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Detection of early atherosclerosis using the ultrasound parameter of the intima-media thickness of the common carotid artery in families with familial combined hyperlipidemia.

Abstract

AIM

The aim of the present study was to quantify intima-media thickness (IMT) of the common carotid artery (CCA) in clinically asymptomatic members of familial combined hyperlipidemia (FCHL) families and to evaluate its association with lipids, apoproteins, blood pressure, surrogate markers of insulin resistance, fibrinogen and hs-CRP.

METHODS

The group under study consisted of 82 individuals from 29 FCHL families (47 hyperlipidemic [HL] and 35 normolipidemic [NL]). They were compared with the age and sex adjusted control groups of healthy subjects (HL-c, n=20 and NL-c, n=20). IMT was measured by ultrasound at a far wall of both common carotid arteries.

RESULTS

Hyperlipidemic subjects had increased IMT compared with healthy controls (0.695+/-0.118 vs 0.599+/-0.074 mm), with an age and sex corrected difference of 86 mm (p<0.001). No difference in IMT was recorded in NL FCHL members in comparison with their healthy controls. In HL subjects, significantly positive univariate correlations were observed between IMT and age, total cholesterol, LDL-cholesterol, non-HDL-cholesterol, apolipoprotein B, SBP, DBP, BMI, waist, fasting glycemia, C-peptide and proinsulin, whereas in NL subjects IMT correlated only with age. Multivariate regression analysis in FCHL subjects (HL+NL) revealed that age (p<0.001), sex (p<0.001), non-HDL-cholesterol (p<0.01) and BMI (p<0.05) were significant and independent predictors of IMT.

CONCLUSIONS

The increase of IMT CCA in hyperlipidemic still clinically asymptomatic FCHL subjects corresponds to acceleration of the clinically ''silent'' atherosclerosis by about 8-14 years and is in agreement with their increased risk of atherosclerosis.

Authors+Show Affiliations

,

3rd Clinic of Internal Medicine, University Hospital and Medical Faculty of Palacky University, Olomouc, Czech Republic. milan.halenka@fnol.cz

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Source

MeSH

Adult
Age Factors
Apolipoproteins B
Biomarkers
Blood Pressure
C-Reactive Protein
Carotid Artery Diseases
Carotid Artery, Common
Case-Control Studies
Cholesterol, HDL
Cholesterol, LDL
Female
Fibrinogen
Humans
Hyperlipidemia, Familial Combined
Male
Middle Aged
Myocardial Contraction
Predictive Value of Tests
Risk Factors
Time Factors
Tunica Intima
Tunica Media
Ultrasonography

Pub Type(s)

Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15765037

Citation

Halenka, M, et al. "Detection of Early Atherosclerosis Using the Ultrasound Parameter of the Intima-media Thickness of the Common Carotid Artery in Families With Familial Combined Hyperlipidemia." International Angiology : a Journal of the International Union of Angiology, vol. 23, no. 3, 2004, pp. 230-7.
Halenka M, Vaverkova H, Hutyra M, et al. Detection of early atherosclerosis using the ultrasound parameter of the intima-media thickness of the common carotid artery in families with familial combined hyperlipidemia. Int Angiol. 2004;23(3):230-7.
Halenka, M., Vaverkova, H., Hutyra, M., Karasek, D., Slavik, L., Novotny, D., & Krskova, M. (2004). Detection of early atherosclerosis using the ultrasound parameter of the intima-media thickness of the common carotid artery in families with familial combined hyperlipidemia. International Angiology : a Journal of the International Union of Angiology, 23(3), pp. 230-7.
Halenka M, et al. Detection of Early Atherosclerosis Using the Ultrasound Parameter of the Intima-media Thickness of the Common Carotid Artery in Families With Familial Combined Hyperlipidemia. Int Angiol. 2004;23(3):230-7. PubMed PMID: 15765037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of early atherosclerosis using the ultrasound parameter of the intima-media thickness of the common carotid artery in families with familial combined hyperlipidemia. AU - Halenka,M, AU - Vaverkova,H, AU - Hutyra,M, AU - Karasek,D, AU - Slavik,L, AU - Novotny,D, AU - Krskova,M, PY - 2005/3/15/pubmed PY - 2006/9/1/medline PY - 2005/3/15/entrez SP - 230 EP - 7 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 23 IS - 3 N2 - AIM: The aim of the present study was to quantify intima-media thickness (IMT) of the common carotid artery (CCA) in clinically asymptomatic members of familial combined hyperlipidemia (FCHL) families and to evaluate its association with lipids, apoproteins, blood pressure, surrogate markers of insulin resistance, fibrinogen and hs-CRP. METHODS: The group under study consisted of 82 individuals from 29 FCHL families (47 hyperlipidemic [HL] and 35 normolipidemic [NL]). They were compared with the age and sex adjusted control groups of healthy subjects (HL-c, n=20 and NL-c, n=20). IMT was measured by ultrasound at a far wall of both common carotid arteries. RESULTS: Hyperlipidemic subjects had increased IMT compared with healthy controls (0.695+/-0.118 vs 0.599+/-0.074 mm), with an age and sex corrected difference of 86 mm (p<0.001). No difference in IMT was recorded in NL FCHL members in comparison with their healthy controls. In HL subjects, significantly positive univariate correlations were observed between IMT and age, total cholesterol, LDL-cholesterol, non-HDL-cholesterol, apolipoprotein B, SBP, DBP, BMI, waist, fasting glycemia, C-peptide and proinsulin, whereas in NL subjects IMT correlated only with age. Multivariate regression analysis in FCHL subjects (HL+NL) revealed that age (p<0.001), sex (p<0.001), non-HDL-cholesterol (p<0.01) and BMI (p<0.05) were significant and independent predictors of IMT. CONCLUSIONS: The increase of IMT CCA in hyperlipidemic still clinically asymptomatic FCHL subjects corresponds to acceleration of the clinically ''silent'' atherosclerosis by about 8-14 years and is in agreement with their increased risk of atherosclerosis. SN - 0392-9590 UR - https://www.unboundmedicine.com/medline/citation/15765037/Detection_of_early_atherosclerosis_using_the_ultrasound_parameter_of_the_intima_media_thickness_of_the_common_carotid_artery_in_families_with_familial_combined_hyperlipidemia_ L2 - http://www.diseaseinfosearch.org/result/8593 DB - PRIME DP - Unbound Medicine ER -