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Cigarette smoking and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort study.
J Obstet Gynaecol Res. 2005 Apr; 31(2):144-51.JO

Abstract

AIM

The many studies into the relation between cigarette smoking and the risk of ovarian cancer have produced inconsistent results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, initiated in 1988.

METHODS

A self-administered questionnaire on smoking habits and other risk factors for cancer was completed by 34 639 Japanese women. After 7.6 years of follow up, 39 cases of ovarian cancer were available for analyses. Cox proportional-hazards models were used to compute relative risks (RR) and to adjust for confounders.

RESULTS

Relative to those who had never smoked, the RR of ovarian cancer were 1.63 (95% confidence interval [CI] = 0.21-12.50) for former smokers and 2.27 (95% CI = 0.85-6.08) for current smokers. Among current smokers, the RR were 1.48 (95% CI = 0.20-10.92), 5.56 (95% CI = 1.68-19.06), and 1.86 (95% CI = 0.25-14.30) among women who smoked <10, 10-19, and at least 20 pack-years ([number of cigarettes smoked per day/20] x number of years subject has smoked), respectively, relative to those who had never smoked. A test for trend was statistically significant (P = 0.044).

CONCLUSIONS

These data indicate that cigarette smoking increases the risk of developing ovarian cancer in the Japanese population.

Authors+Show Affiliations

Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan. ytt-niwa@xg7.so-net.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15771641

Citation

Niwa, Yoshimitsu, et al. "Cigarette Smoking and the Risk of Ovarian Cancer in the Japanese Population: Findings From the Japanese Collaborate Cohort Study." The Journal of Obstetrics and Gynaecology Research, vol. 31, no. 2, 2005, pp. 144-51.
Niwa Y, Wakai K, Suzuki S, et al. Cigarette smoking and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort study. J Obstet Gynaecol Res. 2005;31(2):144-51.
Niwa, Y., Wakai, K., Suzuki, S., Tamakoshi, K., Lin, Y., Yatsuya, H., Kondo, T., Nishio, K., Yamamoto, A., Tokudome, S., Hamajima, N., Toyoshima, H., & Tamakoshi, A. (2005). Cigarette smoking and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort study. The Journal of Obstetrics and Gynaecology Research, 31(2), 144-51.
Niwa Y, et al. Cigarette Smoking and the Risk of Ovarian Cancer in the Japanese Population: Findings From the Japanese Collaborate Cohort Study. J Obstet Gynaecol Res. 2005;31(2):144-51. PubMed PMID: 15771641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort study. AU - Niwa,Yoshimitsu, AU - Wakai,Kenji, AU - Suzuki,Sadao, AU - Tamakoshi,Koji, AU - Lin,Yingsong, AU - Yatsuya,Hiroshi, AU - Kondo,Takaaki, AU - Nishio,Kazuko, AU - Yamamoto,Akio, AU - Tokudome,Shinkan, AU - Hamajima,Nobuyuki, AU - Toyoshima,Hideaki, AU - Tamakoshi,Akiko, AU - ,, PY - 2005/3/18/pubmed PY - 2005/8/6/medline PY - 2005/3/18/entrez SP - 144 EP - 51 JF - The journal of obstetrics and gynaecology research JO - J. Obstet. Gynaecol. Res. VL - 31 IS - 2 N2 - AIM: The many studies into the relation between cigarette smoking and the risk of ovarian cancer have produced inconsistent results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, initiated in 1988. METHODS: A self-administered questionnaire on smoking habits and other risk factors for cancer was completed by 34 639 Japanese women. After 7.6 years of follow up, 39 cases of ovarian cancer were available for analyses. Cox proportional-hazards models were used to compute relative risks (RR) and to adjust for confounders. RESULTS: Relative to those who had never smoked, the RR of ovarian cancer were 1.63 (95% confidence interval [CI] = 0.21-12.50) for former smokers and 2.27 (95% CI = 0.85-6.08) for current smokers. Among current smokers, the RR were 1.48 (95% CI = 0.20-10.92), 5.56 (95% CI = 1.68-19.06), and 1.86 (95% CI = 0.25-14.30) among women who smoked <10, 10-19, and at least 20 pack-years ([number of cigarettes smoked per day/20] x number of years subject has smoked), respectively, relative to those who had never smoked. A test for trend was statistically significant (P = 0.044). CONCLUSIONS: These data indicate that cigarette smoking increases the risk of developing ovarian cancer in the Japanese population. SN - 1341-8076 UR - https://www.unboundmedicine.com/medline/citation/15771641/Cigarette_smoking_and_the_risk_of_ovarian_cancer_in_the_Japanese_population:_findings_from_the_Japanese_Collaborate_Cohort_study_ L2 - https://doi.org/10.1111/j.1447-0756.2005.00261.x DB - PRIME DP - Unbound Medicine ER -