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Inflammatory myofibroblastic tumor of the posterior mediastinum: an older adult case with anaplastic lymphoma kinase abnormalities determined using immunohistochemistry and fluorescence in situ hybridization.
Virchows Arch 2005; 446(4):451-5VA

Abstract

Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm that usually occurs in children and young adults. Anaplastic lymphoma kinase (ALK) abnormalities in IMT, determined using immunohistochemistry and/or molecular genetic studies, including fluorescence in situ hybridization (FISH), have almost been limited to children and young adults. In elderly cases of IMT, these ALK abnormalities are very rare. We report on a case of IMT arising in the posterior mediastinum of a 59-year-old Japanese man that showed ALK abnormalities determined using immunohistochemistry and FISH, suggesting the neoplastic nature of a subset of IMTs in older patients similar to those in younger ones and the presence of an additional mechanism(s) that allows them to start to grow late.

Authors+Show Affiliations

Department of Pathology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka , Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15778844

Citation

Makimoto, Yoshifumi, et al. "Inflammatory Myofibroblastic Tumor of the Posterior Mediastinum: an Older Adult Case With Anaplastic Lymphoma Kinase Abnormalities Determined Using Immunohistochemistry and Fluorescence in Situ Hybridization." Virchows Archiv : an International Journal of Pathology, vol. 446, no. 4, 2005, pp. 451-5.
Makimoto Y, Nabeshima K, Iwasaki H, et al. Inflammatory myofibroblastic tumor of the posterior mediastinum: an older adult case with anaplastic lymphoma kinase abnormalities determined using immunohistochemistry and fluorescence in situ hybridization. Virchows Arch. 2005;446(4):451-5.
Makimoto, Y., Nabeshima, K., Iwasaki, H., Ishiguro, A., Miyoshi, T., Shiraishi, T., ... Shirakusa, T. (2005). Inflammatory myofibroblastic tumor of the posterior mediastinum: an older adult case with anaplastic lymphoma kinase abnormalities determined using immunohistochemistry and fluorescence in situ hybridization. Virchows Archiv : an International Journal of Pathology, 446(4), pp. 451-5.
Makimoto Y, et al. Inflammatory Myofibroblastic Tumor of the Posterior Mediastinum: an Older Adult Case With Anaplastic Lymphoma Kinase Abnormalities Determined Using Immunohistochemistry and Fluorescence in Situ Hybridization. Virchows Arch. 2005;446(4):451-5. PubMed PMID: 15778844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory myofibroblastic tumor of the posterior mediastinum: an older adult case with anaplastic lymphoma kinase abnormalities determined using immunohistochemistry and fluorescence in situ hybridization. AU - Makimoto,Yoshifumi, AU - Nabeshima,Kazuki, AU - Iwasaki,Hiroshi, AU - Ishiguro,Akiko, AU - Miyoshi,Tatsu, AU - Shiraishi,Takeshi, AU - Iwasaki,Akinori, AU - Shirakusa,Takayuki, Y1 - 2005/03/19/ PY - 2004/08/23/received PY - 2004/10/30/accepted PY - 2005/3/22/pubmed PY - 2005/6/29/medline PY - 2005/3/22/entrez SP - 451 EP - 5 JF - Virchows Archiv : an international journal of pathology JO - Virchows Arch. VL - 446 IS - 4 N2 - Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm that usually occurs in children and young adults. Anaplastic lymphoma kinase (ALK) abnormalities in IMT, determined using immunohistochemistry and/or molecular genetic studies, including fluorescence in situ hybridization (FISH), have almost been limited to children and young adults. In elderly cases of IMT, these ALK abnormalities are very rare. We report on a case of IMT arising in the posterior mediastinum of a 59-year-old Japanese man that showed ALK abnormalities determined using immunohistochemistry and FISH, suggesting the neoplastic nature of a subset of IMTs in older patients similar to those in younger ones and the presence of an additional mechanism(s) that allows them to start to grow late. SN - 0945-6317 UR - https://www.unboundmedicine.com/medline/citation/15778844/Inflammatory_myofibroblastic_tumor_of_the_posterior_mediastinum:_an_older_adult_case_with_anaplastic_lymphoma_kinase_abnormalities_determined_using_immunohistochemistry_and_fluorescence_in_situ_hybridization_ L2 - https://dx.doi.org/10.1007/s00428-004-1170-6 DB - PRIME DP - Unbound Medicine ER -