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Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model.
Br J Ophthalmol. 2005 Apr; 89(4):504-7.BJ

Abstract

AIMS

This study sought to elucidate the effects of timolol and dorzolamide on intraocular pressure (IOP) and retinal ganglion cell (RGC) death in an experimental model of glaucoma in rat.

METHODS

Mild elevation of IOP was induced in rats by intracameral injection of India ink and subsequent laser trabecular photocoagulation. IOP was measured before the surgical procedures and weekly thereafter. Timolol (0.5%), timolol XE (0.5%), dorzolamide (1%), and artificial tears (vehicle) were topically applied daily. Retinal sections were prepared for histology to determine RGC number.

RESULTS

Timolol, timolol XE, and dorzolamide induced a significant reduction in IOP (p<0.05) and counteracted the reduction in RGC number that occurred in vehicle treated glaucomatous eyes (p<0.05). The coefficient of correlation between RGC number and IOP was significant in the dorzolamide treated group (r = -0.908, p<0.005), but not in other groups (p>0.05).

CONCLUSIONS

Both timolol formulation and dorzolamide reduced IOP and protected RGCs in a rat model of experimental glaucoma. It cannot be ruled out that timolol might protect RGCs by additional mechanisms other than simply lowering of IOP.

Authors+Show Affiliations

Division of Ophthalmology and Visual Science, Graduated School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi, Niigata, Niigata 951-8585, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15774933

Citation

Seki, M, et al. "Topically Administered Timolol and Dorzolamide Reduce Intraocular Pressure and Protect Retinal Ganglion Cells in a Rat Experimental Glaucoma Model." The British Journal of Ophthalmology, vol. 89, no. 4, 2005, pp. 504-7.
Seki M, Tanaka T, Matsuda H, et al. Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model. Br J Ophthalmol. 2005;89(4):504-7.
Seki, M., Tanaka, T., Matsuda, H., Togano, T., Hashimoto, K., Ueda, J., Fukuchi, T., & Abe, H. (2005). Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model. The British Journal of Ophthalmology, 89(4), 504-7.
Seki M, et al. Topically Administered Timolol and Dorzolamide Reduce Intraocular Pressure and Protect Retinal Ganglion Cells in a Rat Experimental Glaucoma Model. Br J Ophthalmol. 2005;89(4):504-7. PubMed PMID: 15774933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model. AU - Seki,M, AU - Tanaka,T, AU - Matsuda,H, AU - Togano,T, AU - Hashimoto,K, AU - Ueda,J, AU - Fukuchi,T, AU - Abe,H, PY - 2005/3/19/pubmed PY - 2005/4/15/medline PY - 2005/3/19/entrez SP - 504 EP - 7 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 89 IS - 4 N2 - AIMS: This study sought to elucidate the effects of timolol and dorzolamide on intraocular pressure (IOP) and retinal ganglion cell (RGC) death in an experimental model of glaucoma in rat. METHODS: Mild elevation of IOP was induced in rats by intracameral injection of India ink and subsequent laser trabecular photocoagulation. IOP was measured before the surgical procedures and weekly thereafter. Timolol (0.5%), timolol XE (0.5%), dorzolamide (1%), and artificial tears (vehicle) were topically applied daily. Retinal sections were prepared for histology to determine RGC number. RESULTS: Timolol, timolol XE, and dorzolamide induced a significant reduction in IOP (p<0.05) and counteracted the reduction in RGC number that occurred in vehicle treated glaucomatous eyes (p<0.05). The coefficient of correlation between RGC number and IOP was significant in the dorzolamide treated group (r = -0.908, p<0.005), but not in other groups (p>0.05). CONCLUSIONS: Both timolol formulation and dorzolamide reduced IOP and protected RGCs in a rat model of experimental glaucoma. It cannot be ruled out that timolol might protect RGCs by additional mechanisms other than simply lowering of IOP. SN - 0007-1161 UR - https://www.unboundmedicine.com/medline/citation/15774933/Topically_administered_timolol_and_dorzolamide_reduce_intraocular_pressure_and_protect_retinal_ganglion_cells_in_a_rat_experimental_glaucoma_model_ L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&amp;pmid=15774933 DB - PRIME DP - Unbound Medicine ER -