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Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study.
Am J Epidemiol. 2005 Apr 01; 161(7):639-51.AJ

Abstract

Physical activity may help preserve cognitive function and decrease dementia risk, but epidemiologic findings are inconsistent. The authors conducted a prospective study to determine the association between physical activity and risk of dementia, Alzheimer's disease, and vascular dementia. The US study population comprised 3,375 men and women aged 65 years or older, free of dementia at baseline, who participated in the Cardiovascular Health Cognition Study in 1992-2000. Leisure-time energy expenditure and an activity index reflecting number of different physical activities were calculated. Analyses were based on Cox proportional hazards models. There were 480 incident cases of dementia over an average of 5.4 years of follow-up. After multivariate adjustment, participants in the highest quartile of physical energy expenditure had a relative risk of dementia of 0.85 (95% confidence interval: 0.61, 1.19) compared with those in the lowest quartile, and participants engaging in >or=4 activities had a relative risk of dementia of 0.51 (95% confidence interval: 0.33, 0.79) compared with those engaging in 0-1 activity. These associations were more marked in apolipoprotein E genotype (APOE) epsilon4 allele noncarriers but were absent in carriers. A similar pattern was observed for Alzheimer's disease and vascular dementia. Mechanisms to explain the observed relations deserve further study.

Authors+Show Affiliations

Podewils LJ
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Guallar E
No affiliation info available
Kuller LH
No affiliation info available
Fried LP
No affiliation info available
Lopez OL
No affiliation info available
Carlson M
No affiliation info available
Lyketsos CG
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseApolipoproteins EDementiaDementia, VascularFemaleGenotypeHumansMaleMotor ActivityProportional Hazards ModelsProspective StudiesRisk FactorsUnited States

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15781953

Citation

Podewils, Laura Jean, et al. "Physical Activity, APOE Genotype, and Dementia Risk: Findings From the Cardiovascular Health Cognition Study." American Journal of Epidemiology, vol. 161, no. 7, 2005, pp. 639-51.
Podewils LJ, Guallar E, Kuller LH, et al. Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. Am J Epidemiol. 2005;161(7):639-51.
Podewils, L. J., Guallar, E., Kuller, L. H., Fried, L. P., Lopez, O. L., Carlson, M., & Lyketsos, C. G. (2005). Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. American Journal of Epidemiology, 161(7), 639-51.
Podewils LJ, et al. Physical Activity, APOE Genotype, and Dementia Risk: Findings From the Cardiovascular Health Cognition Study. Am J Epidemiol. 2005 Apr 1;161(7):639-51. PubMed PMID: 15781953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. AU - Podewils,Laura Jean, AU - Guallar,Eliseo, AU - Kuller,Lewis H, AU - Fried,Linda P, AU - Lopez,Oscar L, AU - Carlson,Michelle, AU - Lyketsos,Constantine G, PY - 2005/3/23/pubmed PY - 2005/5/13/medline PY - 2005/3/23/entrez SP - 639 EP - 51 JF - American journal of epidemiology JO - Am J Epidemiol VL - 161 IS - 7 N2 - Physical activity may help preserve cognitive function and decrease dementia risk, but epidemiologic findings are inconsistent. The authors conducted a prospective study to determine the association between physical activity and risk of dementia, Alzheimer's disease, and vascular dementia. The US study population comprised 3,375 men and women aged 65 years or older, free of dementia at baseline, who participated in the Cardiovascular Health Cognition Study in 1992-2000. Leisure-time energy expenditure and an activity index reflecting number of different physical activities were calculated. Analyses were based on Cox proportional hazards models. There were 480 incident cases of dementia over an average of 5.4 years of follow-up. After multivariate adjustment, participants in the highest quartile of physical energy expenditure had a relative risk of dementia of 0.85 (95% confidence interval: 0.61, 1.19) compared with those in the lowest quartile, and participants engaging in >or=4 activities had a relative risk of dementia of 0.51 (95% confidence interval: 0.33, 0.79) compared with those engaging in 0-1 activity. These associations were more marked in apolipoprotein E genotype (APOE) epsilon4 allele noncarriers but were absent in carriers. A similar pattern was observed for Alzheimer's disease and vascular dementia. Mechanisms to explain the observed relations deserve further study. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15781953/Physical_activity_APOE_genotype_and_dementia_risk:_findings_from_the_Cardiovascular_Health_Cognition_Study_ DB - PRIME DP - Unbound Medicine ER -