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Cocrystallization of random copolymers of omega-pentadecalactone and epsilon-caprolactone synthesized by lipase catalysis.
Biomacromolecules 2005 Mar-Apr; 6(2):902-7B

Abstract

Random copolymers were prepared by Candida antarctica lipase B (Novozyme-435) catalyzed copolymerization of omega-pentadecalactone (PDL) with epsilon-caprolactone (CL). Over the whole composition range PDL-CL copolymers are highly crystalline (melting enthalpy by differential scanning calorimetry, above 100 J/g; crystallinity degree by wide-angle X-ray scattering, WAXS, 60-70%). The copolymers melt at temperatures that linearly decrease with composition from that of poly(omega-pentadecalactone) (PPDL; 97 degrees C) to that of poly(epsilon-caprolactone) (PCL; 59 degrees C). The WAXS profiles of PCL and PPDL homopolymers are very similar, except for the presence in PPDL of the (001) reflection at 2theta = 4.58 degrees that corresponds to a 19.3 angstroms periodicity in the chain direction. In PDL-CL copolymers the intensity of this reflection decreases with increasing content of CL units and vanishes at 50 mol % CL, as a result of randomization of the ester group alignment and loss of chain periodicity. PDL-CL copolymers crystallize in a lattice that gradually changes from that of one homopolymer to that of the other, owing to comonomer isomorphous substitution. Cocrystallization of comonomer units is also shown by a random PDL-CL copolymer obtained in a polymerization/transesterification reaction catalyzed by C. antarctica lipase B (Novozyme-435) starting from preformed PCL and PDL monomer.

Authors+Show Affiliations

Department of Chemistry G. Ciamician and INSTM UdR Bologna, University of Bologna, via Selmi 2, 40126 Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15762658

Citation

Ceccorulli, Giuseppina, et al. "Cocrystallization of Random Copolymers of Omega-pentadecalactone and Epsilon-caprolactone Synthesized By Lipase Catalysis." Biomacromolecules, vol. 6, no. 2, 2005, pp. 902-7.
Ceccorulli G, Scandola M, Kumar A, et al. Cocrystallization of random copolymers of omega-pentadecalactone and epsilon-caprolactone synthesized by lipase catalysis. Biomacromolecules. 2005;6(2):902-7.
Ceccorulli, G., Scandola, M., Kumar, A., Kalra, B., & Gross, R. A. (2005). Cocrystallization of random copolymers of omega-pentadecalactone and epsilon-caprolactone synthesized by lipase catalysis. Biomacromolecules, 6(2), pp. 902-7.
Ceccorulli G, et al. Cocrystallization of Random Copolymers of Omega-pentadecalactone and Epsilon-caprolactone Synthesized By Lipase Catalysis. Biomacromolecules. 2005;6(2):902-7. PubMed PMID: 15762658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cocrystallization of random copolymers of omega-pentadecalactone and epsilon-caprolactone synthesized by lipase catalysis. AU - Ceccorulli,Giuseppina, AU - Scandola,Mariastella, AU - Kumar,Ajay, AU - Kalra,Bhanu, AU - Gross,Richard A, PY - 2005/3/15/pubmed PY - 2005/8/19/medline PY - 2005/3/15/entrez SP - 902 EP - 7 JF - Biomacromolecules JO - Biomacromolecules VL - 6 IS - 2 N2 - Random copolymers were prepared by Candida antarctica lipase B (Novozyme-435) catalyzed copolymerization of omega-pentadecalactone (PDL) with epsilon-caprolactone (CL). Over the whole composition range PDL-CL copolymers are highly crystalline (melting enthalpy by differential scanning calorimetry, above 100 J/g; crystallinity degree by wide-angle X-ray scattering, WAXS, 60-70%). The copolymers melt at temperatures that linearly decrease with composition from that of poly(omega-pentadecalactone) (PPDL; 97 degrees C) to that of poly(epsilon-caprolactone) (PCL; 59 degrees C). The WAXS profiles of PCL and PPDL homopolymers are very similar, except for the presence in PPDL of the (001) reflection at 2theta = 4.58 degrees that corresponds to a 19.3 angstroms periodicity in the chain direction. In PDL-CL copolymers the intensity of this reflection decreases with increasing content of CL units and vanishes at 50 mol % CL, as a result of randomization of the ester group alignment and loss of chain periodicity. PDL-CL copolymers crystallize in a lattice that gradually changes from that of one homopolymer to that of the other, owing to comonomer isomorphous substitution. Cocrystallization of comonomer units is also shown by a random PDL-CL copolymer obtained in a polymerization/transesterification reaction catalyzed by C. antarctica lipase B (Novozyme-435) starting from preformed PCL and PDL monomer. SN - 1525-7797 UR - https://www.unboundmedicine.com/medline/citation/15762658/Cocrystallization_of_random_copolymers_of_omega_pentadecalactone_and_epsilon_caprolactone_synthesized_by_lipase_catalysis_ L2 - https://dx.doi.org/10.1021/bm0493279 DB - PRIME DP - Unbound Medicine ER -