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Individual growth curve analysis of APOE epsilon 4-associated cognitive decline in Alzheimer disease.
Arch Neurol 2005; 62(3):454-9AN

Abstract

BACKGROUND

The apolipoprotein E epsilon4 (APOE epsilon4) allele is associated with an increased risk of developing Alzheimer disease (AD). However, findings regarding an association between the APOE epsilon4 allele and the rate of decline in AD have been mixed.

OBJECTIVE

To examine the relationship between the APOE epsilon4 allele and the rate of cognitive and functional decline in AD using individual growth curve analyses.

DESIGN

Longitudinal cohort study.

SETTING

Alzheimer Disease Research Center at Baylor College of Medicine.

PATIENTS

A total of 189 patients meeting NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association) criteria for probable AD at baseline who underwent annual follow-up evaluations for at least 2 years.

MAIN OUTCOME MEASURES

Individual growth curve parameters derived from baseline and follow-up performance on global and specific measures of cognitive and functional abilities.

RESULTS

Patients with 2 APOE epsilon4 alleles exhibited a slower rate of decline on measures of global cognitive functioning and functional abilities. No significant association was detected between the APOE epsilon4 allele and the rate of decline on measures of specific cognitive functions.

CONCLUSIONS

Although the APOE epsilon4 allele is associated with an increased risk of developing AD, it seems that having 2 APOE epsilon4 alleles is associated with a slower clinical course. These findings are consistent with hypotheses that the biological processes contributing to the onset of AD are different from those involved in determining its clinical course.

Authors+Show Affiliations

Department of Psychology, University of Houston, Houston, Tex, USA. HoytB@NJC.org

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15767511

Citation

Hoyt, Brian D., et al. "Individual Growth Curve Analysis of APOE Epsilon 4-associated Cognitive Decline in Alzheimer Disease." Archives of Neurology, vol. 62, no. 3, 2005, pp. 454-9.
Hoyt BD, Massman PJ, Schatschneider C, et al. Individual growth curve analysis of APOE epsilon 4-associated cognitive decline in Alzheimer disease. Arch Neurol. 2005;62(3):454-9.
Hoyt, B. D., Massman, P. J., Schatschneider, C., Cooke, N., & Doody, R. S. (2005). Individual growth curve analysis of APOE epsilon 4-associated cognitive decline in Alzheimer disease. Archives of Neurology, 62(3), pp. 454-9.
Hoyt BD, et al. Individual Growth Curve Analysis of APOE Epsilon 4-associated Cognitive Decline in Alzheimer Disease. Arch Neurol. 2005;62(3):454-9. PubMed PMID: 15767511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Individual growth curve analysis of APOE epsilon 4-associated cognitive decline in Alzheimer disease. AU - Hoyt,Brian D, AU - Massman,Paul J, AU - Schatschneider,Christopher, AU - Cooke,Norma, AU - Doody,Rachelle S, PY - 2005/3/16/pubmed PY - 2005/4/6/medline PY - 2005/3/16/entrez SP - 454 EP - 9 JF - Archives of neurology JO - Arch. Neurol. VL - 62 IS - 3 N2 - BACKGROUND: The apolipoprotein E epsilon4 (APOE epsilon4) allele is associated with an increased risk of developing Alzheimer disease (AD). However, findings regarding an association between the APOE epsilon4 allele and the rate of decline in AD have been mixed. OBJECTIVE: To examine the relationship between the APOE epsilon4 allele and the rate of cognitive and functional decline in AD using individual growth curve analyses. DESIGN: Longitudinal cohort study. SETTING: Alzheimer Disease Research Center at Baylor College of Medicine. PATIENTS: A total of 189 patients meeting NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association) criteria for probable AD at baseline who underwent annual follow-up evaluations for at least 2 years. MAIN OUTCOME MEASURES: Individual growth curve parameters derived from baseline and follow-up performance on global and specific measures of cognitive and functional abilities. RESULTS: Patients with 2 APOE epsilon4 alleles exhibited a slower rate of decline on measures of global cognitive functioning and functional abilities. No significant association was detected between the APOE epsilon4 allele and the rate of decline on measures of specific cognitive functions. CONCLUSIONS: Although the APOE epsilon4 allele is associated with an increased risk of developing AD, it seems that having 2 APOE epsilon4 alleles is associated with a slower clinical course. These findings are consistent with hypotheses that the biological processes contributing to the onset of AD are different from those involved in determining its clinical course. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/15767511/Individual_growth_curve_analysis_of_APOE_epsilon_4_associated_cognitive_decline_in_Alzheimer_disease_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.62.3.454 DB - PRIME DP - Unbound Medicine ER -