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The effect of scolicidal agents on liver and biliary tree (experimental study).
J Invest Surg 2004 Nov-Dec; 17(6):323-6JI

Abstract

Hydatid disease of the liver is a parasitic infection. Surgery still remains as the primary choice of treatment. Caustic sclerosing cholangitis is reported following surgical treatment. Hypertonic saline (20%), povidone iodine (1%), and silver nitrate (0.5%) are extensively used as scolicidal solutions. The effects of these scolicidal agents on liver and biliary tree are investigated by direct injection into the common bile duct of rats. At the end of 15 wk, liver function tests, cholangiography, and histopathological examination of the liver and biliary tree were performed. Liver function tests were within normal limits, except elevation of alkaline phosphatase in 2 and 1 rats of the silver nitrate and povidone iodine groups, respectively. Differences were not statistically significant (p > .05). Cholangiograms of the rats in all groups were normal. Histopathologic changes comprising low-grade inflammatory changes were induced in all study groups. The intensity of the lesions were more remarkable with silver nitrate and minimal with hypertonic saline. We suggest that direct injection of scolicidal agents into the cyst should be avoided particulary in case of biliary communication. If this is to be practiced, hypertonic saline should be preferred as a scolicidal agent.

Authors+Show Affiliations

Department of Surgery, Vakif Gureba Training Hospital, Istanbul, Turkey. mdmsahin@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15764499

Citation

Sahin, Mustafa, et al. "The Effect of Scolicidal Agents On Liver and Biliary Tree (experimental Study)." Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research, vol. 17, no. 6, 2004, pp. 323-6.
Sahin M, Eryilmaz R, Bulbuloglu E. The effect of scolicidal agents on liver and biliary tree (experimental study). J Invest Surg. 2004;17(6):323-6.
Sahin, M., Eryilmaz, R., & Bulbuloglu, E. (2004). The effect of scolicidal agents on liver and biliary tree (experimental study). Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research, 17(6), pp. 323-6.
Sahin M, Eryilmaz R, Bulbuloglu E. The Effect of Scolicidal Agents On Liver and Biliary Tree (experimental Study). J Invest Surg. 2004;17(6):323-6. PubMed PMID: 15764499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of scolicidal agents on liver and biliary tree (experimental study). AU - Sahin,Mustafa, AU - Eryilmaz,Ramazan, AU - Bulbuloglu,Ertan, PY - 2005/3/15/pubmed PY - 2005/4/22/medline PY - 2005/3/15/entrez SP - 323 EP - 6 JF - Journal of investigative surgery : the official journal of the Academy of Surgical Research JO - J Invest Surg VL - 17 IS - 6 N2 - Hydatid disease of the liver is a parasitic infection. Surgery still remains as the primary choice of treatment. Caustic sclerosing cholangitis is reported following surgical treatment. Hypertonic saline (20%), povidone iodine (1%), and silver nitrate (0.5%) are extensively used as scolicidal solutions. The effects of these scolicidal agents on liver and biliary tree are investigated by direct injection into the common bile duct of rats. At the end of 15 wk, liver function tests, cholangiography, and histopathological examination of the liver and biliary tree were performed. Liver function tests were within normal limits, except elevation of alkaline phosphatase in 2 and 1 rats of the silver nitrate and povidone iodine groups, respectively. Differences were not statistically significant (p > .05). Cholangiograms of the rats in all groups were normal. Histopathologic changes comprising low-grade inflammatory changes were induced in all study groups. The intensity of the lesions were more remarkable with silver nitrate and minimal with hypertonic saline. We suggest that direct injection of scolicidal agents into the cyst should be avoided particulary in case of biliary communication. If this is to be practiced, hypertonic saline should be preferred as a scolicidal agent. SN - 0894-1939 UR - https://www.unboundmedicine.com/medline/citation/15764499/The_effect_of_scolicidal_agents_on_liver_and_biliary_tree__experimental_study__ L2 - http://www.tandfonline.com/doi/full/10.1080/08941930490524363 DB - PRIME DP - Unbound Medicine ER -