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Very short term dehydroepiandrosterone treatment in female adrenal failure: impact on carbohydrate, lipid and protein metabolism.
Eur J Endocrinol. 2005 Jan; 152(1):77-85.EJ

Abstract

OBJECTIVE

In female adrenal insufficiency, dehydroepiandrosterone (DHEA) secretion is impaired and circulating androgen levels are severely reduced. We wanted to analyse the acute effects of physiological DHEA substitution on substrate metabolism.

DESIGN

We studied nine females with adrenal insufficiency after 9 days of oral DHEA replacement (50 mg/day) in a double-blind, placebo-controlled crossover study.

METHODS

Whole body and regional substrate metabolism was assayed in the basal state and during a euglycemic hyperinsulinemic glucose clamp by means of isotope dilution techniques (glucose, phenylalanine, tyrosine), indirect calorimetry and in situ lipolysis (microdialysis technique).

RESULTS

DHEA treatment normalized the levels of all androgens. Basal and insulin-stimulated total energy expenditure and rates of protein, lipid and glucose oxidation were unaffected by DHEA. Whole body turnover of glucose and protein were also unaffected by DHEA. Forearm breakdown of protein was reduced by insulin to the same extent after placebo and DHEA. Insulin sensitivity as expressed by the glucose infusion rate during the euglycemic clamp was similar after placebo and DHEA. Finally, the interstitial release of glycerol in adipose tissue was not significantly influenced by DHEA.

CONCLUSIONS

Short-term oral DHEA replacement in women with adrenal insufficiency was not associated with measurable changes in total or regional substrate metabolism.

Authors+Show Affiliations

Medical Department M, Arhus Sygehus, Arhus University Hospital, Arhus, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15762190

Citation

Christiansen, Jens Juel, et al. "Very Short Term Dehydroepiandrosterone Treatment in Female Adrenal Failure: Impact On Carbohydrate, Lipid and Protein Metabolism." European Journal of Endocrinology, vol. 152, no. 1, 2005, pp. 77-85.
Christiansen JJ, Gravholt CH, Fisker S, et al. Very short term dehydroepiandrosterone treatment in female adrenal failure: impact on carbohydrate, lipid and protein metabolism. Eur J Endocrinol. 2005;152(1):77-85.
Christiansen, J. J., Gravholt, C. H., Fisker, S., Møller, N., Andersen, M., Svenstrup, B., Bennett, P., Ivarsen, P., Christiansen, J. S., & Jørgensen, J. O. (2005). Very short term dehydroepiandrosterone treatment in female adrenal failure: impact on carbohydrate, lipid and protein metabolism. European Journal of Endocrinology, 152(1), 77-85.
Christiansen JJ, et al. Very Short Term Dehydroepiandrosterone Treatment in Female Adrenal Failure: Impact On Carbohydrate, Lipid and Protein Metabolism. Eur J Endocrinol. 2005;152(1):77-85. PubMed PMID: 15762190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Very short term dehydroepiandrosterone treatment in female adrenal failure: impact on carbohydrate, lipid and protein metabolism. AU - Christiansen,Jens Juel, AU - Gravholt,Claus Højbjerg, AU - Fisker,Sanne, AU - Møller,Niels, AU - Andersen,Marianne, AU - Svenstrup,Birgit, AU - Bennett,Paul, AU - Ivarsen,Per, AU - Christiansen,Jens Sandahl, AU - Jørgensen,Jens Otto Lunde, PY - 2005/3/15/pubmed PY - 2005/4/1/medline PY - 2005/3/15/entrez SP - 77 EP - 85 JF - European journal of endocrinology JO - Eur J Endocrinol VL - 152 IS - 1 N2 - OBJECTIVE: In female adrenal insufficiency, dehydroepiandrosterone (DHEA) secretion is impaired and circulating androgen levels are severely reduced. We wanted to analyse the acute effects of physiological DHEA substitution on substrate metabolism. DESIGN: We studied nine females with adrenal insufficiency after 9 days of oral DHEA replacement (50 mg/day) in a double-blind, placebo-controlled crossover study. METHODS: Whole body and regional substrate metabolism was assayed in the basal state and during a euglycemic hyperinsulinemic glucose clamp by means of isotope dilution techniques (glucose, phenylalanine, tyrosine), indirect calorimetry and in situ lipolysis (microdialysis technique). RESULTS: DHEA treatment normalized the levels of all androgens. Basal and insulin-stimulated total energy expenditure and rates of protein, lipid and glucose oxidation were unaffected by DHEA. Whole body turnover of glucose and protein were also unaffected by DHEA. Forearm breakdown of protein was reduced by insulin to the same extent after placebo and DHEA. Insulin sensitivity as expressed by the glucose infusion rate during the euglycemic clamp was similar after placebo and DHEA. Finally, the interstitial release of glycerol in adipose tissue was not significantly influenced by DHEA. CONCLUSIONS: Short-term oral DHEA replacement in women with adrenal insufficiency was not associated with measurable changes in total or regional substrate metabolism. SN - 0804-4643 UR - https://www.unboundmedicine.com/medline/citation/15762190/Very_short_term_dehydroepiandrosterone_treatment_in_female_adrenal_failure:_impact_on_carbohydrate_lipid_and_protein_metabolism_ L2 - https://eje.bioscientifica.com/doi/10.1530/eje.1.01810 DB - PRIME DP - Unbound Medicine ER -