Tags

Type your tag names separated by a space and hit enter

[Associations between genetic polymorphisms of glutathione S-transferase M1 and T1, smoking and susceptibility to colorectal cancer: a case-control study].
Zhonghua Zhong Liu Za Zhi. 2004 Nov; 26(11):645-8.ZZ

Abstract

OBJECTIVE

To evaluate the associations between genetic polymorphisms of glutathione S-transferase M1 and T1 (GSTM1 and GSTT1), smoking and susceptibility to colorectal cancer.

METHODS

A case-control study of 126 patients and 343 healthy controls was conducted to investigate the role of GSTM1 and GSTT1 polymorphisms in colorectal cancer. Genotypes of GSTM1 and GSTT1 polymorphisms were analyzed by multiplex allele-specific polymerase chain reaction (PCR).

RESULTS

The frequencies of GSTM1 null and GSTT1 null genotypes were 55.5% and 20.4%, respectively. After adjustment for age and sex, among those with GSTT1 null genotype, the GSTM1 null genotype had a significant increased risk of rectal cancers compared to GSTM1 non-null genotype (OR=9.74, 95% CI, 1.13 - 83.85). A 2.22-fold risk of colon cancers was associated with GSTM1 null genotype compared to GSTM1 non-null genotype among current smokers (P >0.05). Individuals with GSTT1 null genotype and currently smoking had a significant risk of colon cancers (OR = 4.55, 95% CI, 1.14 - 18.17), and rectal cancers (OR = 4.60, 95% CI, 1.11 - 19.11).

CONCLUSION

This study suggests that certain null GSTM1 and GSTT1 genotypes may be associated with an elevated risk of colorectal cancer which may be modified by interaction of the two genetic polymorphisms and cigarette smoking.

Authors+Show Affiliations

Department of Epidemiology and Statistics, School of Medicine, Zhejiang University, Hangzhou 310031, China. E-mail: CK@zjuem.zju.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15777499

Citation

Chen, Kun, et al. "[Associations Between Genetic Polymorphisms of Glutathione S-transferase M1 and T1, Smoking and Susceptibility to Colorectal Cancer: a Case-control Study]." Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], vol. 26, no. 11, 2004, pp. 645-8.
Chen K, Jiang QT, Ma XY, et al. [Associations between genetic polymorphisms of glutathione S-transferase M1 and T1, smoking and susceptibility to colorectal cancer: a case-control study]. Zhonghua Zhong Liu Za Zhi. 2004;26(11):645-8.
Chen, K., Jiang, Q. T., Ma, X. Y., Yao, K. Y., Leng, S. G., Yu, W. P., & Zhou, H. G. (2004). [Associations between genetic polymorphisms of glutathione S-transferase M1 and T1, smoking and susceptibility to colorectal cancer: a case-control study]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], 26(11), 645-8.
Chen K, et al. [Associations Between Genetic Polymorphisms of Glutathione S-transferase M1 and T1, Smoking and Susceptibility to Colorectal Cancer: a Case-control Study]. Zhonghua Zhong Liu Za Zhi. 2004;26(11):645-8. PubMed PMID: 15777499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Associations between genetic polymorphisms of glutathione S-transferase M1 and T1, smoking and susceptibility to colorectal cancer: a case-control study]. AU - Chen,Kun, AU - Jiang,Qin-ting, AU - Ma,Xin-yuan, AU - Yao,Kai-yan, AU - Leng,Shu-guang, AU - Yu,Wei-ping, AU - Zhou,Hai-guang, PY - 2005/3/22/pubmed PY - 2005/10/12/medline PY - 2005/3/22/entrez SP - 645 EP - 8 JF - Zhonghua zhong liu za zhi [Chinese journal of oncology] JO - Zhonghua Zhong Liu Za Zhi VL - 26 IS - 11 N2 - OBJECTIVE: To evaluate the associations between genetic polymorphisms of glutathione S-transferase M1 and T1 (GSTM1 and GSTT1), smoking and susceptibility to colorectal cancer. METHODS: A case-control study of 126 patients and 343 healthy controls was conducted to investigate the role of GSTM1 and GSTT1 polymorphisms in colorectal cancer. Genotypes of GSTM1 and GSTT1 polymorphisms were analyzed by multiplex allele-specific polymerase chain reaction (PCR). RESULTS: The frequencies of GSTM1 null and GSTT1 null genotypes were 55.5% and 20.4%, respectively. After adjustment for age and sex, among those with GSTT1 null genotype, the GSTM1 null genotype had a significant increased risk of rectal cancers compared to GSTM1 non-null genotype (OR=9.74, 95% CI, 1.13 - 83.85). A 2.22-fold risk of colon cancers was associated with GSTM1 null genotype compared to GSTM1 non-null genotype among current smokers (P >0.05). Individuals with GSTT1 null genotype and currently smoking had a significant risk of colon cancers (OR = 4.55, 95% CI, 1.14 - 18.17), and rectal cancers (OR = 4.60, 95% CI, 1.11 - 19.11). CONCLUSION: This study suggests that certain null GSTM1 and GSTT1 genotypes may be associated with an elevated risk of colorectal cancer which may be modified by interaction of the two genetic polymorphisms and cigarette smoking. SN - 0253-3766 UR - https://www.unboundmedicine.com/medline/citation/15777499/[Associations_between_genetic_polymorphisms_of_glutathione_S_transferase_M1_and_T1_smoking_and_susceptibility_to_colorectal_cancer:_a_case_control_study]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0253-3766&year=2004&vol=26&issue=11&fpage=645 DB - PRIME DP - Unbound Medicine ER -