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Bran extracts from pigmented rice seeds inhibit tumor promotion in lymphoblastoid B cells by phorbol ester.
Food Chem Toxicol. 2005 May; 43(5):741-5.FC

Abstract

Using flow cytometry, we quantitatively evaluated anti-tumor-promoting activity of rice bran extracts by measuring inhibition of Epstein-Barr virus early-antigen activation (EBV-EA) induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). This assay measures anti-tumor-promoting activity and cytotoxicity of target substances using the same batch of cells. Using this short-term procedure, we have determined the anti-tumor-promoting activity of 70% ethanol-water extracts of bran (outer layer) from seeds of five pigmented rice cultivars: Jumlalocal-1, DZ 78, Elwee, LK1-3-6-12-1-1, and LK1A-2-12-1-1. The results show that, compared to an extract from the non-pigmented white cooking rice variety Chuchung, the extracts from the pigmented varieties strongly inhibited phorbol ester-induced tumor promotion in marmoset lymphoblastoid cells B95-8 in vitro. These findings may facilitate development and use of new health-promoting rice varieties.

Authors+Show Affiliations

Department of Biological Science, Ajou University, Suwon 443-749, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15778014

Citation

Nam, S H., et al. "Bran Extracts From Pigmented Rice Seeds Inhibit Tumor Promotion in Lymphoblastoid B Cells By Phorbol Ester." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 43, no. 5, 2005, pp. 741-5.
Nam SH, Choi SP, Kang MY, et al. Bran extracts from pigmented rice seeds inhibit tumor promotion in lymphoblastoid B cells by phorbol ester. Food Chem Toxicol. 2005;43(5):741-5.
Nam, S. H., Choi, S. P., Kang, M. Y., Koh, H. J., Kozukue, N., & Friedman, M. (2005). Bran extracts from pigmented rice seeds inhibit tumor promotion in lymphoblastoid B cells by phorbol ester. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 43(5), 741-5.
Nam SH, et al. Bran Extracts From Pigmented Rice Seeds Inhibit Tumor Promotion in Lymphoblastoid B Cells By Phorbol Ester. Food Chem Toxicol. 2005;43(5):741-5. PubMed PMID: 15778014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bran extracts from pigmented rice seeds inhibit tumor promotion in lymphoblastoid B cells by phorbol ester. AU - Nam,S H, AU - Choi,S P, AU - Kang,M Y, AU - Koh,H J, AU - Kozukue,N, AU - Friedman,Mendel, PY - 2004/10/12/received PY - 2005/01/19/revised PY - 2005/01/25/accepted PY - 2005/3/22/pubmed PY - 2005/4/26/medline PY - 2005/3/22/entrez SP - 741 EP - 5 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 43 IS - 5 N2 - Using flow cytometry, we quantitatively evaluated anti-tumor-promoting activity of rice bran extracts by measuring inhibition of Epstein-Barr virus early-antigen activation (EBV-EA) induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). This assay measures anti-tumor-promoting activity and cytotoxicity of target substances using the same batch of cells. Using this short-term procedure, we have determined the anti-tumor-promoting activity of 70% ethanol-water extracts of bran (outer layer) from seeds of five pigmented rice cultivars: Jumlalocal-1, DZ 78, Elwee, LK1-3-6-12-1-1, and LK1A-2-12-1-1. The results show that, compared to an extract from the non-pigmented white cooking rice variety Chuchung, the extracts from the pigmented varieties strongly inhibited phorbol ester-induced tumor promotion in marmoset lymphoblastoid cells B95-8 in vitro. These findings may facilitate development and use of new health-promoting rice varieties. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/15778014/Bran_extracts_from_pigmented_rice_seeds_inhibit_tumor_promotion_in_lymphoblastoid_B_cells_by_phorbol_ester_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(05)00046-3 DB - PRIME DP - Unbound Medicine ER -