Tags

Type your tag names separated by a space and hit enter

SEN virus infection influences the pathological findings in liver but does not affect the incidence of hepatocellular carcinoma in patients with chronic hepatitis C and liver cirrhosis.
Liver Int 2005; 25(2):226-35LI

Abstract

BACKGROUND/AIMS

This investigation compared the histological findings in the livers of chronic hepatitis C patients who were or were not co-infected with SEN virus (SEN-V) to determine the histological and clinical characteristics of SEN-V infection in Japan.

METHODS

Three hundred and ninety-two patients with hepatitis C virus-associated chronic hepatitis (CH) or liver cirrhosis (LC) were included in the study. Serum samples were tested for the presence of SEN-V DNA by nested polymerase chain reaction. The liver biopsy specimen of each patient was examined and scores were assigned to indicate the severity of each of the following features: inflammatory cell infiltration in the periportal, parenchymal, and portal areas; F stage; portal sclerotic change; perivenular fibrosis; pericellular fibrosis; damage to the bile ducts; steatosis and irregular regeneration of hepatocytes (IR).

RESULTS

Of the 473 patients, 194 (41.0%) were positive for SEN-V DNA. The rate of progression of F stage correlated with SEN-V DNA positivity. The blood biochemical parameters did not differ significantly between the SEN-V DNA-positive and -negative patients. The histological features of the livers of SEN-V DNA-positive patients included more severe parenchymal inflammatory cell infiltration and more IR. In particular, among those at the F2, F3 and F4 stages, the degree of IR of the SEN-V DNA-positive patients was significantly greater than that of the SEN-V DNA-negative patients. The cumulative probability of hepatocellular carcinoma (HCC) incidence and survival rate did not differ between the SEN-V DNA-positive and-negative patients.

CONCLUSIONS

SEN-V co-infection may influence the histopathological features of the livers of patients with type C CH and LC but does not affect the outcome of patients with type C chronic liver disease.

Authors+Show Affiliations

Third Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi kamimachi, Itabashiku, Tokyo 173-8610, Japan. moriyama@med.nihon-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15780043

Citation

Moriyama, Mitsuhiko, et al. "SEN Virus Infection Influences the Pathological Findings in Liver but Does Not Affect the Incidence of Hepatocellular Carcinoma in Patients With Chronic Hepatitis C and Liver Cirrhosis." Liver International : Official Journal of the International Association for the Study of the Liver, vol. 25, no. 2, 2005, pp. 226-35.
Moriyama M, Mikuni M, Matsumura H, et al. SEN virus infection influences the pathological findings in liver but does not affect the incidence of hepatocellular carcinoma in patients with chronic hepatitis C and liver cirrhosis. Liver Int. 2005;25(2):226-35.
Moriyama, M., Mikuni, M., Matsumura, H., Nakamura, H., Oshiro, S., Aoki, H., ... Arakawa, Y. (2005). SEN virus infection influences the pathological findings in liver but does not affect the incidence of hepatocellular carcinoma in patients with chronic hepatitis C and liver cirrhosis. Liver International : Official Journal of the International Association for the Study of the Liver, 25(2), pp. 226-35.
Moriyama M, et al. SEN Virus Infection Influences the Pathological Findings in Liver but Does Not Affect the Incidence of Hepatocellular Carcinoma in Patients With Chronic Hepatitis C and Liver Cirrhosis. Liver Int. 2005;25(2):226-35. PubMed PMID: 15780043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SEN virus infection influences the pathological findings in liver but does not affect the incidence of hepatocellular carcinoma in patients with chronic hepatitis C and liver cirrhosis. AU - Moriyama,Mitsuhiko, AU - Mikuni,Morio, AU - Matsumura,Hiroshi, AU - Nakamura,Hitomi, AU - Oshiro,Shyu, AU - Aoki,Hiroshi, AU - Shimizu,Toshihiro, AU - Yamagami,Hiroaki, AU - Shioda,Atsuo, AU - Kaneko,Miki, AU - Tanaka,Naohide, AU - Arakawa,Yasuyuki, PY - 2005/3/23/pubmed PY - 2005/7/6/medline PY - 2005/3/23/entrez SP - 226 EP - 35 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int. VL - 25 IS - 2 N2 - BACKGROUND/AIMS: This investigation compared the histological findings in the livers of chronic hepatitis C patients who were or were not co-infected with SEN virus (SEN-V) to determine the histological and clinical characteristics of SEN-V infection in Japan. METHODS: Three hundred and ninety-two patients with hepatitis C virus-associated chronic hepatitis (CH) or liver cirrhosis (LC) were included in the study. Serum samples were tested for the presence of SEN-V DNA by nested polymerase chain reaction. The liver biopsy specimen of each patient was examined and scores were assigned to indicate the severity of each of the following features: inflammatory cell infiltration in the periportal, parenchymal, and portal areas; F stage; portal sclerotic change; perivenular fibrosis; pericellular fibrosis; damage to the bile ducts; steatosis and irregular regeneration of hepatocytes (IR). RESULTS: Of the 473 patients, 194 (41.0%) were positive for SEN-V DNA. The rate of progression of F stage correlated with SEN-V DNA positivity. The blood biochemical parameters did not differ significantly between the SEN-V DNA-positive and -negative patients. The histological features of the livers of SEN-V DNA-positive patients included more severe parenchymal inflammatory cell infiltration and more IR. In particular, among those at the F2, F3 and F4 stages, the degree of IR of the SEN-V DNA-positive patients was significantly greater than that of the SEN-V DNA-negative patients. The cumulative probability of hepatocellular carcinoma (HCC) incidence and survival rate did not differ between the SEN-V DNA-positive and-negative patients. CONCLUSIONS: SEN-V co-infection may influence the histopathological features of the livers of patients with type C CH and LC but does not affect the outcome of patients with type C chronic liver disease. SN - 1478-3223 UR - https://www.unboundmedicine.com/medline/citation/15780043/SEN_virus_infection_influences_the_pathological_findings_in_liver_but_does_not_affect_the_incidence_of_hepatocellular_carcinoma_in_patients_with_chronic_hepatitis_C_and_liver_cirrhosis_ L2 - https://doi.org/10.1111/j.1478-3231.2005.01076.x DB - PRIME DP - Unbound Medicine ER -