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Excess of serum copper not related to ceruloplasmin in Alzheimer disease.
Neurology. 2005 Mar 22; 64(6):1040-6.Neur

Abstract

OBJECTIVE

To assess the role of serum copper in relation to ceruloplasmin and other peripheral markers of inflammation in Alzheimer disease (AD).

METHODS

The authors studied serum levels of copper, ceruloplasmin, and transferrin, as well as total peroxides, antioxidants, and other peripheral markers of inflammation in 47 patients with AD, 24 patients with vascular dementia (VaD), and 44 healthy controls. Biochemical variables were related to the patients' and controls' clinical status.

RESULTS

The authors found that copper (p < 0.001), peroxides (p = 0.026), and ceruloplasmin (p = 0.052) were increased and TRAP was decreased (p = 0.006) in patients with AD, while no other markers of inflammation were altered. The calculation of the ratio between copper and ceruloplasmin suggested the presence in the serum of AD patients, but not of VaD or normal controls, of a large pool of non-ceruloplasmin-bound copper.

CONCLUSIONS

Changes in the distribution of the serum copper components, consisting of an increase of a copper fraction not explained by ceruloplasmin, seem to be characteristic of Alzheimer disease and may be implicated in the pathogenesis of the disease.

Authors+Show Affiliations

Squitti R
Department of Neuroscience, AFaR-Osp. Fatebenefratelli, 00186, Rome, Italy. rosanna.squitti@afar.it
Pasqualetti P
No affiliation info available
Dal Forno G
No affiliation info available
Moffa F
No affiliation info available
Cassetta E
No affiliation info available
Lupoi D
No affiliation info available
Vernieri F
No affiliation info available
Rossi L
No affiliation info available
Baldassini M
No affiliation info available
Rossini PM
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseAntioxidantsBiomarkersCeruloplasminCopperEncephalitisFemaleHumansInflammation MediatorsMaleMiddle AgedPeroxidesPredictive Value of TestsTransferrin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15781823

Citation

Squitti, R, et al. "Excess of Serum Copper Not Related to Ceruloplasmin in Alzheimer Disease." Neurology, vol. 64, no. 6, 2005, pp. 1040-6.
Squitti R, Pasqualetti P, Dal Forno G, et al. Excess of serum copper not related to ceruloplasmin in Alzheimer disease. Neurology. 2005;64(6):1040-6.
Squitti, R., Pasqualetti, P., Dal Forno, G., Moffa, F., Cassetta, E., Lupoi, D., Vernieri, F., Rossi, L., Baldassini, M., & Rossini, P. M. (2005). Excess of serum copper not related to ceruloplasmin in Alzheimer disease. Neurology, 64(6), 1040-6.
Squitti R, et al. Excess of Serum Copper Not Related to Ceruloplasmin in Alzheimer Disease. Neurology. 2005 Mar 22;64(6):1040-6. PubMed PMID: 15781823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Excess of serum copper not related to ceruloplasmin in Alzheimer disease. AU - Squitti,R, AU - Pasqualetti,P, AU - Dal Forno,G, AU - Moffa,F, AU - Cassetta,E, AU - Lupoi,D, AU - Vernieri,F, AU - Rossi,L, AU - Baldassini,M, AU - Rossini,P M, PY - 2005/3/23/pubmed PY - 2006/2/24/medline PY - 2005/3/23/entrez SP - 1040 EP - 6 JF - Neurology JO - Neurology VL - 64 IS - 6 N2 - OBJECTIVE: To assess the role of serum copper in relation to ceruloplasmin and other peripheral markers of inflammation in Alzheimer disease (AD). METHODS: The authors studied serum levels of copper, ceruloplasmin, and transferrin, as well as total peroxides, antioxidants, and other peripheral markers of inflammation in 47 patients with AD, 24 patients with vascular dementia (VaD), and 44 healthy controls. Biochemical variables were related to the patients' and controls' clinical status. RESULTS: The authors found that copper (p < 0.001), peroxides (p = 0.026), and ceruloplasmin (p = 0.052) were increased and TRAP was decreased (p = 0.006) in patients with AD, while no other markers of inflammation were altered. The calculation of the ratio between copper and ceruloplasmin suggested the presence in the serum of AD patients, but not of VaD or normal controls, of a large pool of non-ceruloplasmin-bound copper. CONCLUSIONS: Changes in the distribution of the serum copper components, consisting of an increase of a copper fraction not explained by ceruloplasmin, seem to be characteristic of Alzheimer disease and may be implicated in the pathogenesis of the disease. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15781823/Excess_of_serum_copper_not_related_to_ceruloplasmin_in_Alzheimer_disease_ DB - PRIME DP - Unbound Medicine ER -