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Flow-mediated dilatation is impaired by a high-saturated fat diet but not by a high-carbohydrate diet.
Arterioscler Thromb Vasc Biol 2005; 25(6):1274-9AT

Abstract

OBJECTIVE

It is unknown whether a low-fat diet, which may elevate triglycerides and lower high-density lipoprotein (HDL) cholesterol, harms the endothelium. Our aim was to determine whether a low-fat, high-carbohydrate (CARB) diet impaired endothelial vasodilation compared with high saturated fat (SFA), monounsaturated fat (MUFA), or polyunsaturated fat (PUFA) diets.

METHODS AND RESULTS

Forty healthy subjects were randomly crossed over to 4, 3-week isocaloric diets high in PUFA, MUFA, or SFA, containing at least 25 g of the relevant fat or a low-fat, CARB, high-glycemic load diet. Flow-mediated dilatation (FMD), fasting blood lipids, high sensitivity C-reactive protein, plasma intercellular, and vascular adhesion molecules plasma E- and P-selectin were measured after each intervention. SFA impaired FMD compared with all other diets (5.41+/-2.45% versus 10.80+/-3.69%; P=0.01). FMD did not change on CARB relative to MUFA or PUFA, despite 23% to 39% rises in triglyceride and 10% to 15% falls in HDL cholesterol. P-selectin was highest after SFA (121+/-52.7 ng/mL) versus MUFA (98+/-44.5 ng/mL; P=0.001) and PUFA (96+/-36.4 ng/mL; P=0.001).

CONCLUSIONS

High SFA caused deterioration in FMD compared with high PUFA, MUFA, or CARB diets. Inflammatory responses may also be increased on this diet.

Authors+Show Affiliations

CSIRO Health Sciences and Nutrition, Adelaide BC, South Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15774905

Citation

Keogh, Jennifer B., et al. "Flow-mediated Dilatation Is Impaired By a High-saturated Fat Diet but Not By a High-carbohydrate Diet." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 6, 2005, pp. 1274-9.
Keogh JB, Grieger JA, Noakes M, et al. Flow-mediated dilatation is impaired by a high-saturated fat diet but not by a high-carbohydrate diet. Arterioscler Thromb Vasc Biol. 2005;25(6):1274-9.
Keogh, J. B., Grieger, J. A., Noakes, M., & Clifton, P. M. (2005). Flow-mediated dilatation is impaired by a high-saturated fat diet but not by a high-carbohydrate diet. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(6), pp. 1274-9.
Keogh JB, et al. Flow-mediated Dilatation Is Impaired By a High-saturated Fat Diet but Not By a High-carbohydrate Diet. Arterioscler Thromb Vasc Biol. 2005;25(6):1274-9. PubMed PMID: 15774905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flow-mediated dilatation is impaired by a high-saturated fat diet but not by a high-carbohydrate diet. AU - Keogh,Jennifer B, AU - Grieger,Jessica A, AU - Noakes,Manny, AU - Clifton,Peter M, Y1 - 2005/03/17/ PY - 2005/3/19/pubmed PY - 2005/12/22/medline PY - 2005/3/19/entrez SP - 1274 EP - 9 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 25 IS - 6 N2 - OBJECTIVE: It is unknown whether a low-fat diet, which may elevate triglycerides and lower high-density lipoprotein (HDL) cholesterol, harms the endothelium. Our aim was to determine whether a low-fat, high-carbohydrate (CARB) diet impaired endothelial vasodilation compared with high saturated fat (SFA), monounsaturated fat (MUFA), or polyunsaturated fat (PUFA) diets. METHODS AND RESULTS: Forty healthy subjects were randomly crossed over to 4, 3-week isocaloric diets high in PUFA, MUFA, or SFA, containing at least 25 g of the relevant fat or a low-fat, CARB, high-glycemic load diet. Flow-mediated dilatation (FMD), fasting blood lipids, high sensitivity C-reactive protein, plasma intercellular, and vascular adhesion molecules plasma E- and P-selectin were measured after each intervention. SFA impaired FMD compared with all other diets (5.41+/-2.45% versus 10.80+/-3.69%; P=0.01). FMD did not change on CARB relative to MUFA or PUFA, despite 23% to 39% rises in triglyceride and 10% to 15% falls in HDL cholesterol. P-selectin was highest after SFA (121+/-52.7 ng/mL) versus MUFA (98+/-44.5 ng/mL; P=0.001) and PUFA (96+/-36.4 ng/mL; P=0.001). CONCLUSIONS: High SFA caused deterioration in FMD compared with high PUFA, MUFA, or CARB diets. Inflammatory responses may also be increased on this diet. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/15774905/Flow_mediated_dilatation_is_impaired_by_a_high_saturated_fat_diet_but_not_by_a_high_carbohydrate_diet_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000163185.28245.a1?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -