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The effect of short-term glycemic regulation with gliclazide and metformin on postprandial lipemia.
Exp Clin Endocrinol Diabetes. 2005 Feb; 113(2):80-4.EC

Abstract

AIM

Exaggerated postprandial lipemia is now accepted as an independent risk factor in atherogenesis in type 2 diabetes mellitus. We investigated if better glycemic control improves fasting and postprandial lipid profile in type 2 diabetic patients in the short-term.

METHODS

Thirty-two type 2 diabetic patients were studied before and after desired glycemic regulation with gliclazide and metformin. Basal levels of glucose, total cholesterol, high density lipoprotein, low density lipoprotein, triglyceride, insulin, and C-peptide were evaluated at fasting state. Afterwards, patients were given a standard 400-kcal mixed meal as a breakfast, contaning 35 % fat. At the 2nd and the 4th hours after the breakfast, postprandial glucose, triglyceride, insulin, and C-peptide levels were determined again.

RESULTS

Significant decrease was observed in total cholesterol levels after better glycemic regulation (p<0.05). Besides, triglyceride levels decreased significantly from 175.36+/-17.85 mg/dl to 138.73+/-14.93 mg/dl at fasting state (p<0.05), from 197.26+/-20.85 mg/dl to 154.15+/-14.61 mg/dl at the 2nd hour after mixed meal (p<0.05), and from 209.63+/-28.54 mg/dl to 155.63+/-15.68 mg/dl (p<0.05) at the 4th hour after the mixed meal, when better glycemic profile was provided. Area under curve for triglyceride levels decreased significantly with the better glycemic regulation (p<0.01).

CONCLUSIONS

Improved glycemic regulation can lower the raised fasting and postprandial triglyceride levels which are important atherosclerotic risk factors in diabetic patients even in short-term. Since this improvement in triglyceride levels comes early, diabetic patients can be evaluated for fasting and postprandial triglyceride levels in the first month of therapy.

Authors+Show Affiliations

Ankara University, School of Medicine, Department of Endocrinology and Metabolic Diseases, Ankara, Turkey. rifatemral@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15772898

Citation

Emral, R, et al. "The Effect of Short-term Glycemic Regulation With Gliclazide and Metformin On Postprandial Lipemia." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 113, no. 2, 2005, pp. 80-4.
Emral R, Köseoğlulari O, Tonyukuk V, et al. The effect of short-term glycemic regulation with gliclazide and metformin on postprandial lipemia. Exp Clin Endocrinol Diabetes. 2005;113(2):80-4.
Emral, R., Köseoğlulari, O., Tonyukuk, V., Uysal, A. R., Kamel, N., & Corapçioğlu, D. (2005). The effect of short-term glycemic regulation with gliclazide and metformin on postprandial lipemia. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 113(2), 80-4.
Emral R, et al. The Effect of Short-term Glycemic Regulation With Gliclazide and Metformin On Postprandial Lipemia. Exp Clin Endocrinol Diabetes. 2005;113(2):80-4. PubMed PMID: 15772898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of short-term glycemic regulation with gliclazide and metformin on postprandial lipemia. AU - Emral,R, AU - Köseoğlulari,O, AU - Tonyukuk,V, AU - Uysal,A R, AU - Kamel,N, AU - Corapçioğlu,D, PY - 2005/3/18/pubmed PY - 2005/7/1/medline PY - 2005/3/18/entrez SP - 80 EP - 4 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp Clin Endocrinol Diabetes VL - 113 IS - 2 N2 - AIM: Exaggerated postprandial lipemia is now accepted as an independent risk factor in atherogenesis in type 2 diabetes mellitus. We investigated if better glycemic control improves fasting and postprandial lipid profile in type 2 diabetic patients in the short-term. METHODS: Thirty-two type 2 diabetic patients were studied before and after desired glycemic regulation with gliclazide and metformin. Basal levels of glucose, total cholesterol, high density lipoprotein, low density lipoprotein, triglyceride, insulin, and C-peptide were evaluated at fasting state. Afterwards, patients were given a standard 400-kcal mixed meal as a breakfast, contaning 35 % fat. At the 2nd and the 4th hours after the breakfast, postprandial glucose, triglyceride, insulin, and C-peptide levels were determined again. RESULTS: Significant decrease was observed in total cholesterol levels after better glycemic regulation (p<0.05). Besides, triglyceride levels decreased significantly from 175.36+/-17.85 mg/dl to 138.73+/-14.93 mg/dl at fasting state (p<0.05), from 197.26+/-20.85 mg/dl to 154.15+/-14.61 mg/dl at the 2nd hour after mixed meal (p<0.05), and from 209.63+/-28.54 mg/dl to 155.63+/-15.68 mg/dl (p<0.05) at the 4th hour after the mixed meal, when better glycemic profile was provided. Area under curve for triglyceride levels decreased significantly with the better glycemic regulation (p<0.01). CONCLUSIONS: Improved glycemic regulation can lower the raised fasting and postprandial triglyceride levels which are important atherosclerotic risk factors in diabetic patients even in short-term. Since this improvement in triglyceride levels comes early, diabetic patients can be evaluated for fasting and postprandial triglyceride levels in the first month of therapy. SN - 0947-7349 UR - https://www.unboundmedicine.com/medline/citation/15772898/The_effect_of_short_term_glycemic_regulation_with_gliclazide_and_metformin_on_postprandial_lipemia_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-830536 DB - PRIME DP - Unbound Medicine ER -