Prime

Type your tag names separated by a space and hit enter

Determinants of plasma acid-base balance.

Abstract

An advanced understanding of acid-base physiology is central to the practice of critical care medicine. Intensivists spend much of their time managing problems that are related to fluids, electrolytes, and blood pH. Recent advances in the understanding of acid-base physiology occurred as the result of the application of basic physical-chemical principles of aqueous solutions to blood plasma. This analysis revealed three independent variables that regulate pH in blood plasma: carbon dioxide, relative electrolyte concentrations, and total weak acid concentrations. All changes in blood pH, in health and in disease, occur through changes in these three variables. This article reviews the physical-chemical approach to acid-base balance and considers clinical implications for these findings.

Links

  • Publisher Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 608 Scaife Hall, Pittsburgh, PA 15213-2582, USA. kellumja@ccm.upmc.edu

    Source

    Critical care clinics 21:2 2005 Apr pg 329-46

    MeSH

    Acid-Base Equilibrium
    Acid-Base Imbalance
    Carbon Dioxide
    Electrolytes
    Humans
    Hypoalbuminemia

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15781166