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Sex hormones and cardiovascular risk.
Hum Reprod. 1992 Feb; 7(2):162-7.HR

Abstract

Inspection of the age-incidence curve of ischaemic heart disease in both sexes shows an increase in slope for women around the menopause, approaching that of men at older ages. Although the increase is likely to be related to the menopause, epidemiological evidence is not defined. Likewise, there is some suggestion that reproductive factors may be related to the subsequent risk of cardiovascular diseases, since a few studies found an elevated risk in women with an earlier first birth. In terms of prevention and public health considerations, treatments via exogenous hormones are, however, much more important. A systematic overview of the available epidemiological evidence indicates that oestrogen replacement treatment is protective against ischaemic heart disease. The overall relative risks based on 18 studies and greater than 3300 cases was 0.81, with a narrow 95% confidence interval (0.76-0.85), thus suggesting a protective effect of 15-25%. This protection has a plausible biological interpretation in terms of increased high density lipoprotein (HDL) levels. The serum lipoprotein pattern can be unfavourably influenced by progestin supplementation. With reference to oral contraceptives, the relative risk for cardiovascular mortality was increased about twofold in current users. There appears now to be convincing evidence that the elevated risk is restricted to current users.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Istituto di Richerche Farmacologiche Mario Negri, Milan, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

1577926

Citation

La Vecchia, C. "Sex Hormones and Cardiovascular Risk." Human Reproduction (Oxford, England), vol. 7, no. 2, 1992, pp. 162-7.
La Vecchia C. Sex hormones and cardiovascular risk. Hum Reprod. 1992;7(2):162-7.
La Vecchia, C. (1992). Sex hormones and cardiovascular risk. Human Reproduction (Oxford, England), 7(2), 162-7.
La Vecchia C. Sex Hormones and Cardiovascular Risk. Hum Reprod. 1992;7(2):162-7. PubMed PMID: 1577926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex hormones and cardiovascular risk. A1 - La Vecchia,C, PY - 1992/2/1/pubmed PY - 1992/2/1/medline PY - 1992/2/1/entrez KW - Biology KW - Breast Cancer KW - Cancer KW - Clinical Research KW - Cohort Analysis KW - Contraception KW - Contraceptive Methods--side effects KW - Diseases KW - Endocrine System KW - Estrogens KW - Family Planning KW - Heart Diseases KW - Hormones KW - Literature Review KW - Menopause KW - Neoplasms KW - Oral Contraceptives--side effects KW - Physiology KW - Reproduction KW - Research Methodology KW - Risk Factors KW - Treatment SP - 162 EP - 7 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 7 IS - 2 N2 - Inspection of the age-incidence curve of ischaemic heart disease in both sexes shows an increase in slope for women around the menopause, approaching that of men at older ages. Although the increase is likely to be related to the menopause, epidemiological evidence is not defined. Likewise, there is some suggestion that reproductive factors may be related to the subsequent risk of cardiovascular diseases, since a few studies found an elevated risk in women with an earlier first birth. In terms of prevention and public health considerations, treatments via exogenous hormones are, however, much more important. A systematic overview of the available epidemiological evidence indicates that oestrogen replacement treatment is protective against ischaemic heart disease. The overall relative risks based on 18 studies and greater than 3300 cases was 0.81, with a narrow 95% confidence interval (0.76-0.85), thus suggesting a protective effect of 15-25%. This protection has a plausible biological interpretation in terms of increased high density lipoprotein (HDL) levels. The serum lipoprotein pattern can be unfavourably influenced by progestin supplementation. With reference to oral contraceptives, the relative risk for cardiovascular mortality was increased about twofold in current users. There appears now to be convincing evidence that the elevated risk is restricted to current users.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/1577926/Sex_hormones_and_cardiovascular_risk_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/oxfordjournals.humrep.a137610 DB - PRIME DP - Unbound Medicine ER -