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Patterns of memory impairment and perseverative behavior discriminate early Alzheimer's disease from subcortical vascular dementia.
J Neurol Sci. 2005 Mar 15; 229-230:75-9.JN

Abstract

Previous research suggests that the neuropsychological deficits in Alzheimer's disease (AD) are different from that of vascular dementia (VaD), especially with respect to memory, language and executive functions, but negative findings were reported. Our objective was to clarify the cognitive syndrome in AD and VaD in the early stage of these disorders. We investigated 45 patients with early AD, 23 patients with subcortical VaD and 35 normal controls. All subjects were assessed with neuropsychological battery designed to measure memory, language, praxis and executive functions. Patients with AD had significantly worse scores on Story Recall (p<0.02) and on all measures of the Free and Cued Selective Reminding Test (p<0.03 to 0.001) than did patients with VaD, as well as greater number of perseverations (p<0.02) on category fluency. Conversely, VaD patients had more perseverations (p<0.02) on the Modified Card Sorting Test. Despite the similar degree of overall cognitive deterioration, the findings show more impaired retrieval from long-term storage in AD than in VaD. Moreover, the data suggest that AD and subcortical VaD affect perseverative behavior in a different fashion. These results may be helpful in differentiating AD from VaD in the early stage of these disorders, when mental impairments are not pervasive yet.

Authors+Show Affiliations

INSERM U.610, Paris, France. traykov_l@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15760623

Citation

Traykov, Latchezar, et al. "Patterns of Memory Impairment and Perseverative Behavior Discriminate Early Alzheimer's Disease From Subcortical Vascular Dementia." Journal of the Neurological Sciences, vol. 229-230, 2005, pp. 75-9.
Traykov L, Baudic S, Raoux N, et al. Patterns of memory impairment and perseverative behavior discriminate early Alzheimer's disease from subcortical vascular dementia. J Neurol Sci. 2005;229-230:75-9.
Traykov, L., Baudic, S., Raoux, N., Latour, F., Rieu, D., Smagghe, A., & Rigaud, A. S. (2005). Patterns of memory impairment and perseverative behavior discriminate early Alzheimer's disease from subcortical vascular dementia. Journal of the Neurological Sciences, 229-230, 75-9.
Traykov L, et al. Patterns of Memory Impairment and Perseverative Behavior Discriminate Early Alzheimer's Disease From Subcortical Vascular Dementia. J Neurol Sci. 2005 Mar 15;229-230:75-9. PubMed PMID: 15760623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patterns of memory impairment and perseverative behavior discriminate early Alzheimer's disease from subcortical vascular dementia. AU - Traykov,Latchezar, AU - Baudic,Sophie, AU - Raoux,Nadine, AU - Latour,Florence, AU - Rieu,Dorothée, AU - Smagghe,Alain, AU - Rigaud,Anne-Sophie, Y1 - 2004/12/19/ PY - 2005/3/12/pubmed PY - 2005/5/4/medline PY - 2005/3/12/entrez SP - 75 EP - 9 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 229-230 N2 - Previous research suggests that the neuropsychological deficits in Alzheimer's disease (AD) are different from that of vascular dementia (VaD), especially with respect to memory, language and executive functions, but negative findings were reported. Our objective was to clarify the cognitive syndrome in AD and VaD in the early stage of these disorders. We investigated 45 patients with early AD, 23 patients with subcortical VaD and 35 normal controls. All subjects were assessed with neuropsychological battery designed to measure memory, language, praxis and executive functions. Patients with AD had significantly worse scores on Story Recall (p<0.02) and on all measures of the Free and Cued Selective Reminding Test (p<0.03 to 0.001) than did patients with VaD, as well as greater number of perseverations (p<0.02) on category fluency. Conversely, VaD patients had more perseverations (p<0.02) on the Modified Card Sorting Test. Despite the similar degree of overall cognitive deterioration, the findings show more impaired retrieval from long-term storage in AD than in VaD. Moreover, the data suggest that AD and subcortical VaD affect perseverative behavior in a different fashion. These results may be helpful in differentiating AD from VaD in the early stage of these disorders, when mental impairments are not pervasive yet. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/15760623/Patterns_of_memory_impairment_and_perseverative_behavior_discriminate_early_Alzheimer's_disease_from_subcortical_vascular_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(04)00428-9 DB - PRIME DP - Unbound Medicine ER -