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Comparison of fat storage between Fischer 344 and obesity-resistant Lou/C rats fed different diets.
Obes Res 2005; 13(1):3-10OR

Abstract

OBJECTIVE

We aimed to characterize further the Lou/C (LOU) and Fischer 344 (F344) rat strains for nutritional traits to validate their use as contrasting strains for molecular genetic studies.

RESEARCH METHODS AND PROCEDURES

Five batches of LOU and F344 rats were used to measure caloric intake, weight gain, and body composition when fed a chow diet, a self-selection diet (together with the study of preferences for macronutrients), hypercaloric diets, and a chow diet in a cold environment.

RESULTS

Despite a higher caloric intake when fed a chow diet, LOU rats showed a lower weight gain, final body weight, and percentage of fat tissue, together with a higher percentage of carcass weight, than F344 rats. When fed a self-selection diet, LOU males ingested less protein and more fat than F344 males, and the reverse was observed for females. In this condition, feed efficiency was reduced in LOU but increased in F344 rats compared with the chow diet. Diet-induced obesity was observed in F344 rats but not in LOU rats fed hypercaloric diets. In a cold environment, both LOU and F344 rats displayed an increased percentage of brown adipose tissue compared with control groups, together with a higher caloric intake.

DISCUSSION

The study shows robust nutritional differences between the LOU rat, a lean strain with a low feed efficiency and resistant to diet-induced obesity, and the contrasting F344 rat strain. It also shows the interest in these strains for studying the genetic components of resistance to obesity.

Authors+Show Affiliations

Laboratory for Neurogenetics and Stress, UMR 1243 INRA, Université Victor Segalen Bordeaux 2, Bordeaux cedex, France.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15761158

Citation

Héliès, Jean-Marie, et al. "Comparison of Fat Storage Between Fischer 344 and Obesity-resistant Lou/C Rats Fed Different Diets." Obesity Research, vol. 13, no. 1, 2005, pp. 3-10.
Héliès JM, Diane A, Langlois A, et al. Comparison of fat storage between Fischer 344 and obesity-resistant Lou/C rats fed different diets. Obes Res. 2005;13(1):3-10.
Héliès, J. M., Diane, A., Langlois, A., Larue-Achagiotis, C., Fromentin, G., Tomé, D., ... Marissal-Arvy, N. (2005). Comparison of fat storage between Fischer 344 and obesity-resistant Lou/C rats fed different diets. Obesity Research, 13(1), pp. 3-10.
Héliès JM, et al. Comparison of Fat Storage Between Fischer 344 and Obesity-resistant Lou/C Rats Fed Different Diets. Obes Res. 2005;13(1):3-10. PubMed PMID: 15761158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of fat storage between Fischer 344 and obesity-resistant Lou/C rats fed different diets. AU - Héliès,Jean-Marie, AU - Diane,Abdoulaye, AU - Langlois,Allan, AU - Larue-Achagiotis,Christiane, AU - Fromentin,Gilles, AU - Tomé,Daniel, AU - Mormède,Pierre, AU - Marissal-Arvy,Nathalie, PY - 2005/3/12/pubmed PY - 2005/6/24/medline PY - 2005/3/12/entrez SP - 3 EP - 10 JF - Obesity research JO - Obes. Res. VL - 13 IS - 1 N2 - OBJECTIVE: We aimed to characterize further the Lou/C (LOU) and Fischer 344 (F344) rat strains for nutritional traits to validate their use as contrasting strains for molecular genetic studies. RESEARCH METHODS AND PROCEDURES: Five batches of LOU and F344 rats were used to measure caloric intake, weight gain, and body composition when fed a chow diet, a self-selection diet (together with the study of preferences for macronutrients), hypercaloric diets, and a chow diet in a cold environment. RESULTS: Despite a higher caloric intake when fed a chow diet, LOU rats showed a lower weight gain, final body weight, and percentage of fat tissue, together with a higher percentage of carcass weight, than F344 rats. When fed a self-selection diet, LOU males ingested less protein and more fat than F344 males, and the reverse was observed for females. In this condition, feed efficiency was reduced in LOU but increased in F344 rats compared with the chow diet. Diet-induced obesity was observed in F344 rats but not in LOU rats fed hypercaloric diets. In a cold environment, both LOU and F344 rats displayed an increased percentage of brown adipose tissue compared with control groups, together with a higher caloric intake. DISCUSSION: The study shows robust nutritional differences between the LOU rat, a lean strain with a low feed efficiency and resistant to diet-induced obesity, and the contrasting F344 rat strain. It also shows the interest in these strains for studying the genetic components of resistance to obesity. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/15761158/Comparison_of_fat_storage_between_Fischer_344_and_obesity_resistant_Lou/C_rats_fed_different_diets_ L2 - https://doi.org/10.1038/oby.2005.3 DB - PRIME DP - Unbound Medicine ER -