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Dietary soy protein and isoflavones: minimal beneficial effects on bone and no effect on the reproductive tract of sexually mature ovariectomized Sprague-Dawley rats.
Menopause 2005; 12(2):165-73M

Abstract

OBJECTIVE

The present study was conducted to determine the effects of dietary soy protein and isoflavones on bone and the reproductive tract in the absence of the ovary.

DESIGN

Three-month-old Sprague-Dawley rats (n = 56) were either sham-operated or ovariectomized and then fed diets containing casein or soy protein +/- isoflavone extract for 12 weeks. The amounts of casein, soy protein, and extract (per kg diet) in each group were as follows: (1) Ovariectomy, 200 g of casein; (2) Ovariectomy+low soy, 100 g of casein + 100 g of soy protein; (3) Ovariectomy+high soy, 200 g of soy protein; (4) Ovariectomy+low extract, 200 g of casein + 17.2 g of extract; (5) Ovariectomy+high extract, 200 g of casein + 34.4 g of extract; (6) Ovary intact, 200 g of casein; (7) Ovariectomy+estradiol-17beta, 200 g of casein. Diet consumption, body weight, uterine weight, urine deoxypyridinoline, and bone mineral density of the femur and lumbar vertebrae were measured. The femur rigidity was evaluated by histomorphometry. The reproductive tract (uterus, vagina, and cervix) was studied histologically.

RESULTS

The Ovariectomy group showed significant increases in body weight, diet consumption, and deoxypyridinoline, decreases in uterine weight and bone mineral density, and negative changes in histomorphometry compared with the Ovary intact group. Neither soy protein nor extract diets abrogated these alterations, except for the Ovariectomy+high extract group that showed statistically significant positive changes in histomorphometric parameters. There were no histological differences in the reproductive tract among Ovariectomy, Ovariectomy+soy, and Ovariectomy+extract groups. The estradiol-17beta replacement abrogated ovariectomy-induced alterations.

CONCLUSION

Dietary intake of isoflavones by sexually mature ovariectomized rats has a minimal beneficial effect on bone with no effect on the reproductive tract.

Authors+Show Affiliations

Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA. jbahr@uiuc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15772564

Citation

Bahr, Janice M., et al. "Dietary Soy Protein and Isoflavones: Minimal Beneficial Effects On Bone and No Effect On the Reproductive Tract of Sexually Mature Ovariectomized Sprague-Dawley Rats." Menopause (New York, N.Y.), vol. 12, no. 2, 2005, pp. 165-73.
Bahr JM, Nakai M, Rivera A, et al. Dietary soy protein and isoflavones: minimal beneficial effects on bone and no effect on the reproductive tract of sexually mature ovariectomized Sprague-Dawley rats. Menopause. 2005;12(2):165-73.
Bahr, J. M., Nakai, M., Rivera, A., Walsh, J., Evans, G. L., Lotinun, S., ... Jeffery, E. H. (2005). Dietary soy protein and isoflavones: minimal beneficial effects on bone and no effect on the reproductive tract of sexually mature ovariectomized Sprague-Dawley rats. Menopause (New York, N.Y.), 12(2), pp. 165-73.
Bahr JM, et al. Dietary Soy Protein and Isoflavones: Minimal Beneficial Effects On Bone and No Effect On the Reproductive Tract of Sexually Mature Ovariectomized Sprague-Dawley Rats. Menopause. 2005;12(2):165-73. PubMed PMID: 15772564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary soy protein and isoflavones: minimal beneficial effects on bone and no effect on the reproductive tract of sexually mature ovariectomized Sprague-Dawley rats. AU - Bahr,Janice M, AU - Nakai,Masaaki, AU - Rivera,Alexander, AU - Walsh,Jane, AU - Evans,Glenda L, AU - Lotinun,Sutada, AU - Turner,Russell T, AU - Black,Molly, AU - Jeffery,Elizabeth H, PY - 2005/3/18/pubmed PY - 2005/7/22/medline PY - 2005/3/18/entrez SP - 165 EP - 73 JF - Menopause (New York, N.Y.) JO - Menopause VL - 12 IS - 2 N2 - OBJECTIVE: The present study was conducted to determine the effects of dietary soy protein and isoflavones on bone and the reproductive tract in the absence of the ovary. DESIGN: Three-month-old Sprague-Dawley rats (n = 56) were either sham-operated or ovariectomized and then fed diets containing casein or soy protein +/- isoflavone extract for 12 weeks. The amounts of casein, soy protein, and extract (per kg diet) in each group were as follows: (1) Ovariectomy, 200 g of casein; (2) Ovariectomy+low soy, 100 g of casein + 100 g of soy protein; (3) Ovariectomy+high soy, 200 g of soy protein; (4) Ovariectomy+low extract, 200 g of casein + 17.2 g of extract; (5) Ovariectomy+high extract, 200 g of casein + 34.4 g of extract; (6) Ovary intact, 200 g of casein; (7) Ovariectomy+estradiol-17beta, 200 g of casein. Diet consumption, body weight, uterine weight, urine deoxypyridinoline, and bone mineral density of the femur and lumbar vertebrae were measured. The femur rigidity was evaluated by histomorphometry. The reproductive tract (uterus, vagina, and cervix) was studied histologically. RESULTS: The Ovariectomy group showed significant increases in body weight, diet consumption, and deoxypyridinoline, decreases in uterine weight and bone mineral density, and negative changes in histomorphometry compared with the Ovary intact group. Neither soy protein nor extract diets abrogated these alterations, except for the Ovariectomy+high extract group that showed statistically significant positive changes in histomorphometric parameters. There were no histological differences in the reproductive tract among Ovariectomy, Ovariectomy+soy, and Ovariectomy+extract groups. The estradiol-17beta replacement abrogated ovariectomy-induced alterations. CONCLUSION: Dietary intake of isoflavones by sexually mature ovariectomized rats has a minimal beneficial effect on bone with no effect on the reproductive tract. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/15772564/Dietary_soy_protein_and_isoflavones:_minimal_beneficial_effects_on_bone_and_no_effect_on_the_reproductive_tract_of_sexually_mature_ovariectomized_Sprague_Dawley_rats_ L2 - http://Insights.ovid.com/pubmed?pmid=15772564 DB - PRIME DP - Unbound Medicine ER -