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Survival following dementia onset: Alzheimer's disease and vascular dementia.
J Neurol Sci. 2005 Mar 15; 229-230:43-9.JN

Abstract

Survival following the onset of dementia has been reported to vary from 3 to over 9 years. We examined mortality in 3602 participants of the Cardiovascular Health (CHS) Cognition Study in four US communities evaluated for dementia incidence between 1992 and 1999 and followed for 6.5 years. By June 2000, 33 of 62 (53.2%) participants who developed vascular dementia (VaD) had died compared to 79 of 245 (32.2%) with Alzheimer's disease (AD), 66 of 151 (43.7%) with both AD and VaD, and 429 of 2318 (18.5%) with normal cognition. Using Cox proportional hazards regression with a time-dependent covariate for dementia status adjusted for age, gender and race, individuals with VaD were more than four times as likely to die during follow-up than those with normal cognition (HR: 4.4, 95% CI: 3.1-6.3). The hazard ratios were 2.1 (95% CI: 1.6-2.7) for AD and 2.5 (95% CI: 1.9-3.3) for both types. Adjusted accelerated life models estimated median survival from dementia onset to death as 3.9 years for those with VaD, 7.1 years for AD, 5.4 years for mixed dementia, and 11.0 years for matched controls with normal cognition. While persons with VaD died primarily from cerebrovascular disease, those with AD/mixed dementia died more frequently from dementia/failure to thrive.

Authors+Show Affiliations

Department of Epidemiology, University of Washington, Seattle, WA 98115, USA. fitzpal@u.washington.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15760618

Citation

Fitzpatrick, Annette L., et al. "Survival Following Dementia Onset: Alzheimer's Disease and Vascular Dementia." Journal of the Neurological Sciences, vol. 229-230, 2005, pp. 43-9.
Fitzpatrick AL, Kuller LH, Lopez OL, et al. Survival following dementia onset: Alzheimer's disease and vascular dementia. J Neurol Sci. 2005;229-230:43-9.
Fitzpatrick, A. L., Kuller, L. H., Lopez, O. L., Kawas, C. H., & Jagust, W. (2005). Survival following dementia onset: Alzheimer's disease and vascular dementia. Journal of the Neurological Sciences, 229-230, 43-9.
Fitzpatrick AL, et al. Survival Following Dementia Onset: Alzheimer's Disease and Vascular Dementia. J Neurol Sci. 2005 Mar 15;229-230:43-9. PubMed PMID: 15760618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Survival following dementia onset: Alzheimer's disease and vascular dementia. AU - Fitzpatrick,Annette L, AU - Kuller,Lewis H, AU - Lopez,Oscar L, AU - Kawas,Claudia H, AU - Jagust,William, Y1 - 2004/12/23/ PY - 2005/3/12/pubmed PY - 2005/5/4/medline PY - 2005/3/12/entrez SP - 43 EP - 9 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 229-230 N2 - Survival following the onset of dementia has been reported to vary from 3 to over 9 years. We examined mortality in 3602 participants of the Cardiovascular Health (CHS) Cognition Study in four US communities evaluated for dementia incidence between 1992 and 1999 and followed for 6.5 years. By June 2000, 33 of 62 (53.2%) participants who developed vascular dementia (VaD) had died compared to 79 of 245 (32.2%) with Alzheimer's disease (AD), 66 of 151 (43.7%) with both AD and VaD, and 429 of 2318 (18.5%) with normal cognition. Using Cox proportional hazards regression with a time-dependent covariate for dementia status adjusted for age, gender and race, individuals with VaD were more than four times as likely to die during follow-up than those with normal cognition (HR: 4.4, 95% CI: 3.1-6.3). The hazard ratios were 2.1 (95% CI: 1.6-2.7) for AD and 2.5 (95% CI: 1.9-3.3) for both types. Adjusted accelerated life models estimated median survival from dementia onset to death as 3.9 years for those with VaD, 7.1 years for AD, 5.4 years for mixed dementia, and 11.0 years for matched controls with normal cognition. While persons with VaD died primarily from cerebrovascular disease, those with AD/mixed dementia died more frequently from dementia/failure to thrive. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/15760618/Survival_following_dementia_onset:_Alzheimer's_disease_and_vascular_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(04)00445-9 DB - PRIME DP - Unbound Medicine ER -