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Roxarsone and transformation products in chicken manure: determination by capillary electrophoresis-inductively coupled plasma-mass spectrometry.
Electrophoresis. 2005 Apr; 26(7-8):1606-14.E

Abstract

The determination of the animal feed additive roxarsone (3-nitro-4-hydroxyphenylarsonic acid) and six of its possible transformation products (arsenite, arsenate, monomethylarsonate, dimethylarsinate, 3-amino-4-hydroxyphenylarsonic acid, and 4-hydroxyphenylarsonic acid) in chicken manure was investigated using capillary electrophoresis-inductively coupled plasma-mass spectrometry (CE-ICP-MS). Initial method development was conducted using ultraviolet (UV) detection for ruggedness and time efficiency. Separation of these seven arsenic species was effected using a 20 mM phosphate buffer at pH 5.7. The CE-ICP-MS limits of detection in terms of As for each of the species was in the low microg.L(-1) range, corresponding to absolute detection limits in the range 20-70 fg As (based on a 23 nL injection). Overall, the method developed in this study provides high selectivity and low limits of detection (1-3 microg.L(-1) or low-ppb, based on As), uses small sample volume (low nL), and produces minimal wastes.

Authors+Show Affiliations

Rosal CG
U.S. Environmental Protection Agency, National Exposure Research Laboratory, Environmental Sciences Division, Las Vegas, NV 89119, USA. rosal.charlita@epa.gov
Momplaisir GM
No affiliation info available
Heithmar EM
No affiliation info available

MeSH

AnimalsChickensCoccidiostatsElectrophoresis, CapillaryManureMass SpectrometryRoxarsoneSensitivity and SpecificitySpectrophotometry, Ultraviolet

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15761918

Citation

Rosal, Charlita G., et al. "Roxarsone and Transformation Products in Chicken Manure: Determination By Capillary Electrophoresis-inductively Coupled Plasma-mass Spectrometry." Electrophoresis, vol. 26, no. 7-8, 2005, pp. 1606-14.
Rosal CG, Momplaisir GM, Heithmar EM. Roxarsone and transformation products in chicken manure: determination by capillary electrophoresis-inductively coupled plasma-mass spectrometry. Electrophoresis. 2005;26(7-8):1606-14.
Rosal, C. G., Momplaisir, G. M., & Heithmar, E. M. (2005). Roxarsone and transformation products in chicken manure: determination by capillary electrophoresis-inductively coupled plasma-mass spectrometry. Electrophoresis, 26(7-8), 1606-14.
Rosal CG, Momplaisir GM, Heithmar EM. Roxarsone and Transformation Products in Chicken Manure: Determination By Capillary Electrophoresis-inductively Coupled Plasma-mass Spectrometry. Electrophoresis. 2005;26(7-8):1606-14. PubMed PMID: 15761918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Roxarsone and transformation products in chicken manure: determination by capillary electrophoresis-inductively coupled plasma-mass spectrometry. AU - Rosal,Charlita G, AU - Momplaisir,Georges-Marie, AU - Heithmar,Edward M, PY - 2005/3/12/pubmed PY - 2005/9/30/medline PY - 2005/3/12/entrez SP - 1606 EP - 14 JF - Electrophoresis JO - Electrophoresis VL - 26 IS - 7-8 N2 - The determination of the animal feed additive roxarsone (3-nitro-4-hydroxyphenylarsonic acid) and six of its possible transformation products (arsenite, arsenate, monomethylarsonate, dimethylarsinate, 3-amino-4-hydroxyphenylarsonic acid, and 4-hydroxyphenylarsonic acid) in chicken manure was investigated using capillary electrophoresis-inductively coupled plasma-mass spectrometry (CE-ICP-MS). Initial method development was conducted using ultraviolet (UV) detection for ruggedness and time efficiency. Separation of these seven arsenic species was effected using a 20 mM phosphate buffer at pH 5.7. The CE-ICP-MS limits of detection in terms of As for each of the species was in the low microg.L(-1) range, corresponding to absolute detection limits in the range 20-70 fg As (based on a 23 nL injection). Overall, the method developed in this study provides high selectivity and low limits of detection (1-3 microg.L(-1) or low-ppb, based on As), uses small sample volume (low nL), and produces minimal wastes. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/15761918/Roxarsone_and_transformation_products_in_chicken_manure:_determination_by_capillary_electrophoresis_inductively_coupled_plasma_mass_spectrometry_ DB - PRIME DP - Unbound Medicine ER -