Evaluation of the potential use of poly(ethylene oxide) as tablet- and extrudate-forming material.
AAPS PharmSci. 2004 Apr 14; 6(2):e15.AP

Abstract

The purpose of this study was to assess the potential use of poly(ethylene oxide) (PEO) as matrix-forming material for tablets and extrudates. Raw materials were characterized for size, size distribution, and shape. Tablets with 2- and 10-mm diameter were prepared by direct compression at both 13 and 38 MPa from mixtures with poly(ethylene oxide)s, a model drug (propranolol hydrochloride), and lactose. To these mixtures water was added (16%-43%) prior to extrusion in a ram extruder fit with different dies (1-, 3-, 6-, and 9-mm diameter and 4-mm length). Tablets and extrudates were characterized for work of compression or extrusion, respectively, relaxation, tensile strength, friability, and drug release. Both PEOs produced tablets easily and with different properties. Some relaxation was observed, particularly for tablets with higher amounts of PEOs. Release of the drug occurred after swelling of the matrix, and between 10% and 70% drug released, a quasi zero-order release was observed for large tablets. Extrusion was possible for formulations with PEO only with amounts of water between 16% and 50%. Both radial and axial relaxation of both plugs and extrudates were observed. Moreover, different extrusion profiles reflected the different behaviors of the different formulations. The model drug was released in the same fashion as observed for the tablets. It was possible to produce tablets by direct compression and extrudates or pellets from those extrudates from different formulations with PEO. Tablets and pellets have shown distinct properties depending upon the PEO considered. Extrusion was particularly complex with different formulations with PEO.

Authors+Show Affiliations

Pinto JF

Dep Tecnologia Farmaceutica, Faculdade de Farmacia da Universidade de Lisboa, Av. Prof. Gama Pinto, P-1649-003 Lisboa, Portugal. jfpinto@ff.ul.pt

Wunder KF

No affiliation info available

Okoloekwe A

No affiliation info available

MeSH

Delayed-Action PreparationsPolyethylene GlycolsTablets

Pub Type(s)

Comparative Study

Journal Article

Language

eng

PubMed ID

15760045

Citation

Pinto, João F., et al. "Evaluation of the Potential Use of Poly(ethylene Oxide) as Tablet- and Extrudate-forming Material." AAPS PharmSci, vol. 6, no. 2, 2004, pp. e15.

Pinto JF, Wunder KF, Okoloekwe A. Evaluation of the potential use of poly(ethylene oxide) as tablet- and extrudate-forming material. AAPS PharmSci. 2004;6(2):e15.

Pinto, J. F., Wunder, K. F., & Okoloekwe, A. (2004). Evaluation of the potential use of poly(ethylene oxide) as tablet- and extrudate-forming material. AAPS PharmSci, 6(2), e15.

Pinto JF, Wunder KF, Okoloekwe A. Evaluation of the Potential Use of Poly(ethylene Oxide) as Tablet- and Extrudate-forming Material. AAPS PharmSci. 2004 Apr 14;6(2):e15. PubMed PMID: 15760045.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Evaluation of the potential use of poly(ethylene oxide) as tablet- and extrudate-forming material. AU - Pinto,João F, AU - Wunder,Kathrin F, AU - Okoloekwe,Andrea, Y1 - 2004/04/14/ PY - 2005/3/12/pubmed PY - 2005/12/28/medline PY - 2005/3/12/entrez SP - e15 EP - e15 JF - AAPS pharmSci JO - AAPS PharmSci VL - 6 IS - 2 N2 - The purpose of this study was to assess the potential use of poly(ethylene oxide) (PEO) as matrix-forming material for tablets and extrudates. Raw materials were characterized for size, size distribution, and shape. Tablets with 2- and 10-mm diameter were prepared by direct compression at both 13 and 38 MPa from mixtures with poly(ethylene oxide)s, a model drug (propranolol hydrochloride), and lactose. To these mixtures water was added (16%-43%) prior to extrusion in a ram extruder fit with different dies (1-, 3-, 6-, and 9-mm diameter and 4-mm length). Tablets and extrudates were characterized for work of compression or extrusion, respectively, relaxation, tensile strength, friability, and drug release. Both PEOs produced tablets easily and with different properties. Some relaxation was observed, particularly for tablets with higher amounts of PEOs. Release of the drug occurred after swelling of the matrix, and between 10% and 70% drug released, a quasi zero-order release was observed for large tablets. Extrusion was possible for formulations with PEO only with amounts of water between 16% and 50%. Both radial and axial relaxation of both plugs and extrudates were observed. Moreover, different extrusion profiles reflected the different behaviors of the different formulations. The model drug was released in the same fashion as observed for the tablets. It was possible to produce tablets by direct compression and extrudates or pellets from those extrudates from different formulations with PEO. Tablets and pellets have shown distinct properties depending upon the PEO considered. Extrusion was particularly complex with different formulations with PEO. SN - 1522-1059 UR - https://www.unboundmedicine.com/medline/citation/15760045/Evaluation_of_the_potential_use_of_poly_ethylene_oxide__as_tablet__and_extrudate_forming_material_ DB - PRIME DP - Unbound Medicine ER -

Tags

Evaluation of the potential use of poly(ethylene oxide) as tablet- and extrudate-forming material.AAPS PharmSci. 2004 Apr 14; 6(2):e15.AP