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Cell death in HIV dementia.
Cell Death Differ. 2005 Aug; 12 Suppl 1:893-904.CD

Abstract

Many patients infected with human immunodeficiency virus type-1 (HIV-1) suffer cognitive impairment ranging from mild to severe (HIV dementia), which may result from neuronal death in the basal ganglia, cerebral cortex and hippocampus. HIV-1 does not kill neurons by infecting them. Instead, viral proteins released from infected glial cells, macrophages and/or stem cells may directly kill neurons or may increase their vulnerability to other cell death stimuli. By binding to and/or indirectly activating cell surface receptors such as CXCR4 and the N-methyl-D-aspartate receptor, the HIV-1 proteins gp120 and Tat may trigger neuronal apoptosis and excitotoxicity as a result of oxidative stress, perturbed cellular calcium homeostasis and mitochondrial alterations. Membrane lipid metabolism and inflammation may also play important roles in determining whether neurons live or die in HIV-1-infected patients. Drugs and diets that target oxidative stress, excitotoxicity, inflammation and lipid metabolism are in development for the treatment of HIV-1 patients.

Authors+Show Affiliations

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. mattsonm@grc.nia.nih.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15761472

Citation

Mattson, M P., et al. "Cell Death in HIV Dementia." Cell Death and Differentiation, vol. 12 Suppl 1, 2005, pp. 893-904.
Mattson MP, Haughey NJ, Nath A. Cell death in HIV dementia. Cell Death Differ. 2005;12 Suppl 1:893-904.
Mattson, M. P., Haughey, N. J., & Nath, A. (2005). Cell death in HIV dementia. Cell Death and Differentiation, 12 Suppl 1, 893-904.
Mattson MP, Haughey NJ, Nath A. Cell Death in HIV Dementia. Cell Death Differ. 2005;12 Suppl 1:893-904. PubMed PMID: 15761472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cell death in HIV dementia. AU - Mattson,M P, AU - Haughey,N J, AU - Nath,A, PY - 2005/3/12/pubmed PY - 2006/5/24/medline PY - 2005/3/12/entrez SP - 893 EP - 904 JF - Cell death and differentiation JO - Cell Death Differ VL - 12 Suppl 1 N2 - Many patients infected with human immunodeficiency virus type-1 (HIV-1) suffer cognitive impairment ranging from mild to severe (HIV dementia), which may result from neuronal death in the basal ganglia, cerebral cortex and hippocampus. HIV-1 does not kill neurons by infecting them. Instead, viral proteins released from infected glial cells, macrophages and/or stem cells may directly kill neurons or may increase their vulnerability to other cell death stimuli. By binding to and/or indirectly activating cell surface receptors such as CXCR4 and the N-methyl-D-aspartate receptor, the HIV-1 proteins gp120 and Tat may trigger neuronal apoptosis and excitotoxicity as a result of oxidative stress, perturbed cellular calcium homeostasis and mitochondrial alterations. Membrane lipid metabolism and inflammation may also play important roles in determining whether neurons live or die in HIV-1-infected patients. Drugs and diets that target oxidative stress, excitotoxicity, inflammation and lipid metabolism are in development for the treatment of HIV-1 patients. SN - 1350-9047 UR - https://www.unboundmedicine.com/medline/citation/15761472/Cell_death_in_HIV_dementia_ L2 - https://doi.org/10.1038/sj.cdd.4401577 DB - PRIME DP - Unbound Medicine ER -