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[Prevalence of anemia, calcium-phosphorus abnormalities and metabolic acidosis in different stages of chronic renal failure].
Pol Arch Med Wewn. 2004 Oct; 112(4):1211-9.PA

Abstract

BACKGROUND

Chronic kidney disease (CKD) is associated with the reduction of haemoglobin concentration and a variety of biochemical abnormalities including changes in serum concentration of sodium, potassium, calcium, phosphate, bicarbonate, and hydrogen ions. However, data concerning epidemiology of these abnormalities are rare and incomplete, especially among subjects with mild to moderate CKD.

PATIENTS AND METHODS

Patients with a serum creatinine concentration > 110 micromol/l hospitalized in the Department of Nephrology, Endocrinology and Metabolic Diseases Medical University of Silesia from 1998 to 2002 were analyzed. Patients with acute renal failure or chronic renal failure treated with renal replacement therapy were excluded from this study. A total of 653 patients (262F and 391M) were divided into 9 subgroups differing from each other by progressive decline of glomerular filtration rate (GFR).

RESULTS

A statistically significant decrease in haemoglobin concentration and increase in the prevalence of anaemia were found in patients with GFR < 50 ml/min. In a large number of patients with a GFR < 80 but > 50 ml/min, Hb concentration <11 g/dl was observed. Mean MCV, MCH and serum iron concentration were similar in all studied subgroups. A progressive increase in serum phosphorus concentration and decrease of calcaemia was found in patients with GFR < 30 ml/min. The elevated Ca x P product (> 4.44 mmol2/12) was noticed almost exclusively in patients with GFR< 30 ml/min. A decompensated metabolic acidosis was observed in 29.8% of patients with GFR <30 ml/min.

CONCLUSIONS

Anaemia is an early symptom of chronic kidney disease preceding disturbances of calcium, phosphate and hydrogen ions metabolism. These abnormalities seem to be of therapeutic relevance.

Authors+Show Affiliations

Katedra i Klinika Nefrologii, Endokrynologii i Chorób Przemiany Materii, Sl. AM w Katowicach.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

pol

PubMed ID

15773434

Citation

Zarzecki, Miłosz, et al. "[Prevalence of Anemia, Calcium-phosphorus Abnormalities and Metabolic Acidosis in Different Stages of Chronic Renal Failure]." Polskie Archiwum Medycyny Wewnetrznej, vol. 112, no. 4, 2004, pp. 1211-9.
Zarzecki M, Chudek J, Kukla M, et al. [Prevalence of anemia, calcium-phosphorus abnormalities and metabolic acidosis in different stages of chronic renal failure]. Pol Arch Med Wewn. 2004;112(4):1211-9.
Zarzecki, M., Chudek, J., Kukla, M., Kopeć, P., Mamcarz, E., Wnuk, Z., Kokot, F., & Wiecek, A. (2004). [Prevalence of anemia, calcium-phosphorus abnormalities and metabolic acidosis in different stages of chronic renal failure]. Polskie Archiwum Medycyny Wewnetrznej, 112(4), 1211-9.
Zarzecki M, et al. [Prevalence of Anemia, Calcium-phosphorus Abnormalities and Metabolic Acidosis in Different Stages of Chronic Renal Failure]. Pol Arch Med Wewn. 2004;112(4):1211-9. PubMed PMID: 15773434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prevalence of anemia, calcium-phosphorus abnormalities and metabolic acidosis in different stages of chronic renal failure]. AU - Zarzecki,Miłosz, AU - Chudek,Jerzy, AU - Kukla,Małgorzata, AU - Kopeć,Paulina, AU - Mamcarz,Ewelina, AU - Wnuk,Zuzanna, AU - Kokot,Franciszek, AU - Wiecek,Andrzej, PY - 2005/3/19/pubmed PY - 2005/5/13/medline PY - 2005/3/19/entrez SP - 1211 EP - 9 JF - Polskie Archiwum Medycyny Wewnetrznej JO - Pol Arch Med Wewn VL - 112 IS - 4 N2 - BACKGROUND: Chronic kidney disease (CKD) is associated with the reduction of haemoglobin concentration and a variety of biochemical abnormalities including changes in serum concentration of sodium, potassium, calcium, phosphate, bicarbonate, and hydrogen ions. However, data concerning epidemiology of these abnormalities are rare and incomplete, especially among subjects with mild to moderate CKD. PATIENTS AND METHODS: Patients with a serum creatinine concentration > 110 micromol/l hospitalized in the Department of Nephrology, Endocrinology and Metabolic Diseases Medical University of Silesia from 1998 to 2002 were analyzed. Patients with acute renal failure or chronic renal failure treated with renal replacement therapy were excluded from this study. A total of 653 patients (262F and 391M) were divided into 9 subgroups differing from each other by progressive decline of glomerular filtration rate (GFR). RESULTS: A statistically significant decrease in haemoglobin concentration and increase in the prevalence of anaemia were found in patients with GFR < 50 ml/min. In a large number of patients with a GFR < 80 but > 50 ml/min, Hb concentration <11 g/dl was observed. Mean MCV, MCH and serum iron concentration were similar in all studied subgroups. A progressive increase in serum phosphorus concentration and decrease of calcaemia was found in patients with GFR < 30 ml/min. The elevated Ca x P product (> 4.44 mmol2/12) was noticed almost exclusively in patients with GFR< 30 ml/min. A decompensated metabolic acidosis was observed in 29.8% of patients with GFR <30 ml/min. CONCLUSIONS: Anaemia is an early symptom of chronic kidney disease preceding disturbances of calcium, phosphate and hydrogen ions metabolism. These abnormalities seem to be of therapeutic relevance. UR - https://www.unboundmedicine.com/medline/citation/15773434/[Prevalence_of_anemia_calcium_phosphorus_abnormalities_and_metabolic_acidosis_in_different_stages_of_chronic_renal_failure]_ L2 - http://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -