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Efficacy of sufentanil addition to ropivacaine epidural anaesthesia for Caesarean section.
Acta Anaesthesiol Scand. 2005 Apr; 49(4):532-7.AA

Abstract

BACKGROUND

This prospective double-blind trial evaluated the effect of sufentanil addition to epidural ropivacaine for elective Caesarean section.

METHODS

Sixty healthy parturients were randomly assigned to receive an initial dose of 90 mg of plain ropivacaine, or 90 mg of ropivacaine plus 10 or 20 microg of sufentanil (n = 20 each). Before surgery, if necessary, additional epidural ropivacaine was injected. Primary outcome parameter was time to achieve sensory block at T4.

RESULTS

Time to reach the sensory block was remarkably reduced (P < 0.001 each) by addition of 10 or 20 microg of sufentanil (21 +/- 8 min, 15 +/- 5 min, 11 +/- 4 min in the plain ropivacaine, the 10- and 20-microg sufentanil groups, respectively) whereas the visual analogue scale (VAS) scores at delivery were significantly reduced (P = 0.028) only by 20 microg of sufentanil (32 +/- 35 mm in the plain ropivacaine vs. 9 +/- 19 mm in the 20-microg sufentanil groups). The total dose of ropivacaine was significantly lower (P = 0.005) in patients receiving 20 microg of sufentanil (100.5 +/- 15.0 mg) compared with those treated with plain ropivacaine (118.5 +/- 17.3 mg). The incidence of maternal side-effects (hypotension, bradycardia, nausea, vomiting, shivering, pruritus) and neonatal outcome [APGAR score, neurologic and adaptive capacity (NAC) score, umbilical cord blood-gas values] did not differ between the groups.

CONCLUSION

Our results suggest that addition of 20 microg of sufentanil improved the epidural anaesthesia with ropivacaine 0.75% for Caesarean section.

Authors+Show Affiliations

Department of Anaesthesiology, Klinikum Minden, Minden, St. Vincentius Kliniken, Karlsruhe and Klinikum Bamberg, Germany. b.bachmann-m@klinikum-minden.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15777302

Citation

Bachmann-Mennenga, B, et al. "Efficacy of Sufentanil Addition to Ropivacaine Epidural Anaesthesia for Caesarean Section." Acta Anaesthesiologica Scandinavica, vol. 49, no. 4, 2005, pp. 532-7.
Bachmann-Mennenga B, Veit G, Steinicke B, et al. Efficacy of sufentanil addition to ropivacaine epidural anaesthesia for Caesarean section. Acta Anaesthesiol Scand. 2005;49(4):532-7.
Bachmann-Mennenga, B., Veit, G., Steinicke, B., Biscoping, J., & Heesen, M. (2005). Efficacy of sufentanil addition to ropivacaine epidural anaesthesia for Caesarean section. Acta Anaesthesiologica Scandinavica, 49(4), 532-7.
Bachmann-Mennenga B, et al. Efficacy of Sufentanil Addition to Ropivacaine Epidural Anaesthesia for Caesarean Section. Acta Anaesthesiol Scand. 2005;49(4):532-7. PubMed PMID: 15777302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of sufentanil addition to ropivacaine epidural anaesthesia for Caesarean section. AU - Bachmann-Mennenga,B, AU - Veit,G, AU - Steinicke,B, AU - Biscoping,J, AU - Heesen,M, PY - 2005/3/22/pubmed PY - 2005/6/25/medline PY - 2005/3/22/entrez SP - 532 EP - 7 JF - Acta anaesthesiologica Scandinavica JO - Acta Anaesthesiol Scand VL - 49 IS - 4 N2 - BACKGROUND: This prospective double-blind trial evaluated the effect of sufentanil addition to epidural ropivacaine for elective Caesarean section. METHODS: Sixty healthy parturients were randomly assigned to receive an initial dose of 90 mg of plain ropivacaine, or 90 mg of ropivacaine plus 10 or 20 microg of sufentanil (n = 20 each). Before surgery, if necessary, additional epidural ropivacaine was injected. Primary outcome parameter was time to achieve sensory block at T4. RESULTS: Time to reach the sensory block was remarkably reduced (P < 0.001 each) by addition of 10 or 20 microg of sufentanil (21 +/- 8 min, 15 +/- 5 min, 11 +/- 4 min in the plain ropivacaine, the 10- and 20-microg sufentanil groups, respectively) whereas the visual analogue scale (VAS) scores at delivery were significantly reduced (P = 0.028) only by 20 microg of sufentanil (32 +/- 35 mm in the plain ropivacaine vs. 9 +/- 19 mm in the 20-microg sufentanil groups). The total dose of ropivacaine was significantly lower (P = 0.005) in patients receiving 20 microg of sufentanil (100.5 +/- 15.0 mg) compared with those treated with plain ropivacaine (118.5 +/- 17.3 mg). The incidence of maternal side-effects (hypotension, bradycardia, nausea, vomiting, shivering, pruritus) and neonatal outcome [APGAR score, neurologic and adaptive capacity (NAC) score, umbilical cord blood-gas values] did not differ between the groups. CONCLUSION: Our results suggest that addition of 20 microg of sufentanil improved the epidural anaesthesia with ropivacaine 0.75% for Caesarean section. SN - 0001-5172 UR - https://www.unboundmedicine.com/medline/citation/15777302/Efficacy_of_sufentanil_addition_to_ropivacaine_epidural_anaesthesia_for_Caesarean_section_ L2 - https://doi.org/10.1111/j.1399-6576.2005.00657.x DB - PRIME DP - Unbound Medicine ER -