Tags

Type your tag names separated by a space and hit enter

Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol.
Alcohol Clin Exp Res. 2005 Mar; 29(3):358-66.AC

Abstract

BACKGROUND

The ventral tegmental area (VTA) is involved in regulating ethanol drinking, and the posterior VTA seems to be a neuroanatomical substrate that mediates the reinforcing effects of ethanol in ethanol-naive Wistar and ethanol-naive alcohol-preferring (P) rats. The objective of this study was to test the hypothesis that chronic ethanol drinking increases the sensitivity of the posterior VTA to the reinforcing effects of ethanol.

METHODS

Two groups of female P rats (one given water as its sole source of fluid and the other given 24-hr free-choice access to 15% ethanol and water for at least 8 weeks) were stereotaxically implanted with guide cannulae aimed at the posterior VTA. One week after surgery, rats were placed in standard two-lever (active and inactive) operant chambers and connected to the microinfusion system. Depression of the active lever produced the infusion of 100 nl of artificial cerebrospinal fluid (CSF) or ethanol. The ethanol-naive and chronic ethanol-drinking groups were assigned to subgroups to receive artificial CSF or 25, 50, 75, or 125 mg/dl of ethanol (n = 6-9/dose/group) to self-infuse (FR1 schedule) during the 4-hr sessions given every other day.

RESULTS

Compared with the infusions of artificial CSF, the control group reliably (p < 0.05) self-infused 75 and 125 mg/dl of ethanol but not the lower concentrations. The ethanol-drinking group had significantly (p < 0.05) higher self-infusions of 50, 75, and 125 mg/dl of ethanol than artificial CSF during the four acquisition sessions; the number of infusions of all three doses was higher in the ethanol-drinking group than in the ethanol-naive group. Both groups decreased responding on the active lever when artificial CSF was substituted for ethanol, and both groups demonstrated robust reinstatement of responding on the active lever when ethanol was restored.

CONCLUSIONS

Chronic ethanol drinking by P rats increased the sensitivity of the posterior VTA to the reinforcing effects of ethanol.

Authors+Show Affiliations

Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indiana University, 791 Union Drive, Indianapolis, IN 46202, USA. zrodd@iupui.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15770111

Citation

Rodd, Zachary A., et al. "Chronic Ethanol Drinking By Alcohol-preferring Rats Increases the Sensitivity of the Posterior Ventral Tegmental Area to the Reinforcing Effects of Ethanol." Alcoholism, Clinical and Experimental Research, vol. 29, no. 3, 2005, pp. 358-66.
Rodd ZA, Bell RL, McQueen VK, et al. Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol. Alcohol Clin Exp Res. 2005;29(3):358-66.
Rodd, Z. A., Bell, R. L., McQueen, V. K., Davids, M. R., Hsu, C. C., Murphy, J. M., Li, T. K., Lumeng, L., & McBride, W. J. (2005). Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol. Alcoholism, Clinical and Experimental Research, 29(3), 358-66.
Rodd ZA, et al. Chronic Ethanol Drinking By Alcohol-preferring Rats Increases the Sensitivity of the Posterior Ventral Tegmental Area to the Reinforcing Effects of Ethanol. Alcohol Clin Exp Res. 2005;29(3):358-66. PubMed PMID: 15770111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol. AU - Rodd,Zachary A, AU - Bell,Richard L, AU - McQueen,Victoria K, AU - Davids,Michelle R, AU - Hsu,Cathleen C, AU - Murphy,James M, AU - Li,Ting-Kai, AU - Lumeng,Lawrence, AU - McBride,William J, PY - 2005/3/17/pubmed PY - 2005/6/28/medline PY - 2005/3/17/entrez SP - 358 EP - 66 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 29 IS - 3 N2 - BACKGROUND: The ventral tegmental area (VTA) is involved in regulating ethanol drinking, and the posterior VTA seems to be a neuroanatomical substrate that mediates the reinforcing effects of ethanol in ethanol-naive Wistar and ethanol-naive alcohol-preferring (P) rats. The objective of this study was to test the hypothesis that chronic ethanol drinking increases the sensitivity of the posterior VTA to the reinforcing effects of ethanol. METHODS: Two groups of female P rats (one given water as its sole source of fluid and the other given 24-hr free-choice access to 15% ethanol and water for at least 8 weeks) were stereotaxically implanted with guide cannulae aimed at the posterior VTA. One week after surgery, rats were placed in standard two-lever (active and inactive) operant chambers and connected to the microinfusion system. Depression of the active lever produced the infusion of 100 nl of artificial cerebrospinal fluid (CSF) or ethanol. The ethanol-naive and chronic ethanol-drinking groups were assigned to subgroups to receive artificial CSF or 25, 50, 75, or 125 mg/dl of ethanol (n = 6-9/dose/group) to self-infuse (FR1 schedule) during the 4-hr sessions given every other day. RESULTS: Compared with the infusions of artificial CSF, the control group reliably (p < 0.05) self-infused 75 and 125 mg/dl of ethanol but not the lower concentrations. The ethanol-drinking group had significantly (p < 0.05) higher self-infusions of 50, 75, and 125 mg/dl of ethanol than artificial CSF during the four acquisition sessions; the number of infusions of all three doses was higher in the ethanol-drinking group than in the ethanol-naive group. Both groups decreased responding on the active lever when artificial CSF was substituted for ethanol, and both groups demonstrated robust reinstatement of responding on the active lever when ethanol was restored. CONCLUSIONS: Chronic ethanol drinking by P rats increased the sensitivity of the posterior VTA to the reinforcing effects of ethanol. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/15770111/Chronic_ethanol_drinking_by_alcohol_preferring_rats_increases_the_sensitivity_of_the_posterior_ventral_tegmental_area_to_the_reinforcing_effects_of_ethanol_ DB - PRIME DP - Unbound Medicine ER -