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The GABA-benzodiazepine receptor complex: structure, function, and role in anxiety.
J Clin Psychiatry. 2005; 66 Suppl 2:14-20.JC

Abstract

Benzodiazepines bind to a specific site on the gamma-aminobutyric acid (GABA)-benzodiazepine receptor complex. This complex has been implicated in the pathophysiology of anxiety by numerous pre-clinical and clinical studies. Preclinical studies have shown that there are multiple molecular forms of this receptor complex, that these genetically coded variations are linked to specific actions of the benzodiazepines, and that receptors are located in neuroanatomical areas known to mediate the anxiety response in animals and humans. Human studies have shown that patients with pathologic anxiety have anomalous responses to drugs that specifically bind to these receptors and have reduced numbers of benzodiazepine receptors in key brain areas that regulate anxiety responses. More recent preclinical studies suggest that molecular alterations in this receptor complex may produce findings in animals similar to those observed in anxious humans. Finally, chronic treatment with benzodiazepines causes the development of tolerance, which may be associated with molecular changes and a pharmacologic response profile similar to that observed in pathologically anxious humans.

Authors+Show Affiliations

Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98104, USA. roybyrne@u.washington.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15762815

Citation

Roy-Byrne, Peter P.. "The GABA-benzodiazepine Receptor Complex: Structure, Function, and Role in Anxiety." The Journal of Clinical Psychiatry, vol. 66 Suppl 2, 2005, pp. 14-20.
Roy-Byrne PP. The GABA-benzodiazepine receptor complex: structure, function, and role in anxiety. J Clin Psychiatry. 2005;66 Suppl 2:14-20.
Roy-Byrne, P. P. (2005). The GABA-benzodiazepine receptor complex: structure, function, and role in anxiety. The Journal of Clinical Psychiatry, 66 Suppl 2, 14-20.
Roy-Byrne PP. The GABA-benzodiazepine Receptor Complex: Structure, Function, and Role in Anxiety. J Clin Psychiatry. 2005;66 Suppl 2:14-20. PubMed PMID: 15762815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The GABA-benzodiazepine receptor complex: structure, function, and role in anxiety. A1 - Roy-Byrne,Peter P, PY - 2005/3/15/pubmed PY - 2005/3/26/medline PY - 2005/3/15/entrez SP - 14 EP - 20 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 66 Suppl 2 N2 - Benzodiazepines bind to a specific site on the gamma-aminobutyric acid (GABA)-benzodiazepine receptor complex. This complex has been implicated in the pathophysiology of anxiety by numerous pre-clinical and clinical studies. Preclinical studies have shown that there are multiple molecular forms of this receptor complex, that these genetically coded variations are linked to specific actions of the benzodiazepines, and that receptors are located in neuroanatomical areas known to mediate the anxiety response in animals and humans. Human studies have shown that patients with pathologic anxiety have anomalous responses to drugs that specifically bind to these receptors and have reduced numbers of benzodiazepine receptors in key brain areas that regulate anxiety responses. More recent preclinical studies suggest that molecular alterations in this receptor complex may produce findings in animals similar to those observed in anxious humans. Finally, chronic treatment with benzodiazepines causes the development of tolerance, which may be associated with molecular changes and a pharmacologic response profile similar to that observed in pathologically anxious humans. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/15762815/The_GABA_benzodiazepine_receptor_complex:_structure_function_and_role_in_anxiety_ L2 - http://www.psychiatrist.com/jcp/article/pages/2005/v66s02/v66s0203.aspx DB - PRIME DP - Unbound Medicine ER -