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Effects of drink volume and glucose load on gastric emptying and postprandial blood pressure in healthy older subjects.
Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G240-8.AJ

Abstract

Postprandial hypotension (PPH) occurs frequently in the elderly; the magnitude of the fall in blood pressure (BP) is related to the rate of glucose entry into the duodenum during intraduodenal glucose infusion and spontaneous gastric emptying (GE). It is unclear if glucose concentration affects the hypotensive response. Gastric distension may attenuate PPH; therefore, meal volume could influence the BP response. We aimed to determine the effects of 1) drink volume, 2) glucose concentration, and 3) glucose content on the BP and heart rate (HR) responses to oral glucose. Ten subjects (73.9 +/- 1.2 yr) had measurements of BP, GE, and blood glucose on 4 days after 1) 25 g glucose in 200 ml (12.5%), 2) 75 g glucose in 200 ml (37.5%), 3) 25 g glucose in 600 ml (4%), and 4) 75 g glucose in 600 ml (12.5%). GE, BP, HR, and blood glucose were measured for 180 min. After all drinks, duodenal glucose loads were similar in the first 60 min. Regardless of concentration, 600-ml (but not 200-ml) drinks initially increased BP, and in the first 30 min, systolic BP correlated (P < 0.01) with volume in both the proximal and total stomach. At the same concentration (12.5%), systolic BP fell more (P = 0.02) at the smaller volume; at the same volumes, there were no effects of concentration on BP. There was no difference in the glycemic response to drinks of identical glucose content. We conclude that 1) ingestion of glucose at a higher volume attenuates and 2) under constant duodenal load, glucose concentration (4-37%) does not affect the fall in BP.

Authors+Show Affiliations

Department of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia. karen.jones@adelaide.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15774941

Citation

Jones, Karen L., et al. "Effects of Drink Volume and Glucose Load On Gastric Emptying and Postprandial Blood Pressure in Healthy Older Subjects." American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 289, no. 2, 2005, pp. G240-8.
Jones KL, O'Donovan D, Russo A, et al. Effects of drink volume and glucose load on gastric emptying and postprandial blood pressure in healthy older subjects. Am J Physiol Gastrointest Liver Physiol. 2005;289(2):G240-8.
Jones, K. L., O'Donovan, D., Russo, A., Meyer, J. H., Stevens, J. E., Lei, Y., Keogh, J., Tonkin, A., & Horowitz, M. (2005). Effects of drink volume and glucose load on gastric emptying and postprandial blood pressure in healthy older subjects. American Journal of Physiology. Gastrointestinal and Liver Physiology, 289(2), G240-8.
Jones KL, et al. Effects of Drink Volume and Glucose Load On Gastric Emptying and Postprandial Blood Pressure in Healthy Older Subjects. Am J Physiol Gastrointest Liver Physiol. 2005;289(2):G240-8. PubMed PMID: 15774941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of drink volume and glucose load on gastric emptying and postprandial blood pressure in healthy older subjects. AU - Jones,Karen L, AU - O'Donovan,Deirdre, AU - Russo,Antonietta, AU - Meyer,James H, AU - Stevens,Julie E, AU - Lei,Yong, AU - Keogh,Jennifer, AU - Tonkin,Anne, AU - Horowitz,Michael, Y1 - 2005/03/17/ PY - 2005/3/19/pubmed PY - 2005/9/1/medline PY - 2005/3/19/entrez SP - G240 EP - 8 JF - American journal of physiology. Gastrointestinal and liver physiology JO - Am J Physiol Gastrointest Liver Physiol VL - 289 IS - 2 N2 - Postprandial hypotension (PPH) occurs frequently in the elderly; the magnitude of the fall in blood pressure (BP) is related to the rate of glucose entry into the duodenum during intraduodenal glucose infusion and spontaneous gastric emptying (GE). It is unclear if glucose concentration affects the hypotensive response. Gastric distension may attenuate PPH; therefore, meal volume could influence the BP response. We aimed to determine the effects of 1) drink volume, 2) glucose concentration, and 3) glucose content on the BP and heart rate (HR) responses to oral glucose. Ten subjects (73.9 +/- 1.2 yr) had measurements of BP, GE, and blood glucose on 4 days after 1) 25 g glucose in 200 ml (12.5%), 2) 75 g glucose in 200 ml (37.5%), 3) 25 g glucose in 600 ml (4%), and 4) 75 g glucose in 600 ml (12.5%). GE, BP, HR, and blood glucose were measured for 180 min. After all drinks, duodenal glucose loads were similar in the first 60 min. Regardless of concentration, 600-ml (but not 200-ml) drinks initially increased BP, and in the first 30 min, systolic BP correlated (P < 0.01) with volume in both the proximal and total stomach. At the same concentration (12.5%), systolic BP fell more (P = 0.02) at the smaller volume; at the same volumes, there were no effects of concentration on BP. There was no difference in the glycemic response to drinks of identical glucose content. We conclude that 1) ingestion of glucose at a higher volume attenuates and 2) under constant duodenal load, glucose concentration (4-37%) does not affect the fall in BP. SN - 0193-1857 UR - https://www.unboundmedicine.com/medline/citation/15774941/Effects_of_drink_volume_and_glucose_load_on_gastric_emptying_and_postprandial_blood_pressure_in_healthy_older_subjects_ L2 - https://journals.physiology.org/doi/10.1152/ajpgi.00030.2005?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -