Tags

Type your tag names separated by a space and hit enter

Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study.

Abstract

Physical activity may help preserve cognitive function and decrease dementia risk, but epidemiologic findings are inconsistent. The authors conducted a prospective study to determine the association between physical activity and risk of dementia, Alzheimer's disease, and vascular dementia. The US study population comprised 3,375 men and women aged 65 years or older, free of dementia at baseline, who participated in the Cardiovascular Health Cognition Study in 1992-2000. Leisure-time energy expenditure and an activity index reflecting number of different physical activities were calculated. Analyses were based on Cox proportional hazards models. There were 480 incident cases of dementia over an average of 5.4 years of follow-up. After multivariate adjustment, participants in the highest quartile of physical energy expenditure had a relative risk of dementia of 0.85 (95% confidence interval: 0.61, 1.19) compared with those in the lowest quartile, and participants engaging in >or=4 activities had a relative risk of dementia of 0.51 (95% confidence interval: 0.33, 0.79) compared with those engaging in 0-1 activity. These associations were more marked in apolipoprotein E genotype (APOE) epsilon4 allele noncarriers but were absent in carriers. A similar pattern was observed for Alzheimer's disease and vascular dementia. Mechanisms to explain the observed relations deserve further study.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

    , , , , ,

    Source

    American journal of epidemiology 161:7 2005 Apr 01 pg 639-51

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Apolipoproteins E
    Dementia
    Dementia, Vascular
    Female
    Genotype
    Humans
    Male
    Motor Activity
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15781953

    Citation

    Podewils, Laura Jean, et al. "Physical Activity, APOE Genotype, and Dementia Risk: Findings From the Cardiovascular Health Cognition Study." American Journal of Epidemiology, vol. 161, no. 7, 2005, pp. 639-51.
    Podewils LJ, Guallar E, Kuller LH, et al. Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. Am J Epidemiol. 2005;161(7):639-51.
    Podewils, L. J., Guallar, E., Kuller, L. H., Fried, L. P., Lopez, O. L., Carlson, M., & Lyketsos, C. G. (2005). Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. American Journal of Epidemiology, 161(7), pp. 639-51.
    Podewils LJ, et al. Physical Activity, APOE Genotype, and Dementia Risk: Findings From the Cardiovascular Health Cognition Study. Am J Epidemiol. 2005 Apr 1;161(7):639-51. PubMed PMID: 15781953.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. AU - Podewils,Laura Jean, AU - Guallar,Eliseo, AU - Kuller,Lewis H, AU - Fried,Linda P, AU - Lopez,Oscar L, AU - Carlson,Michelle, AU - Lyketsos,Constantine G, PY - 2005/3/23/pubmed PY - 2005/5/13/medline PY - 2005/3/23/entrez SP - 639 EP - 51 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 161 IS - 7 N2 - Physical activity may help preserve cognitive function and decrease dementia risk, but epidemiologic findings are inconsistent. The authors conducted a prospective study to determine the association between physical activity and risk of dementia, Alzheimer's disease, and vascular dementia. The US study population comprised 3,375 men and women aged 65 years or older, free of dementia at baseline, who participated in the Cardiovascular Health Cognition Study in 1992-2000. Leisure-time energy expenditure and an activity index reflecting number of different physical activities were calculated. Analyses were based on Cox proportional hazards models. There were 480 incident cases of dementia over an average of 5.4 years of follow-up. After multivariate adjustment, participants in the highest quartile of physical energy expenditure had a relative risk of dementia of 0.85 (95% confidence interval: 0.61, 1.19) compared with those in the lowest quartile, and participants engaging in >or=4 activities had a relative risk of dementia of 0.51 (95% confidence interval: 0.33, 0.79) compared with those engaging in 0-1 activity. These associations were more marked in apolipoprotein E genotype (APOE) epsilon4 allele noncarriers but were absent in carriers. A similar pattern was observed for Alzheimer's disease and vascular dementia. Mechanisms to explain the observed relations deserve further study. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15781953/Physical_activity_APOE_genotype_and_dementia_risk:_findings_from_the_Cardiovascular_Health_Cognition_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi092 DB - PRIME DP - Unbound Medicine ER -