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Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States.
Hepatology. 2005 May; 41(5):1029-36.Hep

Abstract

Although cirrhosis is a known risk factor for gallstones, little is known about gallbladder disease (GBD) in individuals with hepatitis C virus (HCV) infection. We determined the association between chronic HCV infection and GBD in a representative sample of adults in the United States. Data on HCV infection and GBD were available for 13,465 persons 20 to 74 years of age who participated in the Third National Health and Nutrition Examination Survey. The presence of GBD (gallstones or cholecystectomy) was determined using abdominal ultrasonography, and HCV infection was assessed via a positive HCV antibody test and a positive HCV RNA test. Overall, 1.6% of adults (95% CI, 1.1-2.1) had chronic HCV infection and 12.5% (95% CI, 11.3-13.7) had GBD. After adjusting for potential confounding variables, the odds of gallstones (OR = 3.20; 95% CI, 1.08-9.45) and cholecystectomy (OR = 4.57; 95% CI, 1.57-13.27) among HCV-positive men was significantly higher compared with HCV-negative men. In contrast, the adjusted odds of gallstones (OR = 2.55; 95% CI, 0.58-11.25) and cholecystectomy (OR = 0.70; 95% CI, 0.21-2.37) among HCV-positive women was not significantly higher. The odds of GBD increased significantly with the severity of liver disease as assessed via elevated serum bilirubin levels and low levels of serum albumin and platelets. In conclusion, chronic HCV infection was strongly associated with GBD among men but not women in the United States, and GBD was more common in adults with severe liver disease.

Authors+Show Affiliations

Division of Gastroenterology, VA New York Harbor Healthcare System and NYU School of Medicine, New York, NY 10010, USA. edmund.bini@med.va.govNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15770666

Citation

Bini, Edmund J., and John McGready. "Prevalence of Gallbladder Disease Among Persons With Hepatitis C Virus Infection in the United States." Hepatology (Baltimore, Md.), vol. 41, no. 5, 2005, pp. 1029-36.
Bini EJ, McGready J. Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States. Hepatology. 2005;41(5):1029-36.
Bini, E. J., & McGready, J. (2005). Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States. Hepatology (Baltimore, Md.), 41(5), 1029-36.
Bini EJ, McGready J. Prevalence of Gallbladder Disease Among Persons With Hepatitis C Virus Infection in the United States. Hepatology. 2005;41(5):1029-36. PubMed PMID: 15770666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States. AU - Bini,Edmund J, AU - McGready,John, PY - 2005/3/17/pubmed PY - 2005/6/2/medline PY - 2005/3/17/entrez SP - 1029 EP - 36 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 41 IS - 5 N2 - Although cirrhosis is a known risk factor for gallstones, little is known about gallbladder disease (GBD) in individuals with hepatitis C virus (HCV) infection. We determined the association between chronic HCV infection and GBD in a representative sample of adults in the United States. Data on HCV infection and GBD were available for 13,465 persons 20 to 74 years of age who participated in the Third National Health and Nutrition Examination Survey. The presence of GBD (gallstones or cholecystectomy) was determined using abdominal ultrasonography, and HCV infection was assessed via a positive HCV antibody test and a positive HCV RNA test. Overall, 1.6% of adults (95% CI, 1.1-2.1) had chronic HCV infection and 12.5% (95% CI, 11.3-13.7) had GBD. After adjusting for potential confounding variables, the odds of gallstones (OR = 3.20; 95% CI, 1.08-9.45) and cholecystectomy (OR = 4.57; 95% CI, 1.57-13.27) among HCV-positive men was significantly higher compared with HCV-negative men. In contrast, the adjusted odds of gallstones (OR = 2.55; 95% CI, 0.58-11.25) and cholecystectomy (OR = 0.70; 95% CI, 0.21-2.37) among HCV-positive women was not significantly higher. The odds of GBD increased significantly with the severity of liver disease as assessed via elevated serum bilirubin levels and low levels of serum albumin and platelets. In conclusion, chronic HCV infection was strongly associated with GBD among men but not women in the United States, and GBD was more common in adults with severe liver disease. SN - 0270-9139 UR - https://www.unboundmedicine.com/medline/citation/15770666/Prevalence_of_gallbladder_disease_among_persons_with_hepatitis_C_virus_infection_in_the_United_States_ L2 - https://doi.org/10.1002/hep.20647 DB - PRIME DP - Unbound Medicine ER -