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Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: a prospective British birth cohort study.
BJOG 2005; 112(4):476-85BJOG

Abstract

OBJECTIVES

To investigate cardiovascular risk factors and changes in risk factor levels in relation to menopausal stage, hysterectomy status and hormone replacement therapy use in a cohort of women aged 53 years with prospective data on smoking, lifetime socio-economic circumstances, and blood pressure and obesity at age 43 years.

DESIGN

A prospective study.

SETTING

England, Scotland and Wales.

POPULATION

A cohort of women from the Medical Research Council Survey of Health and Development.

METHODS

A total of 1303 women, aged 53 years, from a UK birth cohort study with measures of cardiovascular risk factors were classified by five menopausal status groups (premenopause, perimenopause, postmenopause, hysterectomy and hormone replacement therapy user). Body mass index, glycosolated haemoglobin, blood pressure, high density lipoprotein, low density lipoprotein and total cholesterol measurements were taken, and analysed within the groups taking confounding variables into account. Changes in body mass index and blood pressure measurement in the same women obtained when 43 years of age were also compared.

MAIN OUTCOME MEASURES

Body mass index, glycosolated haemoglobin, blood pressure, high density lipoprotein, low density lipoprotein and total cholesterol.

RESULTS

At 53 years, body mass index, waist circumference, total and low density lipoprotein cholesterol, and glycosolated haemoglobin (HbA1c) varied by menopausal status group, but blood pressure did not. Levels of total cholesterol and HbA1c increased across the natural menopause transition, before and after adjustment for body mass index, smoking and lifetime socio-economic circumstances. After adjustment for confounders, levels of risk factors for hysterectomised women were similar to those of naturally postmenopausal women. Women on hormone replacement therapy had lower levels of total and low density lipoprotein cholesterol, HbA1c, and were less obese than postmenopausal women. The lower obesity levels were partly due to these women already being less obese at age 43 years.

CONCLUSIONS

This study showed that naturally postmenopausal or hysterectomised women had higher levels of metabolic risk factors compared with premenopausal or perimenopausal women of the same age. The long term stability of these differences and their translation into variations in incidence of cardiovascular disease remain to be seen. The lower levels of metabolic risk factors for women on hormone replacement therapy may protect against future cardiovascular disease or may be overwhelmed by other adverse, and as yet unknown, effects of hormone replacement therapy.

Authors+Show Affiliations

MRC National Survey of Health and Development, Department of Epidemiology and Public Health, Royal Free and University College Medical School, 1-19 Torrington Place, London WC1E 6BT, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15777448

Citation

Kuh, D, et al. "Cardiovascular Risk at Age 53 Years in Relation to the Menopause Transition and Use of Hormone Replacement Therapy: a Prospective British Birth Cohort Study." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 112, no. 4, 2005, pp. 476-85.
Kuh D, Langenberg C, Hardy R, et al. Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: a prospective British birth cohort study. BJOG. 2005;112(4):476-85.
Kuh, D., Langenberg, C., Hardy, R., Kok, H., Cooper, R., Butterworth, S., & Wadsworth, M. E. (2005). Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: a prospective British birth cohort study. BJOG : an International Journal of Obstetrics and Gynaecology, 112(4), pp. 476-85.
Kuh D, et al. Cardiovascular Risk at Age 53 Years in Relation to the Menopause Transition and Use of Hormone Replacement Therapy: a Prospective British Birth Cohort Study. BJOG. 2005;112(4):476-85. PubMed PMID: 15777448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: a prospective British birth cohort study. AU - Kuh,D, AU - Langenberg,C, AU - Hardy,R, AU - Kok,H, AU - Cooper,R, AU - Butterworth,S, AU - Wadsworth,M E J, PY - 2005/3/22/pubmed PY - 2005/5/17/medline PY - 2005/3/22/entrez SP - 476 EP - 85 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 112 IS - 4 N2 - OBJECTIVES: To investigate cardiovascular risk factors and changes in risk factor levels in relation to menopausal stage, hysterectomy status and hormone replacement therapy use in a cohort of women aged 53 years with prospective data on smoking, lifetime socio-economic circumstances, and blood pressure and obesity at age 43 years. DESIGN: A prospective study. SETTING: England, Scotland and Wales. POPULATION: A cohort of women from the Medical Research Council Survey of Health and Development. METHODS: A total of 1303 women, aged 53 years, from a UK birth cohort study with measures of cardiovascular risk factors were classified by five menopausal status groups (premenopause, perimenopause, postmenopause, hysterectomy and hormone replacement therapy user). Body mass index, glycosolated haemoglobin, blood pressure, high density lipoprotein, low density lipoprotein and total cholesterol measurements were taken, and analysed within the groups taking confounding variables into account. Changes in body mass index and blood pressure measurement in the same women obtained when 43 years of age were also compared. MAIN OUTCOME MEASURES: Body mass index, glycosolated haemoglobin, blood pressure, high density lipoprotein, low density lipoprotein and total cholesterol. RESULTS: At 53 years, body mass index, waist circumference, total and low density lipoprotein cholesterol, and glycosolated haemoglobin (HbA1c) varied by menopausal status group, but blood pressure did not. Levels of total cholesterol and HbA1c increased across the natural menopause transition, before and after adjustment for body mass index, smoking and lifetime socio-economic circumstances. After adjustment for confounders, levels of risk factors for hysterectomised women were similar to those of naturally postmenopausal women. Women on hormone replacement therapy had lower levels of total and low density lipoprotein cholesterol, HbA1c, and were less obese than postmenopausal women. The lower obesity levels were partly due to these women already being less obese at age 43 years. CONCLUSIONS: This study showed that naturally postmenopausal or hysterectomised women had higher levels of metabolic risk factors compared with premenopausal or perimenopausal women of the same age. The long term stability of these differences and their translation into variations in incidence of cardiovascular disease remain to be seen. The lower levels of metabolic risk factors for women on hormone replacement therapy may protect against future cardiovascular disease or may be overwhelmed by other adverse, and as yet unknown, effects of hormone replacement therapy. SN - 1470-0328 UR - https://www.unboundmedicine.com/medline/citation/15777448/Cardiovascular_risk_at_age_53_years_in_relation_to_the_menopause_transition_and_use_of_hormone_replacement_therapy:_a_prospective_British_birth_cohort_study_ L2 - https://doi.org/10.1111/j.1471-0528.2005.00416.x DB - PRIME DP - Unbound Medicine ER -