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Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever.
FEMS Immunol Med Microbiol. 2005 Apr 01; 44(1):43-50.FI

Abstract

To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-gamma levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.

Authors+Show Affiliations

Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15780577

Citation

Chen, Rong-Fu, et al. "Altered T Helper 1 Reaction but Not Increase of Virus Load in Patients With Dengue Hemorrhagic Fever." FEMS Immunology and Medical Microbiology, vol. 44, no. 1, 2005, pp. 43-50.
Chen RF, Liu JW, Yeh WT, et al. Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever. FEMS Immunol Med Microbiol. 2005;44(1):43-50.
Chen, R. F., Liu, J. W., Yeh, W. T., Wang, L., Chang, J. C., Yu, H. R., Cheng, J. T., & Yang, K. D. (2005). Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever. FEMS Immunology and Medical Microbiology, 44(1), 43-50.
Chen RF, et al. Altered T Helper 1 Reaction but Not Increase of Virus Load in Patients With Dengue Hemorrhagic Fever. FEMS Immunol Med Microbiol. 2005 Apr 1;44(1):43-50. PubMed PMID: 15780577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever. AU - Chen,Rong-Fu, AU - Liu,Jien-Wei, AU - Yeh,Wen-Ting, AU - Wang,Lin, AU - Chang,Jen-Chieh, AU - Yu,Hong-Ren, AU - Cheng,Jiin-Tsuey, AU - Yang,Kuender D, PY - 2004/10/13/received PY - 2004/11/24/revised PY - 2004/11/25/accepted PY - 2005/3/23/pubmed PY - 2005/6/14/medline PY - 2005/3/23/entrez SP - 43 EP - 50 JF - FEMS immunology and medical microbiology JO - FEMS Immunol Med Microbiol VL - 44 IS - 1 N2 - To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-gamma levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever. SN - 0928-8244 UR - https://www.unboundmedicine.com/medline/citation/15780577/Altered_T_helper_1_reaction_but_not_increase_of_virus_load_in_patients_with_dengue_hemorrhagic_fever_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0928-8244&date=2005&volume=44&issue=1&spage=43 DB - PRIME DP - Unbound Medicine ER -