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Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation.
AAPS PharmSci. 2004 May 26; 6(2):e16.AP

Abstract

The development of new direct compression excipients should include a comprehensive and rapid determination of deformation properties. The aim of this study was to characterize StarLac, a new coprocessed compound for direct compression based on lactose and maize starch. For this purpose, the effects of the base materials (maize starch and spray-dried lactose) were considered and the influence of the spray-drying process was investigated. This was performed by comparing the physical mixture of starch and spray-dried lactose at the same ratio as for StarLac. For analysis of the deformation behavior, the 3-D model and the Walker equation were applied; for verification, the Heckel equation and the pressure time function (a modified Weibull equation) were used. The advantages of StarLac are its good flowability depending on the spray-drying process, an acceptable crushing force due to its lactose content, its rapid disintegration depending on starch, and a brilliant fast release of an active ingredient, such as theophylline monohydrate. The volume-pressure deformation properties of StarLac were dependent on the lactose properties. Only at high maximum relative density (rho(rel, max)) did the influence of starch cause a change in these properties. A network-like structure can be observed using scanning electron microscopy pictures. Overall, StarLac deformed plastically with a low portion of elasticity. The physical mixture exhibited a more elastic behavior than StarLac. However, the part of the powder that was irreversibly compressed was much lower than was observed for the single substances. This behavior is caused by an interaction between the components, which in StarLac is prevented by spray drying.

Authors+Show Affiliations

Hauschild K
Faculty of Pharmacy, Institute of Pharmaceutical Technology and Biopharmacy, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Strasse 4, 06120 Halle/Saale, Germany.
Picker-Freyer KM
No affiliation info available

MeSH

Compressive StrengthElasticityExcipientsLactosePorosityPowdersPressureStarchTabletsZea mays

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15760046

Citation

Hauschild, Karsten, and Katharina M. Picker-Freyer. "Evaluation of a New Coprocessed Compound Based On Lactose and Maize Starch for Tablet Formulation." AAPS PharmSci, vol. 6, no. 2, 2004, pp. e16.
Hauschild K, Picker-Freyer KM. Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation. AAPS PharmSci. 2004;6(2):e16.
Hauschild, K., & Picker-Freyer, K. M. (2004). Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation. AAPS PharmSci, 6(2), e16.
Hauschild K, Picker-Freyer KM. Evaluation of a New Coprocessed Compound Based On Lactose and Maize Starch for Tablet Formulation. AAPS PharmSci. 2004 May 26;6(2):e16. PubMed PMID: 15760046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation. AU - Hauschild,Karsten, AU - Picker-Freyer,Katharina M, Y1 - 2004/05/26/ PY - 2005/3/12/pubmed PY - 2005/12/28/medline PY - 2005/3/12/entrez SP - e16 EP - e16 JF - AAPS pharmSci JO - AAPS PharmSci VL - 6 IS - 2 N2 - The development of new direct compression excipients should include a comprehensive and rapid determination of deformation properties. The aim of this study was to characterize StarLac, a new coprocessed compound for direct compression based on lactose and maize starch. For this purpose, the effects of the base materials (maize starch and spray-dried lactose) were considered and the influence of the spray-drying process was investigated. This was performed by comparing the physical mixture of starch and spray-dried lactose at the same ratio as for StarLac. For analysis of the deformation behavior, the 3-D model and the Walker equation were applied; for verification, the Heckel equation and the pressure time function (a modified Weibull equation) were used. The advantages of StarLac are its good flowability depending on the spray-drying process, an acceptable crushing force due to its lactose content, its rapid disintegration depending on starch, and a brilliant fast release of an active ingredient, such as theophylline monohydrate. The volume-pressure deformation properties of StarLac were dependent on the lactose properties. Only at high maximum relative density (rho(rel, max)) did the influence of starch cause a change in these properties. A network-like structure can be observed using scanning electron microscopy pictures. Overall, StarLac deformed plastically with a low portion of elasticity. The physical mixture exhibited a more elastic behavior than StarLac. However, the part of the powder that was irreversibly compressed was much lower than was observed for the single substances. This behavior is caused by an interaction between the components, which in StarLac is prevented by spray drying. SN - 1522-1059 UR - https://www.unboundmedicine.com/medline/citation/15760046/Evaluation_of_a_new_coprocessed_compound_based_on_lactose_and_maize_starch_for_tablet_formulation_ DB - PRIME DP - Unbound Medicine ER -