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Effects of a height and weight adjusted dose of local anaesthetic for spinal anaesthesia for elective Caesarean section.
Anaesthesia. 2005 Apr; 60(4):348-53.A

Abstract

In this prospective, randomised, double-blind study, we compared the effects of two dosage regimens. Pregnant patients at term were randomly assigned to two groups to be given diamorphine 0.4 mg in hyperbaric bupivacaine 0.5% 2.4 ml or diamorphine 0.4 mg in a volume of hyperbaric bupivacaine 0.5% adjusted according to the patient's height and weight. Adequate anaesthesia was provided in all patients in both groups. The onset of the sensory block for cold and pinprick was faster with the fixed dose regimen (p = 0.01). There were more spinal blocks to above the first thoracic dermatome in the fixed dose group (17.1% vs. 2.2%, p = 0.022). Hypotension occurred in 71.7% vs. 50.0% of patients in the fixed dose and adjusted dose groups respectively (p = 0.035). In the fixed dose group, more patients required ephedrine to treat hypotension (79.5% vs. 56.8%, p = 0.022) and a larger median dose was administered (9 mg vs. 6 mg, p = 0.042). The decrease in mean (SD) arterial pressure was less in the adjusted group (35.0 (16.4) mmHg vs. 28.0 (13.5) mmHg, p = 0.036).

Authors+Show Affiliations

University of Glasgow Department of Anaesthesia, Queen Elizabeth Building, 10 Alexandra Parade, Glasgow G31. jharten@bigfoot.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15766337

Citation

Harten, J M., et al. "Effects of a Height and Weight Adjusted Dose of Local Anaesthetic for Spinal Anaesthesia for Elective Caesarean Section." Anaesthesia, vol. 60, no. 4, 2005, pp. 348-53.
Harten JM, Boyne I, Hannah P, et al. Effects of a height and weight adjusted dose of local anaesthetic for spinal anaesthesia for elective Caesarean section. Anaesthesia. 2005;60(4):348-53.
Harten, J. M., Boyne, I., Hannah, P., Varveris, D., & Brown, A. (2005). Effects of a height and weight adjusted dose of local anaesthetic for spinal anaesthesia for elective Caesarean section. Anaesthesia, 60(4), 348-53.
Harten JM, et al. Effects of a Height and Weight Adjusted Dose of Local Anaesthetic for Spinal Anaesthesia for Elective Caesarean Section. Anaesthesia. 2005;60(4):348-53. PubMed PMID: 15766337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a height and weight adjusted dose of local anaesthetic for spinal anaesthesia for elective Caesarean section. AU - Harten,J M, AU - Boyne,I, AU - Hannah,P, AU - Varveris,D, AU - Brown,A, PY - 2005/3/16/pubmed PY - 2005/4/12/medline PY - 2005/3/16/entrez SP - 348 EP - 53 JF - Anaesthesia JO - Anaesthesia VL - 60 IS - 4 N2 - In this prospective, randomised, double-blind study, we compared the effects of two dosage regimens. Pregnant patients at term were randomly assigned to two groups to be given diamorphine 0.4 mg in hyperbaric bupivacaine 0.5% 2.4 ml or diamorphine 0.4 mg in a volume of hyperbaric bupivacaine 0.5% adjusted according to the patient's height and weight. Adequate anaesthesia was provided in all patients in both groups. The onset of the sensory block for cold and pinprick was faster with the fixed dose regimen (p = 0.01). There were more spinal blocks to above the first thoracic dermatome in the fixed dose group (17.1% vs. 2.2%, p = 0.022). Hypotension occurred in 71.7% vs. 50.0% of patients in the fixed dose and adjusted dose groups respectively (p = 0.035). In the fixed dose group, more patients required ephedrine to treat hypotension (79.5% vs. 56.8%, p = 0.022) and a larger median dose was administered (9 mg vs. 6 mg, p = 0.042). The decrease in mean (SD) arterial pressure was less in the adjusted group (35.0 (16.4) mmHg vs. 28.0 (13.5) mmHg, p = 0.036). SN - 0003-2409 UR - https://www.unboundmedicine.com/medline/citation/15766337/Effects_of_a_height_and_weight_adjusted_dose_of_local_anaesthetic_for_spinal_anaesthesia_for_elective_Caesarean_section_ L2 - https://doi.org/10.1111/j.1365-2044.2005.04113.x DB - PRIME DP - Unbound Medicine ER -