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JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4494-9.PN

Abstract

DAF-16/forkhead transcription factor, the downstream target of the insulin-like signaling in Caenorhabditis elegans, is indispensable for both lifespan regulation and stress resistance. Here, we demonstrate that c-Jun N-terminal kinase (JNK) is a positive regulator of DAF-16 in both processes. Our genetic analysis suggests that the JNK pathway acts in parallel with the insulin-like signaling pathway to regulate lifespan and both pathways converge onto DAF-16. We also show that JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus. Our findings define an interaction between two well conserved proteins, JNK-1 and DAF-16, and provide a mechanism by which JNK regulates longevity and stress resistance.

Authors+Show Affiliations

Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15767565

Citation

Oh, Seung Wook, et al. "JNK Regulates Lifespan in Caenorhabditis Elegans By Modulating Nuclear Translocation of Forkhead Transcription Factor/DAF-16." Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 12, 2005, pp. 4494-9.
Oh SW, Mukhopadhyay A, Svrzikapa N, et al. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci USA. 2005;102(12):4494-9.
Oh, S. W., Mukhopadhyay, A., Svrzikapa, N., Jiang, F., Davis, R. J., & Tissenbaum, H. A. (2005). JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proceedings of the National Academy of Sciences of the United States of America, 102(12), 4494-9.
Oh SW, et al. JNK Regulates Lifespan in Caenorhabditis Elegans By Modulating Nuclear Translocation of Forkhead Transcription Factor/DAF-16. Proc Natl Acad Sci USA. 2005 Mar 22;102(12):4494-9. PubMed PMID: 15767565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. AU - Oh,Seung Wook, AU - Mukhopadhyay,Arnab, AU - Svrzikapa,Nenad, AU - Jiang,Feng, AU - Davis,Roger J, AU - Tissenbaum,Heidi A, Y1 - 2005/03/14/ PY - 2005/3/16/pubmed PY - 2005/5/4/medline PY - 2005/3/16/entrez SP - 4494 EP - 9 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc. Natl. Acad. Sci. U.S.A. VL - 102 IS - 12 N2 - DAF-16/forkhead transcription factor, the downstream target of the insulin-like signaling in Caenorhabditis elegans, is indispensable for both lifespan regulation and stress resistance. Here, we demonstrate that c-Jun N-terminal kinase (JNK) is a positive regulator of DAF-16 in both processes. Our genetic analysis suggests that the JNK pathway acts in parallel with the insulin-like signaling pathway to regulate lifespan and both pathways converge onto DAF-16. We also show that JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus. Our findings define an interaction between two well conserved proteins, JNK-1 and DAF-16, and provide a mechanism by which JNK regulates longevity and stress resistance. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/15767565/JNK_regulates_lifespan_in_Caenorhabditis_elegans_by_modulating_nuclear_translocation_of_forkhead_transcription_factor/DAF_16_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=15767565 DB - PRIME DP - Unbound Medicine ER -