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Reduction of blood pressure with calcium and potassium supplementation in children with salt sensitivity: a 2-year double-blinded placebo-controlled trial.
J Hum Hypertens. 2005 Jun; 19(6):479-83.JH

Abstract

An investigation of the reductive effect of blood pressure and increment of urinary sodium excretion with calcium and potassium supplementation in children with sodium sensitivity is conducted. In total of 261 school children who had completed a 2-year double-blinded, placebo-controlled trial with calcium and potassium supplementation salt sensitivity, with a salt volume expansion and contraction protocol, was determined. The results showed that in children with salt sensitivity, the increase in blood pressure in the supplementary group was lower by 4.3/4.8 mmHg than that in the placebo group (P<0.05), while no significant change was found between the supplementary group and placebo group in children with nonsalt sensitivity. With calcium and potassium supplementation, the night urinary sodium excretion in children with salt sensitivity was significantly increased (P<0.01), and it is negatively correlated with the increase in blood pressure. It was suggested that a moderate increase of calcium and potassium intake in children with salt sensitivity, through interaction with sodium, can promote urinary sodium excretion and may play contribute to the prevention of hypertension.

Authors+Show Affiliations

Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College, Xian Jiaotong University, Xian, PR China. mujjun01@sohu.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15759021

Citation

Mu, J J., et al. "Reduction of Blood Pressure With Calcium and Potassium Supplementation in Children With Salt Sensitivity: a 2-year Double-blinded Placebo-controlled Trial." Journal of Human Hypertension, vol. 19, no. 6, 2005, pp. 479-83.
Mu JJ, Liu ZQ, Liu WM, et al. Reduction of blood pressure with calcium and potassium supplementation in children with salt sensitivity: a 2-year double-blinded placebo-controlled trial. J Hum Hypertens. 2005;19(6):479-83.
Mu, J. J., Liu, Z. Q., Liu, W. M., Liang, Y. M., Yang, D. Y., Zhu, D. J., & Wang, Z. X. (2005). Reduction of blood pressure with calcium and potassium supplementation in children with salt sensitivity: a 2-year double-blinded placebo-controlled trial. Journal of Human Hypertension, 19(6), 479-83.
Mu JJ, et al. Reduction of Blood Pressure With Calcium and Potassium Supplementation in Children With Salt Sensitivity: a 2-year Double-blinded Placebo-controlled Trial. J Hum Hypertens. 2005;19(6):479-83. PubMed PMID: 15759021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of blood pressure with calcium and potassium supplementation in children with salt sensitivity: a 2-year double-blinded placebo-controlled trial. AU - Mu,J J, AU - Liu,Z Q, AU - Liu,W M, AU - Liang,Y M, AU - Yang,D Y, AU - Zhu,D J, AU - Wang,Z X, PY - 2005/3/11/pubmed PY - 2005/8/24/medline PY - 2005/3/11/entrez SP - 479 EP - 83 JF - Journal of human hypertension JO - J Hum Hypertens VL - 19 IS - 6 N2 - An investigation of the reductive effect of blood pressure and increment of urinary sodium excretion with calcium and potassium supplementation in children with sodium sensitivity is conducted. In total of 261 school children who had completed a 2-year double-blinded, placebo-controlled trial with calcium and potassium supplementation salt sensitivity, with a salt volume expansion and contraction protocol, was determined. The results showed that in children with salt sensitivity, the increase in blood pressure in the supplementary group was lower by 4.3/4.8 mmHg than that in the placebo group (P<0.05), while no significant change was found between the supplementary group and placebo group in children with nonsalt sensitivity. With calcium and potassium supplementation, the night urinary sodium excretion in children with salt sensitivity was significantly increased (P<0.01), and it is negatively correlated with the increase in blood pressure. It was suggested that a moderate increase of calcium and potassium intake in children with salt sensitivity, through interaction with sodium, can promote urinary sodium excretion and may play contribute to the prevention of hypertension. SN - 0950-9240 UR - https://www.unboundmedicine.com/medline/citation/15759021/Reduction_of_blood_pressure_with_calcium_and_potassium_supplementation_in_children_with_salt_sensitivity:_a_2_year_double_blinded_placebo_controlled_trial_ L2 - https://doi.org/10.1038/sj.jhh.1001854 DB - PRIME DP - Unbound Medicine ER -