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Leptin levels in obese women with and without type 2 diabetes mellitus.
Mediators Inflamm. 2004 Dec; 13(5-6):321-5.MI

Abstract

INTRODUCTION

The role of leptin has been more clear in the endocrinology area after the discovery of its secretion from the adipose tissue. The aim of the study is to investigate the leptin levels in obese women in whom type 2 diabetes mellitus were present or absent.

MATERIALS AND METHODS

Thirty-five obese women with type 2 diabetes mellitus (group 1) and 34 obese women without type 2 diabetes mellitus (group 2) were enrolled in the study. In both groups the body mass index (BMI), waist circumference, and waist-to-hip ratio were measured. Leptin, HbA1c, creatinine and the lipid profile were assessed.

RESULTS

Leptin was found to be statistically significantly lower in group 1 than in group 2 (40.22 +/- 17.77 ng/ml versus 50.12 +/- 15.51 ng/ml, respectively; p = 0.019). It was well correlated with BMI in group 1 (r = 0.60, p = 0.0001). In group 1 also, correlation of leptin was moderate with creatinine and high-density lipoprotein-cholesterol (r = 0.36, p = 0.037 versus r = 0.37, p = 0.027, respectively), whereas triglyceride had a negative correlation (r = -0.34, p = 0.046). In group 2, the only significant correlation with leptin was BMI (r = 0.41, p = 0.02). Leptin was also significantly lower in 17 subjects with poorly controlled diabetes mellitus than in 18 well-controlled diabetics (33.54 +/- 15.82 ng/ml versus 44.61 +/- 17.54 ng/ml, respectively; p = 0.038).

CONCLUSION

Since leptin is lower in obese women with diabetes than without diabetes and additionally it is even lower in the poorly controlled diabetes subgroup, we think that further studies a rerequired to make clear the issue for lower leptin levels, whether it is a reason or an outcome.

Authors+Show Affiliations

Department of Internal Medicine, Kahramanmaras Sutcu Imam University, Faculty of Medicine, 46050 Kahramanmaras, Turkey. akif_buyukbese@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15770047

Citation

Buyukbese, Mehmet Akif, et al. "Leptin Levels in Obese Women With and Without Type 2 Diabetes Mellitus." Mediators of Inflammation, vol. 13, no. 5-6, 2004, pp. 321-5.
Buyukbese MA, Cetinkaya A, Kocabas R, et al. Leptin levels in obese women with and without type 2 diabetes mellitus. Mediators Inflamm. 2004;13(5-6):321-5.
Buyukbese, M. A., Cetinkaya, A., Kocabas, R., Guven, A., & Tarakcioglu, M. (2004). Leptin levels in obese women with and without type 2 diabetes mellitus. Mediators of Inflammation, 13(5-6), 321-5.
Buyukbese MA, et al. Leptin Levels in Obese Women With and Without Type 2 Diabetes Mellitus. Mediators Inflamm. 2004;13(5-6):321-5. PubMed PMID: 15770047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptin levels in obese women with and without type 2 diabetes mellitus. AU - Buyukbese,Mehmet Akif, AU - Cetinkaya,Ali, AU - Kocabas,Ramazan, AU - Guven,Aytekin, AU - Tarakcioglu,Mehmet, PY - 2005/3/17/pubmed PY - 2005/5/19/medline PY - 2005/3/17/entrez SP - 321 EP - 5 JF - Mediators of inflammation JO - Mediators Inflamm VL - 13 IS - 5-6 N2 - INTRODUCTION: The role of leptin has been more clear in the endocrinology area after the discovery of its secretion from the adipose tissue. The aim of the study is to investigate the leptin levels in obese women in whom type 2 diabetes mellitus were present or absent. MATERIALS AND METHODS: Thirty-five obese women with type 2 diabetes mellitus (group 1) and 34 obese women without type 2 diabetes mellitus (group 2) were enrolled in the study. In both groups the body mass index (BMI), waist circumference, and waist-to-hip ratio were measured. Leptin, HbA1c, creatinine and the lipid profile were assessed. RESULTS: Leptin was found to be statistically significantly lower in group 1 than in group 2 (40.22 +/- 17.77 ng/ml versus 50.12 +/- 15.51 ng/ml, respectively; p = 0.019). It was well correlated with BMI in group 1 (r = 0.60, p = 0.0001). In group 1 also, correlation of leptin was moderate with creatinine and high-density lipoprotein-cholesterol (r = 0.36, p = 0.037 versus r = 0.37, p = 0.027, respectively), whereas triglyceride had a negative correlation (r = -0.34, p = 0.046). In group 2, the only significant correlation with leptin was BMI (r = 0.41, p = 0.02). Leptin was also significantly lower in 17 subjects with poorly controlled diabetes mellitus than in 18 well-controlled diabetics (33.54 +/- 15.82 ng/ml versus 44.61 +/- 17.54 ng/ml, respectively; p = 0.038). CONCLUSION: Since leptin is lower in obese women with diabetes than without diabetes and additionally it is even lower in the poorly controlled diabetes subgroup, we think that further studies a rerequired to make clear the issue for lower leptin levels, whether it is a reason or an outcome. SN - 0962-9351 UR - https://www.unboundmedicine.com/medline/citation/15770047/Leptin_levels_in_obese_women_with_and_without_type_2_diabetes_mellitus_ L2 - https://doi.org/10.1080/09629350400008828 DB - PRIME DP - Unbound Medicine ER -