Tags

Type your tag names separated by a space and hit enter

Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA).
Circulation. 2005 Mar 15; 111(10):1313-20.Circ

Abstract

BACKGROUND

There is substantial evidence that coronary calcification, a marker for the presence and quantity of coronary atherosclerosis, is higher in US whites than blacks; however, there have been no large population-based studies comparing coronary calcification among US ethnic groups.

METHODS AND RESULTS

Using computed tomography, we measured coronary calcification in 6814 white, black, Hispanic, and Chinese men and women aged 45 to 84 years with no clinical cardiovascular disease who participated in the Multi-Ethnic Study of Atherosclerosis (MESA). The prevalence of coronary calcification (Agatston score >0) in these 4 ethnic groups was 70.4%, 52.1%, 56.5%, and 59.2%, respectively, in men (P<0.001) and 44.6%, 36.5%, 34.9%, and 41.9%, respectively, (P<0.001) in women. After adjustment for age, education, lipids, body mass index, smoking, diabetes, hypertension, treatment for hypercholesterolemia, gender, and scanning center, compared with whites, the relative risks for having coronary calcification were 0.78 (95% CI 0.74 to 0.82) in blacks, 0.85 (95% CI 0.79 to 0.91) in Hispanics, and 0.92 (95% CI 0.85 to 0.99) in Chinese. After similar adjustments, the amount of coronary calcification among those with an Agatston score >0 was greatest among whites, followed by Chinese (77% that of whites; 95% CI 62% to 96%), Hispanics (74%; 95% CI 61% to 90%), and blacks (69%; 95% CI 59% to 80%).

CONCLUSIONS

We observed ethnic differences in the presence and quantity of coronary calcification that were not explained by coronary risk factors. Identification of the mechanism underlying these differences would further our understanding of the pathophysiology of coronary calcification and its clinical significance. Data on the predictive value of coronary calcium in different ethnic groups are needed.

Authors+Show Affiliations

Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md, USA. bildd@nhlbi.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15769774

Citation

Bild, Diane E., et al. "Ethnic Differences in Coronary Calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)." Circulation, vol. 111, no. 10, 2005, pp. 1313-20.
Bild DE, Detrano R, Peterson D, et al. Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2005;111(10):1313-20.
Bild, D. E., Detrano, R., Peterson, D., Guerci, A., Liu, K., Shahar, E., Ouyang, P., Jackson, S., & Saad, M. F. (2005). Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation, 111(10), 1313-20.
Bild DE, et al. Ethnic Differences in Coronary Calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2005 Mar 15;111(10):1313-20. PubMed PMID: 15769774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). AU - Bild,Diane E, AU - Detrano,Robert, AU - Peterson,Do, AU - Guerci,Alan, AU - Liu,Kiang, AU - Shahar,Eyal, AU - Ouyang,Pamela, AU - Jackson,Sharon, AU - Saad,Mohammed F, PY - 2005/3/17/pubmed PY - 2005/10/12/medline PY - 2005/3/17/entrez SP - 1313 EP - 20 JF - Circulation JO - Circulation VL - 111 IS - 10 N2 - BACKGROUND: There is substantial evidence that coronary calcification, a marker for the presence and quantity of coronary atherosclerosis, is higher in US whites than blacks; however, there have been no large population-based studies comparing coronary calcification among US ethnic groups. METHODS AND RESULTS: Using computed tomography, we measured coronary calcification in 6814 white, black, Hispanic, and Chinese men and women aged 45 to 84 years with no clinical cardiovascular disease who participated in the Multi-Ethnic Study of Atherosclerosis (MESA). The prevalence of coronary calcification (Agatston score >0) in these 4 ethnic groups was 70.4%, 52.1%, 56.5%, and 59.2%, respectively, in men (P<0.001) and 44.6%, 36.5%, 34.9%, and 41.9%, respectively, (P<0.001) in women. After adjustment for age, education, lipids, body mass index, smoking, diabetes, hypertension, treatment for hypercholesterolemia, gender, and scanning center, compared with whites, the relative risks for having coronary calcification were 0.78 (95% CI 0.74 to 0.82) in blacks, 0.85 (95% CI 0.79 to 0.91) in Hispanics, and 0.92 (95% CI 0.85 to 0.99) in Chinese. After similar adjustments, the amount of coronary calcification among those with an Agatston score >0 was greatest among whites, followed by Chinese (77% that of whites; 95% CI 62% to 96%), Hispanics (74%; 95% CI 61% to 90%), and blacks (69%; 95% CI 59% to 80%). CONCLUSIONS: We observed ethnic differences in the presence and quantity of coronary calcification that were not explained by coronary risk factors. Identification of the mechanism underlying these differences would further our understanding of the pathophysiology of coronary calcification and its clinical significance. Data on the predictive value of coronary calcium in different ethnic groups are needed. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/15769774/Ethnic_differences_in_coronary_calcification:_the_Multi_Ethnic_Study_of_Atherosclerosis__MESA__ L2 - http://www.ahajournals.org/doi/full/10.1161/01.CIR.0000157730.94423.4B?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -