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Antiulcerogenic effect of Justicia prostrata Gamble.
Indian J Exp Biol. 2005 Feb; 43(2):181-6.IJ

Abstract

Antiulcerogenic effect of the alcoholic (ALJP) and aqueous (AQJP) extracts of the whole plant of Justicia prostrata was studied in aspirin+pylorus ligated rat models and analysed for gastric volume, ulcer index, free and total acidity. Biochemical parameters like total proteins, total hexoses, hexosamine, fucose and sialic acid were also estimated. Both extracts (ALJP and AQJP) significantly reduced both the gastric volume and the acidity of gastric juice. It also significantly promoted gastric mucus secretion by increasing total carbohydrates and decreasing the protein concentration in aspirin+ pylorus ligated rats. The results suggest that both the extracts (ALJP and AQJP) possess antiulcer activity, whereas AQJP is more effective when compared with ALJP in aspirin+pylorus ligated rat models. The results were compared with the standard drug Rantidine, a H2 receptor antagonist.

Authors+Show Affiliations

Sanmugapriya E
Department of Pharmacology & Environmental Toxicology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India.
Shanmugasundaram P
No affiliation info available
Venkataraman S
No affiliation info available

MeSH

AcanthaceaeAnimalsAnti-Ulcer AgentsAspirinDisease Models, AnimalDose-Response Relationship, DrugGastric Acidity DeterminationGastric JuiceGastric MucinsGastric MucosaLigationMalePlant ExtractsRatsRats, WistarStomach Ulcer

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15782821

Citation

Sanmugapriya, E, et al. "Antiulcerogenic Effect of Justicia Prostrata Gamble." Indian Journal of Experimental Biology, vol. 43, no. 2, 2005, pp. 181-6.
Sanmugapriya E, Shanmugasundaram P, Venkataraman S. Antiulcerogenic effect of Justicia prostrata Gamble. Indian J Exp Biol. 2005;43(2):181-6.
Sanmugapriya, E., Shanmugasundaram, P., & Venkataraman, S. (2005). Antiulcerogenic effect of Justicia prostrata Gamble. Indian Journal of Experimental Biology, 43(2), 181-6.
Sanmugapriya E, Shanmugasundaram P, Venkataraman S. Antiulcerogenic Effect of Justicia Prostrata Gamble. Indian J Exp Biol. 2005;43(2):181-6. PubMed PMID: 15782821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiulcerogenic effect of Justicia prostrata Gamble. AU - Sanmugapriya,E, AU - Shanmugasundaram,P, AU - Venkataraman,S, PY - 2005/3/24/pubmed PY - 2005/4/19/medline PY - 2005/3/24/entrez SP - 181 EP - 6 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 43 IS - 2 N2 - Antiulcerogenic effect of the alcoholic (ALJP) and aqueous (AQJP) extracts of the whole plant of Justicia prostrata was studied in aspirin+pylorus ligated rat models and analysed for gastric volume, ulcer index, free and total acidity. Biochemical parameters like total proteins, total hexoses, hexosamine, fucose and sialic acid were also estimated. Both extracts (ALJP and AQJP) significantly reduced both the gastric volume and the acidity of gastric juice. It also significantly promoted gastric mucus secretion by increasing total carbohydrates and decreasing the protein concentration in aspirin+ pylorus ligated rats. The results suggest that both the extracts (ALJP and AQJP) possess antiulcer activity, whereas AQJP is more effective when compared with ALJP in aspirin+pylorus ligated rat models. The results were compared with the standard drug Rantidine, a H2 receptor antagonist. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/15782821/Antiulcerogenic_effect_of_Justicia_prostrata_Gamble_ DB - PRIME DP - Unbound Medicine ER -