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Nitric oxide inhibitor altitude-dependently elevates pulmonary arterial pressure in high-altitude adapted yaks.
Respir Physiol Neurobiol. 2005 Apr 15; 146(2-3):225-30.RP

Abstract

We studied the effect of N(w)-nitro-L-arginine (NLA) on yak pulmonary vascular tone in a climatic (hypobaric/hyperbaric adjusted) chamber. Five young male yaks that had been born and reared at an altitude greater than 3800 m a.s.l. were used. After measuring control values, 20 mg/kg of NLA was administered via the jugular vein to each animal, and pulmonary hemodynamics and blood gases were repeatedly measured at simulated altitudes of 0, 2260 and 4500 m. The mean PaO2 decreased in an altitude-dependent manner, whereas there was no change in mean pulmonary arterial pressure (mPAP) or mean cardiac output (mCO). NLA significantly increased mPAP, and mean pulmonary vascular resistance (mPVR), and decreased CO at each tested altitude, and greater increases in mPAP and mPVR by NLA were observed at the higher elevations. We conclude that augmented endogenous NO production, especially at higher altitudes, accounts for the low pulmonary vascular tone observed in high-altitude adapted yaks.

Authors+Show Affiliations

Department of Fundamental Nursing, Faculty of Medicine, University of Fukui, Matsuoka-Cho, Fukui 910-1193, Japan. takeshi@fmsrsa.fukui-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15766910

Citation

Ishizaki, Takeshi, et al. "Nitric Oxide Inhibitor Altitude-dependently Elevates Pulmonary Arterial Pressure in High-altitude Adapted Yaks." Respiratory Physiology & Neurobiology, vol. 146, no. 2-3, 2005, pp. 225-30.
Ishizaki T, Koizumi T, Ruan Z, et al. Nitric oxide inhibitor altitude-dependently elevates pulmonary arterial pressure in high-altitude adapted yaks. Respir Physiol Neurobiol. 2005;146(2-3):225-30.
Ishizaki, T., Koizumi, T., Ruan, Z., Wang, Z., Chen, Q., & Sakai, A. (2005). Nitric oxide inhibitor altitude-dependently elevates pulmonary arterial pressure in high-altitude adapted yaks. Respiratory Physiology & Neurobiology, 146(2-3), 225-30.
Ishizaki T, et al. Nitric Oxide Inhibitor Altitude-dependently Elevates Pulmonary Arterial Pressure in High-altitude Adapted Yaks. Respir Physiol Neurobiol. 2005 Apr 15;146(2-3):225-30. PubMed PMID: 15766910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nitric oxide inhibitor altitude-dependently elevates pulmonary arterial pressure in high-altitude adapted yaks. AU - Ishizaki,Takeshi, AU - Koizumi,Tomonori, AU - Ruan,Zonghai, AU - Wang,Zhangang, AU - Chen,Qiuhong, AU - Sakai,Akio, PY - 2004/09/10/received PY - 2004/12/02/revised PY - 2004/12/04/accepted PY - 2005/3/16/pubmed PY - 2005/5/21/medline PY - 2005/3/16/entrez SP - 225 EP - 30 JF - Respiratory physiology & neurobiology JO - Respir Physiol Neurobiol VL - 146 IS - 2-3 N2 - We studied the effect of N(w)-nitro-L-arginine (NLA) on yak pulmonary vascular tone in a climatic (hypobaric/hyperbaric adjusted) chamber. Five young male yaks that had been born and reared at an altitude greater than 3800 m a.s.l. were used. After measuring control values, 20 mg/kg of NLA was administered via the jugular vein to each animal, and pulmonary hemodynamics and blood gases were repeatedly measured at simulated altitudes of 0, 2260 and 4500 m. The mean PaO2 decreased in an altitude-dependent manner, whereas there was no change in mean pulmonary arterial pressure (mPAP) or mean cardiac output (mCO). NLA significantly increased mPAP, and mean pulmonary vascular resistance (mPVR), and decreased CO at each tested altitude, and greater increases in mPAP and mPVR by NLA were observed at the higher elevations. We conclude that augmented endogenous NO production, especially at higher altitudes, accounts for the low pulmonary vascular tone observed in high-altitude adapted yaks. SN - 1569-9048 UR - https://www.unboundmedicine.com/medline/citation/15766910/Nitric_oxide_inhibitor_altitude_dependently_elevates_pulmonary_arterial_pressure_in_high_altitude_adapted_yaks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1569-9048(04)00331-3 DB - PRIME DP - Unbound Medicine ER -