloidosis Causing Hemospermia: an Analysis Using Immunohistochemistry and Magnetic Resonance Imaging." The Journal of Urology, vol. 173, no. 4, 2005, pp. 1273-7.
Furuya S, Masumori N, Furuya R, et al. Characterization of localized seminal vesicle amyloidosis causing hemospermia: an analysis using immunohistochemistry and magnetic resonance imaging. J Urol. 2005;173(4):1273-7.
Furuya, S., Masumori, N., Furuya, R., Tsukamoto, T., Isomura, H., & Tamakawa, M. (2005). Characterization of localized seminal vesicle amyloidosis causing hemospermia: an analysis using immunohistochemistry and magnetic resonance imaging. The Journal of Urology, 173(4), 1273-7.
Furuya S, et al. Characterization of Localized Seminal Vesicle Amyloidosis Causing Hemospermia: an Analysis Using Immunohistochemistry and Magnetic Resonance Imaging. J Urol. 2005;173(4):1273-7. PubMed PMID: 15758775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of localized seminal vesicle amyloidosis causing hemospermia: an analysis using immunohistochemistry and magnetic resonance imaging. AU - Furuya,Seiji, AU - Masumori,Naoya, AU - Furuya,Ryoji, AU - Tsukamoto,Taiji, AU - Isomura,Hiroshi, AU - Tamakawa,Mitsuharu, PY - 2005/3/11/pubmed PY - 2005/4/7/medline PY - 2005/3/11/entrez SP - 1273 EP - 7 JF - The Journal of urology JO - J Urol VL - 173 IS - 4 N2 - PURPOSE: We evaluated the characteristics of seminal vesicle amyloidosis (SVA) associated with hemospermia by immunohistochemistry and magnetic resonance imaging (MRI) as well as the clinical course of hemospermia. MATERIALS AND METHODS: Of 56 patients with hemospermia 12 underwent transperineal biopsy of the seminal vesicle under transrectal ultrasound monitoring. SVA was proved in 4 men 48 to 59 years old by histological and immunohistochemical examinations of specimens obtained by biopsy. Two men presented with the first episode of hemospermia and 2 presented with recurrent hemospermia. MRI at 1.5 Tesla was performed while hemospermia persisted and after its resolution. Patients were followed for 10 to 86 months with regard to the duration of hemospermia, the time of its resolution and its recurrence. RESULTS: Amyloid deposits in the subepithelial tissue of the seminal vesicles were permanganate sensitive, and positive for lactoferrin and the amyloid P component but negative for amyloid A protein, lambda and kappa chains, and beta2-microglobulin. The seminal vesicles with obvious intravesicular hemorrhage on needle puncture were hyperintense on T1-weighted images. After hemospermia resolution T1-weighted images became diffusely hypointense. T2-weighted images were of low intensity, representing amyloid deposits. Hemospermia resolved spontaneously in all patients in an average of 14 months. Although disease recurred in 1 patient after 8 months of resolution, it disappeared after 11 months of recurrence. CONCLUSIONS: Localized SVA with hemospermia shows hypointensity on T2-weighted MRI. Hemospermia is spontaneously resolved with the transition from hyperintense to hypointense T1-weighted MRI. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/15758775/Characterization_of_localized_seminal_vesicle_amyloidosis_causing_hemospermia:_an_analysis_using_immunohistochemistry_and_magnetic_resonance_imaging_ L2 - https://www.jurology.com/doi/10.1097/01.ju.0000152291.44802.9f?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -