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Alterations of antioxidant trace elements (Zn, Se, Cu) and related metallo-enzymes in plasma and tissues following burn injury in rats.
Burns. 2005 May; 31(3):366-71.B

Abstract

To improve the nutritional support for burn patients, we evaluated the alterations of selenium, zinc and copper (Se, Zn and Cu) and their possible contributions to an unbalanced antioxidant response to burn injury. These trace elements and the related antioxidant enzymes, glutathione peroxidase (GPx) and superoxide dismutase (SOD), were studied both in plasma (or serum) and tissues of 20% total body surface area (TBSA) burned rats for 10 days. While plasma Se and serum Zn levels significantly decreased 6 h after burn injury, serum Cu levels increased after 1 day and remained elevated the following 9 days. Selenium levels increased in kidney but decreased progressively in liver. The hepatic Zn and Cu concentrations followed a biphasic increase following burn injury. During the first day, GPx activity decreased in plasma and remained unchanged in the organs, except for a moderate diminution in the liver. Liver Cu/Zn SOD activity increased from 6 h to 4 days. In summary, following burn injury, copper and zinc were redistributed to the liver and selenium to the kidney with non-detectable changes in the muscle and brain. Changes in antioxidant enzyme activities following burn injury were significant mainly in the plasma. Early combined antioxidant supplementation to maintain and restore antioxidant status in burn patients requires further study.

Authors+Show Affiliations

Centre de Recherches du Service de Santé des Armées, 24 Avenue du Maquis du Grésivaudan, BP87, 38702 La Tronche Cedex, France. diane.agay@crssa.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15774296

Citation

Agay, D, et al. "Alterations of Antioxidant Trace Elements (Zn, Se, Cu) and Related Metallo-enzymes in Plasma and Tissues Following Burn Injury in Rats." Burns : Journal of the International Society for Burn Injuries, vol. 31, no. 3, 2005, pp. 366-71.
Agay D, Anderson RA, Sandre C, et al. Alterations of antioxidant trace elements (Zn, Se, Cu) and related metallo-enzymes in plasma and tissues following burn injury in rats. Burns. 2005;31(3):366-71.
Agay, D., Anderson, R. A., Sandre, C., Bryden, N. A., Alonso, A., Roussel, A. M., & Chancerelle, Y. (2005). Alterations of antioxidant trace elements (Zn, Se, Cu) and related metallo-enzymes in plasma and tissues following burn injury in rats. Burns : Journal of the International Society for Burn Injuries, 31(3), 366-71.
Agay D, et al. Alterations of Antioxidant Trace Elements (Zn, Se, Cu) and Related Metallo-enzymes in Plasma and Tissues Following Burn Injury in Rats. Burns. 2005;31(3):366-71. PubMed PMID: 15774296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations of antioxidant trace elements (Zn, Se, Cu) and related metallo-enzymes in plasma and tissues following burn injury in rats. AU - Agay,D, AU - Anderson,R A, AU - Sandre,C, AU - Bryden,N A, AU - Alonso,A, AU - Roussel,A M, AU - Chancerelle,Y, PY - 2004/09/09/received PY - 2004/11/10/accepted PY - 2005/3/19/pubmed PY - 2005/8/27/medline PY - 2005/3/19/entrez SP - 366 EP - 71 JF - Burns : journal of the International Society for Burn Injuries JO - Burns VL - 31 IS - 3 N2 - To improve the nutritional support for burn patients, we evaluated the alterations of selenium, zinc and copper (Se, Zn and Cu) and their possible contributions to an unbalanced antioxidant response to burn injury. These trace elements and the related antioxidant enzymes, glutathione peroxidase (GPx) and superoxide dismutase (SOD), were studied both in plasma (or serum) and tissues of 20% total body surface area (TBSA) burned rats for 10 days. While plasma Se and serum Zn levels significantly decreased 6 h after burn injury, serum Cu levels increased after 1 day and remained elevated the following 9 days. Selenium levels increased in kidney but decreased progressively in liver. The hepatic Zn and Cu concentrations followed a biphasic increase following burn injury. During the first day, GPx activity decreased in plasma and remained unchanged in the organs, except for a moderate diminution in the liver. Liver Cu/Zn SOD activity increased from 6 h to 4 days. In summary, following burn injury, copper and zinc were redistributed to the liver and selenium to the kidney with non-detectable changes in the muscle and brain. Changes in antioxidant enzyme activities following burn injury were significant mainly in the plasma. Early combined antioxidant supplementation to maintain and restore antioxidant status in burn patients requires further study. SN - 0305-4179 UR - https://www.unboundmedicine.com/medline/citation/15774296/Alterations_of_antioxidant_trace_elements__Zn_Se_Cu__and_related_metallo_enzymes_in_plasma_and_tissues_following_burn_injury_in_rats_ DB - PRIME DP - Unbound Medicine ER -