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Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asan-si, Korea.

Abstract

BACKGROUND AND AIMS

This study estimated the prevalence and clinical spectrum of gastroesophageal reflux disease (GERD) in Asan-si, Korea, as the prevalence is believed to be lower than in Western countries.

METHODS

A cross-sectional survey, using a reliable and valid questionnaire, was performed on randomly selected 2,240 Asan-si residents aged between 18 and 69 yr. All respondents were interviewed at their homes or offices by a team of interviewers.

RESULTS

Of the 1,902 eligible subjects, 1,417 (78.4%: male 762; female 655) were surveyed. The prevalence of heartburn occurring at least once a month, at least once a week, and at least twice a week was 4.71% (95% confidence interval (CI), 3.6-5.8), 2.0% (95% CI, 1.2-2.7), and 1.3% (95% CI, 0.7-1.9), respectively. The corresponding figures for acid regurgitation were 4.4% (95% CI, 3.3-5.5) and 2.0% (95% CI, 1.3-2.8), respectively. The prevalence of GERD, defined as heartburn and/or acid regurgitation experienced at least weekly, was 3.5% (95% CI, 2.6-4.5). No significant difference was detected between sexes. The prevalence of heartburn was associated with increasing age (p < 0.001). Nineteen percent of our population reported at least one of the atypical symptoms, for instance, chest pain, dysphagia, globus sensation, asthma, bronchitis, pneumonia, or hoarseness. The frequency of frequent GERD among subjects reporting any of the atypical symptoms was 12.6%, which was higher than that of the subjects without atypical symptoms. Patients with typical reflux symptoms were more common among those with atypical symptoms, compared to those without such symptoms (p < 0.001). Using a logistic regression model after adjusting for age and sex, typical reflux symptoms were associated with chest pain (odds ratio (OR), 9.3; 95% CI, 5.9-14.7), dysphagia (OR, 6.4; 95% CI, 2.8-14.7), globus sensation (OR, 3.9; 95% CI, 1.5-9.7), hoarseness (OR, 4.3; 95% CI, 1.4-13.1), asthma (OR, 2.6; 95% CI, 1.4-4.8), and bronchitis (OR, 1.2; 95% CI, 0.6-2.3).

CONCLUSION

The prevalence of GERD was 3.5% in this Korean population. Heartburn and acid regurgitation were significantly associated with chest pain, dysphagia, globus sensation, hoarseness, and asthma.

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  • Authors+Show Affiliations

    ,

    Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

    , , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Asthma
    Chest Pain
    Cross-Cultural Comparison
    Cross-Sectional Studies
    Deglutition Disorders
    Female
    Gastroesophageal Reflux
    Health Surveys
    Heartburn
    Hoarseness
    Humans
    Incidence
    Korea
    Male
    Middle Aged
    Regression Analysis

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15784014

    Citation

    Cho, Young-Seok, et al. "Prevalence and Clinical Spectrum of Gastroesophageal Reflux: a Population-based Study in Asan-si, Korea." The American Journal of Gastroenterology, vol. 100, no. 4, 2005, pp. 747-53.
    Cho YS, Choi MG, Jeong JJ, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asan-si, Korea. Am J Gastroenterol. 2005;100(4):747-53.
    Cho, Y. S., Choi, M. G., Jeong, J. J., Chung, W. C., Lee, I. S., Kim, S. W., ... Chung, I. S. (2005). Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asan-si, Korea. The American Journal of Gastroenterology, 100(4), pp. 747-53.
    Cho YS, et al. Prevalence and Clinical Spectrum of Gastroesophageal Reflux: a Population-based Study in Asan-si, Korea. Am J Gastroenterol. 2005;100(4):747-53. PubMed PMID: 15784014.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asan-si, Korea. AU - Cho,Young-Seok, AU - Choi,Myung-Gyu, AU - Jeong,Jeong-Jo, AU - Chung,Woo-Chul, AU - Lee,In-Seok, AU - Kim,Sang-Woo, AU - Han,Sok-Won, AU - Choi,Kyu-Yong, AU - Chung,In-Sik, PY - 2005/3/24/pubmed PY - 2005/4/30/medline PY - 2005/3/24/entrez SP - 747 EP - 53 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 100 IS - 4 N2 - BACKGROUND AND AIMS: This study estimated the prevalence and clinical spectrum of gastroesophageal reflux disease (GERD) in Asan-si, Korea, as the prevalence is believed to be lower than in Western countries. METHODS: A cross-sectional survey, using a reliable and valid questionnaire, was performed on randomly selected 2,240 Asan-si residents aged between 18 and 69 yr. All respondents were interviewed at their homes or offices by a team of interviewers. RESULTS: Of the 1,902 eligible subjects, 1,417 (78.4%: male 762; female 655) were surveyed. The prevalence of heartburn occurring at least once a month, at least once a week, and at least twice a week was 4.71% (95% confidence interval (CI), 3.6-5.8), 2.0% (95% CI, 1.2-2.7), and 1.3% (95% CI, 0.7-1.9), respectively. The corresponding figures for acid regurgitation were 4.4% (95% CI, 3.3-5.5) and 2.0% (95% CI, 1.3-2.8), respectively. The prevalence of GERD, defined as heartburn and/or acid regurgitation experienced at least weekly, was 3.5% (95% CI, 2.6-4.5). No significant difference was detected between sexes. The prevalence of heartburn was associated with increasing age (p < 0.001). Nineteen percent of our population reported at least one of the atypical symptoms, for instance, chest pain, dysphagia, globus sensation, asthma, bronchitis, pneumonia, or hoarseness. The frequency of frequent GERD among subjects reporting any of the atypical symptoms was 12.6%, which was higher than that of the subjects without atypical symptoms. Patients with typical reflux symptoms were more common among those with atypical symptoms, compared to those without such symptoms (p < 0.001). Using a logistic regression model after adjusting for age and sex, typical reflux symptoms were associated with chest pain (odds ratio (OR), 9.3; 95% CI, 5.9-14.7), dysphagia (OR, 6.4; 95% CI, 2.8-14.7), globus sensation (OR, 3.9; 95% CI, 1.5-9.7), hoarseness (OR, 4.3; 95% CI, 1.4-13.1), asthma (OR, 2.6; 95% CI, 1.4-4.8), and bronchitis (OR, 1.2; 95% CI, 0.6-2.3). CONCLUSION: The prevalence of GERD was 3.5% in this Korean population. Heartburn and acid regurgitation were significantly associated with chest pain, dysphagia, globus sensation, hoarseness, and asthma. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/15784014/Prevalence_and_clinical_spectrum_of_gastroesophageal_reflux:_a_population_based_study_in_Asan_si_Korea_ L2 - http://Insights.ovid.com/pubmed?pmid=15784014 DB - PRIME DP - Unbound Medicine ER -