Tags

Type your tag names separated by a space and hit enter

Effect of bag-in-the-lens implantation on posterior capsule opacification in human donor eyes and rabbit eyes.
J Cataract Refract Surg. 2005 Feb; 31(2):398-405.JC

Abstract

PURPOSE

To evaluate bag-in-the-lens implantation by studying the feasibility of implanting a new type of intraocular lens (IOL) and the occurrence of posterior capsule opacification (PCO) in human postmortem eyes and in eyes of living rabbits.

SETTING

Department of Ophthalmology, University of Antwerp, Belgium, and Netherlands Research Institute of Amsterdam, Amsterdam, The Netherlands.

METHODS

The IOL was implanted in 10 postmortem human donor eyes (in vitro study) and in 17 eyes of 10 rabbits (in vivo study). The postmortem capsular bags were cultured for 4 to 6 weeks, and the rabbits were killed 1 to 5 months after implantation. All capsular bags with the bag-in-the-lens were examined by light microscopy and scanning electron microscopy.

RESULTS

The IOL design was highly effective in restricting lens epithelial cell (LEC) proliferation in the remaining lens bag in human donor eyes and in rabbit eyes. In eyes in which the capsules were not positioned well within the groove of the IOL, LEC proliferation and PCO occurred.

CONCLUSION

Bag-in-the-lens implantation was highly effective in preventing PCO in vitro and in vivo provided the anterior and posterior capsules were secured properly in the peripheral groove of the IOL.

Authors+Show Affiliations

Department of Ophthalmology, University of Antwerp, Edegem, Belgium. veva.de.groot@uza.beNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15767165

Citation

De Groot, Veva, et al. "Effect of Bag-in-the-lens Implantation On Posterior Capsule Opacification in Human Donor Eyes and Rabbit Eyes." Journal of Cataract and Refractive Surgery, vol. 31, no. 2, 2005, pp. 398-405.
De Groot V, Tassignon MJ, Vrensen GF. Effect of bag-in-the-lens implantation on posterior capsule opacification in human donor eyes and rabbit eyes. J Cataract Refract Surg. 2005;31(2):398-405.
De Groot, V., Tassignon, M. J., & Vrensen, G. F. (2005). Effect of bag-in-the-lens implantation on posterior capsule opacification in human donor eyes and rabbit eyes. Journal of Cataract and Refractive Surgery, 31(2), 398-405.
De Groot V, Tassignon MJ, Vrensen GF. Effect of Bag-in-the-lens Implantation On Posterior Capsule Opacification in Human Donor Eyes and Rabbit Eyes. J Cataract Refract Surg. 2005;31(2):398-405. PubMed PMID: 15767165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of bag-in-the-lens implantation on posterior capsule opacification in human donor eyes and rabbit eyes. AU - De Groot,Veva, AU - Tassignon,Marie-José B R, AU - Vrensen,Gijs F J M, PY - 2004/04/30/accepted PY - 2005/3/16/pubmed PY - 2005/4/27/medline PY - 2005/3/16/entrez SP - 398 EP - 405 JF - Journal of cataract and refractive surgery JO - J Cataract Refract Surg VL - 31 IS - 2 N2 - PURPOSE: To evaluate bag-in-the-lens implantation by studying the feasibility of implanting a new type of intraocular lens (IOL) and the occurrence of posterior capsule opacification (PCO) in human postmortem eyes and in eyes of living rabbits. SETTING: Department of Ophthalmology, University of Antwerp, Belgium, and Netherlands Research Institute of Amsterdam, Amsterdam, The Netherlands. METHODS: The IOL was implanted in 10 postmortem human donor eyes (in vitro study) and in 17 eyes of 10 rabbits (in vivo study). The postmortem capsular bags were cultured for 4 to 6 weeks, and the rabbits were killed 1 to 5 months after implantation. All capsular bags with the bag-in-the-lens were examined by light microscopy and scanning electron microscopy. RESULTS: The IOL design was highly effective in restricting lens epithelial cell (LEC) proliferation in the remaining lens bag in human donor eyes and in rabbit eyes. In eyes in which the capsules were not positioned well within the groove of the IOL, LEC proliferation and PCO occurred. CONCLUSION: Bag-in-the-lens implantation was highly effective in preventing PCO in vitro and in vivo provided the anterior and posterior capsules were secured properly in the peripheral groove of the IOL. SN - 0886-3350 UR - https://www.unboundmedicine.com/medline/citation/15767165/Effect_of_bag_in_the_lens_implantation_on_posterior_capsule_opacification_in_human_donor_eyes_and_rabbit_eyes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0886-3350(04)00693-5 DB - PRIME DP - Unbound Medicine ER -