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Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction.
J Am Coll Nutr 1992; 11(2):159-63JA

Abstract

This was a 4-week randomized placebo-controlled double-blind study to assess augmentation of open tricyclic antidepressant treatment with 10 mg each of vitamins B1, B2, and B6 in 14 geriatric inpatients with depression. The active vitamin group demonstrated significantly better B2 and B6 status on enzyme activity coefficients and trends toward greater improvement in scores on ratings of depression and congnitive function, as well as in serum nortriptyline levels compared with placebo-treated subjects (Ss). Without specific supplementation, B12 levels increased in Ss receiving B1/B2/B6 and decreased in placebo Ss. These findings offer preliminary support for further investigation of B complex vitamin augmentation in the treatment of geriatric depression.

Authors+Show Affiliations

Department of Psychiatry, Harvard Medical School.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

1578091

Citation

Bell, I R., et al. "Brief Communication. Vitamin B1, B2, and B6 Augmentation of Tricyclic Antidepressant Treatment in Geriatric Depression With Cognitive Dysfunction." Journal of the American College of Nutrition, vol. 11, no. 2, 1992, pp. 159-63.
Bell IR, Edman JS, Morrow FD, et al. Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction. J Am Coll Nutr. 1992;11(2):159-63.
Bell, I. R., Edman, J. S., Morrow, F. D., Marby, D. W., Perrone, G., Kayne, H. L., ... Cole, J. O. (1992). Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction. Journal of the American College of Nutrition, 11(2), pp. 159-63.
Bell IR, et al. Brief Communication. Vitamin B1, B2, and B6 Augmentation of Tricyclic Antidepressant Treatment in Geriatric Depression With Cognitive Dysfunction. J Am Coll Nutr. 1992;11(2):159-63. PubMed PMID: 1578091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction. AU - Bell,I R, AU - Edman,J S, AU - Morrow,F D, AU - Marby,D W, AU - Perrone,G, AU - Kayne,H L, AU - Greenwald,M, AU - Cole,J O, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 159 EP - 63 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 11 IS - 2 N2 - This was a 4-week randomized placebo-controlled double-blind study to assess augmentation of open tricyclic antidepressant treatment with 10 mg each of vitamins B1, B2, and B6 in 14 geriatric inpatients with depression. The active vitamin group demonstrated significantly better B2 and B6 status on enzyme activity coefficients and trends toward greater improvement in scores on ratings of depression and congnitive function, as well as in serum nortriptyline levels compared with placebo-treated subjects (Ss). Without specific supplementation, B12 levels increased in Ss receiving B1/B2/B6 and decreased in placebo Ss. These findings offer preliminary support for further investigation of B complex vitamin augmentation in the treatment of geriatric depression. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/1578091/full_citation L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -