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Human African trypanosomiasis: clinical presentation and immune response.
Parasite Immunol. 2004 Nov-Dec; 26(11-12):469-76.PI

Abstract

Human African trypanosomiasis or sleeping sickness is caused by infection with two subspecies of the tsetse-fly-vectored haemoflagellate parasite Trypanosoma brucei. Historically, epidemic sleeping sickness has caused massive loss of life, and related animal diseases have had a crucial impact on development in sub-Saharan Africa. After a period of moderately successful control during the mid-part of the 20th century, sleeping sickness incidence is currently rising, and control is hampered by a combination of factors, including civil unrest and the possible development of drug resistance by the parasites. The prevailing view is that the disease is invariably fatal without anti-trypanosomal drug treatment. However, there have also been intriguing reports of wide variations in disease severity as well as evidence of asymptomatic carriers of trypanosomes. These differences in the presentation of the disease will be discussed in the context of our knowledge of the immunology of trypanosomiasis. The impact of dysregulated inflammatory responses in both systemic and CNS pathology will be examined and the potential for host genotype variation in disease severity and control will be discussed.

Authors+Show Affiliations

Zoology Building, School of Biological Sciences, University of Aberdeen, UK. j.sternberg@abdn.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15771682

Citation

Sternberg, J M.. "Human African Trypanosomiasis: Clinical Presentation and Immune Response." Parasite Immunology, vol. 26, no. 11-12, 2004, pp. 469-76.
Sternberg JM. Human African trypanosomiasis: clinical presentation and immune response. Parasite Immunol. 2004;26(11-12):469-76.
Sternberg, J. M. (2004). Human African trypanosomiasis: clinical presentation and immune response. Parasite Immunology, 26(11-12), 469-76.
Sternberg JM. Human African Trypanosomiasis: Clinical Presentation and Immune Response. Parasite Immunol. 2004 Nov-Dec;26(11-12):469-76. PubMed PMID: 15771682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human African trypanosomiasis: clinical presentation and immune response. A1 - Sternberg,J M, PY - 2005/3/18/pubmed PY - 2005/5/13/medline PY - 2005/3/18/entrez SP - 469 EP - 76 JF - Parasite immunology JO - Parasite Immunol VL - 26 IS - 11-12 N2 - Human African trypanosomiasis or sleeping sickness is caused by infection with two subspecies of the tsetse-fly-vectored haemoflagellate parasite Trypanosoma brucei. Historically, epidemic sleeping sickness has caused massive loss of life, and related animal diseases have had a crucial impact on development in sub-Saharan Africa. After a period of moderately successful control during the mid-part of the 20th century, sleeping sickness incidence is currently rising, and control is hampered by a combination of factors, including civil unrest and the possible development of drug resistance by the parasites. The prevailing view is that the disease is invariably fatal without anti-trypanosomal drug treatment. However, there have also been intriguing reports of wide variations in disease severity as well as evidence of asymptomatic carriers of trypanosomes. These differences in the presentation of the disease will be discussed in the context of our knowledge of the immunology of trypanosomiasis. The impact of dysregulated inflammatory responses in both systemic and CNS pathology will be examined and the potential for host genotype variation in disease severity and control will be discussed. SN - 0141-9838 UR - https://www.unboundmedicine.com/medline/citation/15771682/Human_African_trypanosomiasis:_clinical_presentation_and_immune_response_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0141-9838&date=2004&volume=26&issue=11-12&spage=469 DB - PRIME DP - Unbound Medicine ER -