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Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study.

Abstract

The authors examined the associations of dietary fat and specific types of fat with risk of coronary heart disease (CHD) among 78,778 US women initially free of cardiovascular disease and diabetes in 1980. They documented 1,766 incident CHD cases (including 1,241 nonfatal myocardial infarctions and 525 CHD deaths) during 20 years of follow-up. Polyunsaturated fat intake was inversely associated with CHD risk (multivariate relative risk (RR) for the highest vs. the lowest quintile = 0.75, 95% confidence interval (CI): 0.60, 0.92; p(trend) = 0.004), whereas trans-fat intake was associated with an elevated risk of CHD (RR = 1.33, 95% CI: 1.07, 1.66; p(trend) = 0.01). The associations between intakes of polyunsaturated fat and trans-fat with CHD risk were most evident among women younger than age 65 years (for polyunsaturated fat, RR = 0.66, 95% CI: 0.50, 0.85; p(trend) = 0.002 and for trans-fat, RR = 1.50, 95% CI: 1.13, 2.00; p(trend) = 0.01). The inverse association between polyunsaturated fat intake and CHD risk was strongest among women whose body mass index was >or=25 kg/m(2). Findings continue to support an inverse relation between polyunsaturated fat intake and CHD risk, particularly among younger or overweight women. In addition, trans-fat intake was associated with increased risk of CHD, particularly for younger women.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.

    , , ,

    Source

    American journal of epidemiology 161:7 2005 Apr 01 pg 672-9

    MeSH

    Adult
    Coronary Disease
    Dietary Fats
    Female
    Follow-Up Studies
    Humans
    Incidence
    Middle Aged
    Nurses
    Proportional Hazards Models
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15781956

    Citation

    Oh, Kyungwon, et al. "Dietary Fat Intake and Risk of Coronary Heart Disease in Women: 20 Years of Follow-up of the Nurses' Health Study." American Journal of Epidemiology, vol. 161, no. 7, 2005, pp. 672-9.
    Oh K, Hu FB, Manson JE, et al. Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study. Am J Epidemiol. 2005;161(7):672-9.
    Oh, K., Hu, F. B., Manson, J. E., Stampfer, M. J., & Willett, W. C. (2005). Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study. American Journal of Epidemiology, 161(7), pp. 672-9.
    Oh K, et al. Dietary Fat Intake and Risk of Coronary Heart Disease in Women: 20 Years of Follow-up of the Nurses' Health Study. Am J Epidemiol. 2005 Apr 1;161(7):672-9. PubMed PMID: 15781956.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study. AU - Oh,Kyungwon, AU - Hu,Frank B, AU - Manson,JoAnn E, AU - Stampfer,Meir J, AU - Willett,Walter C, PY - 2005/3/23/pubmed PY - 2005/5/13/medline PY - 2005/3/23/entrez SP - 672 EP - 9 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 161 IS - 7 N2 - The authors examined the associations of dietary fat and specific types of fat with risk of coronary heart disease (CHD) among 78,778 US women initially free of cardiovascular disease and diabetes in 1980. They documented 1,766 incident CHD cases (including 1,241 nonfatal myocardial infarctions and 525 CHD deaths) during 20 years of follow-up. Polyunsaturated fat intake was inversely associated with CHD risk (multivariate relative risk (RR) for the highest vs. the lowest quintile = 0.75, 95% confidence interval (CI): 0.60, 0.92; p(trend) = 0.004), whereas trans-fat intake was associated with an elevated risk of CHD (RR = 1.33, 95% CI: 1.07, 1.66; p(trend) = 0.01). The associations between intakes of polyunsaturated fat and trans-fat with CHD risk were most evident among women younger than age 65 years (for polyunsaturated fat, RR = 0.66, 95% CI: 0.50, 0.85; p(trend) = 0.002 and for trans-fat, RR = 1.50, 95% CI: 1.13, 2.00; p(trend) = 0.01). The inverse association between polyunsaturated fat intake and CHD risk was strongest among women whose body mass index was >or=25 kg/m(2). Findings continue to support an inverse relation between polyunsaturated fat intake and CHD risk, particularly among younger or overweight women. In addition, trans-fat intake was associated with increased risk of CHD, particularly for younger women. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15781956/Dietary_fat_intake_and_risk_of_coronary_heart_disease_in_women:_20_years_of_follow_up_of_the_nurses'_health_study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi085 DB - PRIME DP - Unbound Medicine ER -