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Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence.
Digestion. 2005; 71(2):97-105.D

Abstract

BACKGROUND/AIMS

Cholelithiasis is a common disorder in north-eastern Germany. Analyses of risk factors for gallstone formation in this population may have high explanatory power. Gender-specific risk factors for gallstone formation and their interactions were investigated by using data of the population-based Study of Health in Pomerania (SHIP).

METHODS

Data of 4,202 persons aged 20-79 years were available. Cholelithiasis was defined by either a prior history of cholecystectomy or the presence of gallstones on abdominal ultrasound. Multivariable analyses were performed to identify independent risk factors for gallstone formation.

RESULTS

There were 468 persons (11.1%) with previous cholecystectomy and 423 persons (10.1%) with sonographic evidence of gallstones. Women had a twofold higher risk for cholelithiasis compared to men. Age, body mass index and low serum HDL cholesterol levels were independently associated with cholelithiasis in both men and women. In the male population, low alcohol and high coffee consumption and in the female population, low physical activity, were further independently related to gallstone formation. Additionally, sex-specific interactions between risk factors were found.

CONCLUSIONS

Female sex, age and being overweight are major risk factors for gallstone formation in this region where cholelithiasis is a frequent disorder. Additional factors and interactions contribute to a gender-specific gallstone risk.

Authors+Show Affiliations

Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University, Greifswald, Germany. voelzke@uni-greifswald.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15775677

Citation

Völzke, Henry, et al. "Independent Risk Factors for Gallstone Formation in a Region With High Cholelithiasis Prevalence." Digestion, vol. 71, no. 2, 2005, pp. 97-105.
Völzke H, Baumeister SE, Alte D, et al. Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion. 2005;71(2):97-105.
Völzke, H., Baumeister, S. E., Alte, D., Hoffmann, W., Schwahn, C., Simon, P., John, U., & Lerch, M. M. (2005). Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion, 71(2), 97-105.
Völzke H, et al. Independent Risk Factors for Gallstone Formation in a Region With High Cholelithiasis Prevalence. Digestion. 2005;71(2):97-105. PubMed PMID: 15775677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. AU - Völzke,Henry, AU - Baumeister,Sebastian E, AU - Alte,Dietrich, AU - Hoffmann,Wolfgang, AU - Schwahn,Christian, AU - Simon,Peter, AU - John,Ulrich, AU - Lerch,Markus M, Y1 - 2005/03/16/ PY - 2004/09/06/received PY - 2004/11/12/accepted PY - 2005/3/19/pubmed PY - 2005/7/12/medline PY - 2005/3/19/entrez SP - 97 EP - 105 JF - Digestion JO - Digestion VL - 71 IS - 2 N2 - BACKGROUND/AIMS: Cholelithiasis is a common disorder in north-eastern Germany. Analyses of risk factors for gallstone formation in this population may have high explanatory power. Gender-specific risk factors for gallstone formation and their interactions were investigated by using data of the population-based Study of Health in Pomerania (SHIP). METHODS: Data of 4,202 persons aged 20-79 years were available. Cholelithiasis was defined by either a prior history of cholecystectomy or the presence of gallstones on abdominal ultrasound. Multivariable analyses were performed to identify independent risk factors for gallstone formation. RESULTS: There were 468 persons (11.1%) with previous cholecystectomy and 423 persons (10.1%) with sonographic evidence of gallstones. Women had a twofold higher risk for cholelithiasis compared to men. Age, body mass index and low serum HDL cholesterol levels were independently associated with cholelithiasis in both men and women. In the male population, low alcohol and high coffee consumption and in the female population, low physical activity, were further independently related to gallstone formation. Additionally, sex-specific interactions between risk factors were found. CONCLUSIONS: Female sex, age and being overweight are major risk factors for gallstone formation in this region where cholelithiasis is a frequent disorder. Additional factors and interactions contribute to a gender-specific gallstone risk. SN - 0012-2823 UR - https://www.unboundmedicine.com/medline/citation/15775677/Independent_risk_factors_for_gallstone_formation_in_a_region_with_high_cholelithiasis_prevalence_ L2 - https://www.karger.com?DOI=10.1159/000084525 DB - PRIME DP - Unbound Medicine ER -