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Morphology of alcoholic liver disease.
Clin Liver Dis. 2005 Feb; 9(1):37-53.CL

Abstract

The major pathologic manifestations of alcoholic liver injury have been well described, and include three major lesions: steatosis (fatty liver), steatohepatitis (formerly alcoholic hepatitis), and cirrhosis. Recent attention to the problem of nonalcoholic fatty liver disease (NAFLD) in individuals with obesity, diabetes, and other risk factors has shed light on the mechanisms of cellular injury associated with hepatic steatosis and on the potential pathways to steatohepatitis and cirrhosis. Pathologists need to be familiar with the spectrum of changes seen in steatohepatitis, including hepatocyte ballooning, Mallory bodies, mixed inflammatory cell infiltrates, and a distinctive perivenular and pericellular "chicken-wire" fibrosis. These features and other less common histopathologic lesions in the liver are reviewed and illustrated.

Authors+Show Affiliations

Columbia University, Department of Surgical Pathology, PH 1564W, 630 W 168th Streest, VC 14th Floor, Room 215, New York, NY 10032, USA. jhl3@columbia.edu

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

15763228

Citation

Lefkowitch, Jay H.. "Morphology of Alcoholic Liver Disease." Clinics in Liver Disease, vol. 9, no. 1, 2005, pp. 37-53.
Lefkowitch JH. Morphology of alcoholic liver disease. Clin Liver Dis. 2005;9(1):37-53.
Lefkowitch, J. H. (2005). Morphology of alcoholic liver disease. Clinics in Liver Disease, 9(1), 37-53.
Lefkowitch JH. Morphology of Alcoholic Liver Disease. Clin Liver Dis. 2005;9(1):37-53. PubMed PMID: 15763228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphology of alcoholic liver disease. A1 - Lefkowitch,Jay H, PY - 2005/3/15/pubmed PY - 2005/5/19/medline PY - 2005/3/15/entrez SP - 37 EP - 53 JF - Clinics in liver disease JO - Clin Liver Dis VL - 9 IS - 1 N2 - The major pathologic manifestations of alcoholic liver injury have been well described, and include three major lesions: steatosis (fatty liver), steatohepatitis (formerly alcoholic hepatitis), and cirrhosis. Recent attention to the problem of nonalcoholic fatty liver disease (NAFLD) in individuals with obesity, diabetes, and other risk factors has shed light on the mechanisms of cellular injury associated with hepatic steatosis and on the potential pathways to steatohepatitis and cirrhosis. Pathologists need to be familiar with the spectrum of changes seen in steatohepatitis, including hepatocyte ballooning, Mallory bodies, mixed inflammatory cell infiltrates, and a distinctive perivenular and pericellular "chicken-wire" fibrosis. These features and other less common histopathologic lesions in the liver are reviewed and illustrated. SN - 1089-3261 UR - https://www.unboundmedicine.com/medline/citation/15763228/Morphology_of_alcoholic_liver_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1089-3261(04)00118-7 DB - PRIME DP - Unbound Medicine ER -